Advances in Antiviral Drug Development
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 August 2025 | Viewed by 50
Special Issue Editor
Interests: viral inhibitors; mechanism of action; antiviral tests
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Experimental chemotherapy for applications in viral infections is one of the most rapidly developing research areas in virology. This is largely due to the need for clinically applicable drugs to combat viral pathogens. It is known that viruses play an increasing role in infectious pathology. They are also the predominant agents in nosocomial infections. Three factors contribute to progress in this area: (1) the development of molecular virus biology, elucidating their structure, replication, and variability, as well as the mechanisms of action of viral inhibitors; (2) achievements in protein and nucleic acid chemistry, the synthesis of viral proteins (ligands of antivirals), and anomalous nucleic acids and the development of so-called QSAR analysis to achieve the targeted synthesis of effective antivirals; (3) progress in the development of efficient in vitro methods and in vivo models for the screening and testing of antiviral substances. Key targets in antiviral research include the causative agents of particularly dangerous viral infections (Filoviridae, Togaviridae, Alphaviridae, Bunyaviridae, Rhabdoviridae, etc.), viruses from families with many serotypes (Picornaviridae/Enteroviruses, Rhinoviruses, Caliciviridae, etc.), the causative agents of childhood viral infections and eye infections, and hepatitides. Vaccines have been created for the prevention of a number of widespread viral infections of social importance (such as polio and influenza). Unfortunately, problems with the effectiveness of, for example, the polio vaccine require the creation of effective antivirals against polioviruses. The situation is similar for Paramyxoviridae.
Prof. Dr. Angel S. Galabov
Guest Editor
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Keywords
- viral inhibitors
- mechanism of action
- antiviral tests
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