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Biomolecules
Special Issues
Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier
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Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bio-Engineered Materials".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 2743

Special Issue Editors

Dr. Yuping Bao

E-Mail Website
Guest Editor
Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL, USA
Interests: magnetic nanoparticles; imaging-guided drug delivery; MRI
Special Issues, Collections and Topics in MDPI journals
Dr. Jessica M. Larsen

E-Mail Website
Guest Editor
1. Department of Chemical and Biomolecular Engineering, Clemson University, 105 Sikes Hall, Clemson, SC, USA
2. Department of Bioengineering, Clemson University, 105 Sikes Hall, Clemson, SC, USA
Interests: nanomedicine; drug delivery; brain disease; nerve regeneration; biomaterials; polymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Significant advancements in nano-based drug delivery systems have offered promising solutions to various challenges in drug delivery such as improved bioavailability, targeted delivery, and reduced side effects. This Special Issue aims to provide a comprehensive overview of the latest developments in this rapidly evolving field. This Special Issue welcomes key themes and contributions that include, but are not limited to, nanoformulations for targeted/precision therapy, controlled/on-demand smart drug delivery systems, nanoformulations for oral or topical delivery, nanosystems across biological barriers, biomimetic nanocarriers, and challenges and future perspectives. In summary, this Special Issue provides a valuable resource for researchers, clinicians, and industry professionals interested in the latest advances and future prospects of nano-based drug delivery systems. By highlighting cutting-edge research and addressing key challenges, it aims to catalyze further innovation in this rapidly expanding field, ultimately contributing to improved therapeutic outcomes for patients.

Dr. Yuping Bao
Dr. Jessica M. Larsen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • targeted drug delivery
  • smart nanoformulation
  • controlled drug release
  • biocompatible nanocarriers
  • extracellular vesicles
  • immunotherapy

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Published Papers (1 paper)

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Research

15 pages, 2548 KiB  
Article
Extracellular Vesicle-Mediated Modulation of Stem-like Phenotype in Breast Cancer Cells under Fluid Shear Stress
by Spenser R. Brown, Margaret E. Radcliffe, Joseph T. Danner, Wilmer J. Andújar Cruz, Kimberly H. Lackey, Han-A Park, Steven T. Weinman and Yonghyun Kim
Biomolecules 2024, 14(7), 757; https://doi.org/10.3390/biom14070757 - 25 Jun 2024
Cited by 1 | Viewed by 2252
Abstract
Circulating tumor cells (CTCs) are some of the key culprits that cause cancer metastasis and metastasis-related deaths. These cells exist in a dynamic microenvironment where they experience fluid shear stress (FSS), and the CTCs that survive FSS are considered to be highly metastatic [...] Read more.
Circulating tumor cells (CTCs) are some of the key culprits that cause cancer metastasis and metastasis-related deaths. These cells exist in a dynamic microenvironment where they experience fluid shear stress (FSS), and the CTCs that survive FSS are considered to be highly metastatic and stem cell-like. Biophysical stresses such as FSS are also known to cause the production of extracellular vesicles (EVs) that can facilitate cell–cell communication by carrying biomolecular cargos such as microRNAs. Here, we hypothesized that physiological FSS will impact the yield of EV production, and that these EVs will have biomolecules that transform the recipient cells. The EVs were isolated using direct flow filtration with and without FSS from the MDA-MB-231 cancer cell line, and the expression of key stemness-related genes and microRNAs was characterized. There was a significantly increased yield of EVs under FSS. These EVs also contained significantly increased levels of miR-21, which was previously implicated to promote metastatic progression and chemotherapeutic resistance. When these EVs from FSS were introduced to MCF-7 cancer cells, the recipient cells had a significant increase in their stem-like gene expression and CD44+/CD24− cancer stem cell-like subpopulation. There was also a correlated increased proliferation along with an increased ATP production. Together, these findings indicate that the presence of physiological FSS can directly influence the EVs’ production and their contents, and that the EV-mediated transfer of miR-21 can have an important role in FSS-existing contexts, such as in cancer metastasis. Full article
(This article belongs to the Special Issue Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier)
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