Molecular Insights into Bronchiolitis Obliterans
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 15 March 2026
Special Issue Editors
Interests: immunology; pneumology; molecular biology
Interests: pneumology; inflammatory lung disease; bronchiolitis obliterans
Special Issue Information
Dear Colleagues,
We welcome innovative experimental research exploring the molecular mechanisms and pathogenesis of bronchiolitis obliterans (BO), a chronic, irreversible lung disease characterized by severe obstruction and obliteration of the small airways. BO manifests in two entities: either after pulmonary infections (post-infectious BO, PiBO) or following allogeneic hematopoietic stem cell transplantation (bronchiolitis obliterans syndrome, BOS). Although distinct, PiBO and BOS share histopathological features and developmental similarities. The mechanisms driving BO remain largely unclear, and effective therapies are lacking.
This Special Issue aims to improve the understanding of lung tissue injury in BO, emphasizing in vitro and in vivo models that elucidate inflammation, fibrosis, and bronchiolar remodelling. We encourage studies providing insights into novel therapeutic approaches to improve clinical outcomes. Key focus areas include comprehensive molecular analyses such as RNA sequencing and proteomics for detailed transcriptomic and proteomic profiling of patient samples, including induced sputum. Additionally, research on epigenetic regulation, particularly the roles of microRNAs and non-coding RNAs in modulating BO pathogenesis, is of significant interest.
Prof. Dr. Ralf Schubert
Dr. Silvija-Pera Jerkic
Guest Editors
Manuscript Submission Information
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Keywords
- bronchiolitis obliterans (BO)
- inflammation
- fibrosis
- molecular mechanisms
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