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Biomolecules
Special Issues
Nanomaterials and Their Applications in Biomedicine
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Nanomaterials and Their Applications in Biomedicine

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bio-Engineered Materials".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 4254

Special Issue Editor

Dr. George Pasparakis

E-Mail Website
Guest Editor
Department of Chemical Engineering, University of Patras, Caratheodory 1, University Campus, Patras, Greece
Interests: photothermal therapy; photodynamic therapy; cancer nanomedicine; polymer-drug conjugates; remotely controlled drug delivery systems; plasmonic nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials constitute a broad class of materials with unique physicochemical properties not found in their corresponding bulk equivalents, which render them ideal components for the construction of therapeutic and diagnostic modalities. For this Special Issue, we invite colleagues to contribute with their manuscripts focusing on nanomaterials—be they polymeric, inorganic, metallic, semiconducting, etc.—for bioapplications in a broad context. Relevant topics include precision medicine, theranostics, photodynamic therapy, antibiotic nanoformulations, biosensing, and applications in tissue regeneration, cell therapeutics, wound healing, and bioinks for additive manufacturing technologies.

Dr. George Pasparakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photothermal and photodynamic therapies and tumor ablation strategies
  • theranostics and image-guided drug delivery
  • biosensors, including surface-enhanced Raman scattering and metal-enhanced fluorescence
  • biosensors
  • point-of-care diagnostics and lateral-flow tests
  • controlled drug delivery, including delivery of RNA/DNA and other biologics
  • additive manufacturing and 3D/4D printing applications
  • antimicrobials
  • cell therapeutics and tissue regeneration

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

20 pages, 4926 KiB  
Article
Tailored Iron Oxide Nanoparticles as Potential Cannabinoid Carriers for Anti-Cancer Treatment
by Jan Taudul, Joanna Celej, Kinga Żelechowska-Matysiak, Daria Kępińska, Agnieszka Majkowska-Pilip, Marcin Strawski, Paweł Krysiński and Dorota Nieciecka
Biomolecules 2025, 15(2), 230; https://doi.org/10.3390/biom15020230 - 5 Feb 2025
Viewed by 558
Abstract
We present a novel, multicomponent nanoparticulate carrier system based on superparamagnetic iron oxide nanoparticles with a designed hydrophilic/hydrophobic balance based on oleic acid and TWEEN 80 to incorporate hydrophobic cannabinoids—cannabigerol and cannabidiol—as well as the hydrophilic anthracycline drug epirubicin, forming a conjugate anticancer [...] Read more.
We present a novel, multicomponent nanoparticulate carrier system based on superparamagnetic iron oxide nanoparticles with a designed hydrophilic/hydrophobic balance based on oleic acid and TWEEN 80 to incorporate hydrophobic cannabinoids—cannabigerol and cannabidiol—as well as the hydrophilic anthracycline drug epirubicin, forming a conjugate anticancer system. Additionally, the superparamagnetic iron oxide-based nanoparticles formed the core of the system, thus providing it with magnetic hyperthermia capabilities with a specific absorption rate comparable to the corresponding systems in the literature. The interaction of the conjugate with the cell membrane was studied using the Langmuir monolayers at the air/water interface formed of selected lipids modeling the healthy and cancerous cell membranes. Finally, cytotoxicity tests were carried out against the SKOV-3 cell line in vitro. A synergistic effect was observed when both the cannabinoid and epirubicin were present in the conjugate, as compared to the cannabinoid or epirubicin alone, making our system advantageous for further development for tentative therapeutic use. Full article
(This article belongs to the Special Issue Nanomaterials and Their Applications in Biomedicine)
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19 pages, 9963 KiB  
Article
Polystyrene–Poly(acrylic acid) Block Copolymers for Encapsulation of Butyrylcholinesterase into Injectable Nanoreactors
by Petr A. Fetin, Ivan M. Zorin, Zukhra M. Shaihutdinova, Patrick Masson and Tatiana N. Pashirova
Biomolecules 2024, 14(12), 1555; https://doi.org/10.3390/biom14121555 - 5 Dec 2024
Viewed by 848
Abstract
The article is devoted to the creation of enzymatic nanoreactors based on polystyrene–block–poly(acrylic acid) (PS-b-PAA) copolymers containing bioscavengers capable of neutralizing toxic esters both in the body and in the environment. Block copolymers of different amphiphilicity, hydrophilicity and molecular weights were synthesized and [...] Read more.
The article is devoted to the creation of enzymatic nanoreactors based on polystyrene–block–poly(acrylic acid) (PS-b-PAA) copolymers containing bioscavengers capable of neutralizing toxic esters both in the body and in the environment. Block copolymers of different amphiphilicity, hydrophilicity and molecular weights were synthesized and characterized using gel permeation chromatography, NMR and UV spectroscopy. Polymeric nanocontainers in the absence and presence of human butyrylcholinesterase were made by film hydration and characterized by dynamic light scattering and microscopy methods. Enzyme activity was determined using the Ellman method. For the first time, factors that need to be taken into account for the creation of effective enzymatic nanoreactors based on PS-b-PAA are presented. The data obtained open up the possibility of PS-b-PAA nanoreactor use for future in vivo bioscavenger studies. Full article
(This article belongs to the Special Issue Nanomaterials and Their Applications in Biomedicine)
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13 pages, 2669 KiB  
Article
Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin
by Hyein Cheung, Haewon Kang, Hyo Jung Lee, Yunjae Chung, Hanbo Shin, Sangmin Lee and Jong-Ho Kim
Biomolecules 2024, 14(10), 1212; https://doi.org/10.3390/biom14101212 - 26 Sep 2024
Viewed by 894
Abstract
Cell membrane-derived liposomes, termed Memposomes, serve as promising carriers for drug delivery due to their ability to closely mimic cells and efficiently target specific cells. Liposomes derived from cancer cell membranes, in particular, exhibit homologous targeting capabilities, making them potential candidates for cancer-specific [...] Read more.
Cell membrane-derived liposomes, termed Memposomes, serve as promising carriers for drug delivery due to their ability to closely mimic cells and efficiently target specific cells. Liposomes derived from cancer cell membranes, in particular, exhibit homologous targeting capabilities, making them potential candidates for cancer-specific drug delivery. However, the underlying mechanisms and specific proteins responsible for this homologous targeting phenomenon remain debated. This study focuses on the role of E-cadherin, a cell adhesion molecule implicated in homophilic adhesion, in influencing the homologous targeting ability of Memposomes derived from cancer cell membranes. E-cadherin expression patterns were assessed in various cell lines, categorizing them into E-cadherin-positive and -negative groups. Memposomes were produced for each group, and their targeting tendencies were evaluated. This study confirmed that E-cadherin expression significantly influenced the homologous targeting ability of the Memposomes. The cell lines with higher E-cadherin expression levels exhibited a more pronounced homologous targeting effect. This research demonstrates that cell adhesion molecules, particularly E-cadherin involved in homophilic adhesion, play a pivotal role in influencing the cell targeting ability of Memposomes. This study further validates the stability, safety, and purity of Memposomes, emphasizing their potential as effective drug delivery vehicles for the development of cell-specific therapies. Full article
(This article belongs to the Special Issue Nanomaterials and Their Applications in Biomedicine)
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11 pages, 1586 KiB  
Article
Nano-Sized Graphene Oxide Attenuates Ovalbumin/Alum-Induced Skin Inflammation by Down-Regulating Th2 Immune Responses in Balb/c Mice
by Hyun Jung Park, Sung Won Lee, Luc Van Kaer, Suklyun Hong and Seokmann Hong
Biomolecules 2024, 14(8), 962; https://doi.org/10.3390/biom14080962 - 7 Aug 2024
Viewed by 1326
Abstract
Graphene oxide (GO), a carbon-based material with oxygen-containing functional groups, can be applied in biomedicine for drug delivery, cancer therapy, and tissue regeneration. We have previously shown that nanoscale-sized graphene oxide (NGO), an oxidized graphene derivative, exhibits effective anti-inflammatory activity in a murine [...] Read more.
Graphene oxide (GO), a carbon-based material with oxygen-containing functional groups, can be applied in biomedicine for drug delivery, cancer therapy, and tissue regeneration. We have previously shown that nanoscale-sized graphene oxide (NGO), an oxidized graphene derivative, exhibits effective anti-inflammatory activity in a murine model of sepsis mediated by T helper (Th)1-promoting cytokines such as IFNγ and TNFα. However, whether NGO influences Th2-induced skin inflammation remains unclear. To address this issue, we employed an ovalbumin (OVA) plus aluminum hydroxide (Alum)-induced Th2-mediated skin inflammation model in conjunction with OVA-specific DO11.10 T cell receptor transgenic Balb/c mice. In vivo NGO injection upon OVA/Alum sensitization down-regulated OVA-elicited antigen-specific Th2 cells and GATA3-expressing Th2-type regulatory T cells. Next, we examined the effect of NGO injection on OVA/Alum-induced atopic dermatitis (AD)-like skin inflammation. NGO-injected mice exhibited significantly decreased Th2 disease phenotypes (e.g., a lower clinical score, decreased epidermal thickness and Th2 cell differentiation, and fewer infiltrated mast cells and basophils in skin lesions) compared with vehicle-injected control mice. Overall, our results suggest that NGOs are promising therapeutic materials for treating allergic diseases such as AD. Full article
(This article belongs to the Special Issue Nanomaterials and Their Applications in Biomedicine)
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