Bioactive Compounds as Modifiers of Mitochondrial Function

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-derived Molecules".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 2235

Special Issue Editor


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Guest Editor
Department of Physiology & Pharmacology, Sam Houston State University College of Osteopathic Medicine, 925 City Central Ave., Conroe, TX 77304, USA
Interests: cellular bioenergetics; redox biology; oxidative stress; thermobiology; muscle physiology; cancer pathophysiology; metabolic syndrome; neurodegenerative diseases

Special Issue Information

Dear Colleagues,

Mitochondria is an organelle found in most eukaryotic cells, with a primary function of generating energy in the form of adenosine triphosphate (ATP). In addition to producing energy, mitochondria functions include storing calcium for cell signaling activities, generating heat when needed, and mediating cell growth and death. Bioactive compounds (broadly defined as natural, artificial, or synthesized compounds) could exhibit actions in the human body that may promote or improve health. Bioactive compounds have been studied and used since ancient times for their potential role in reducing illnesses, infections, cancer, diabetes, heart failure, Alzheimer and other diseases. In this Special Issue, we invite you to submit your original manuscripts, reviews, and special communications focusing on mitochondrial aspects of bioactive compound effects in the context of human or animal pathophysiology, pharmacology, and general health.

Dr. Mihail "Mike" Mitov
Guest Editor

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Keywords

  • natural bioactive compounds
  • synthesized bioactive compounds
  • mitochondrial function
  • electron transport chain (ETC)
  • ATP production rate
  • oxygen consumption rate (OCR)
  • extracellular acidification rate (ECAR)

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Published Papers (1 paper)

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Review

29 pages, 2132 KB  
Review
Polyphenol-Based Therapeutic Strategies for Mitochondrial Dysfunction in Aging
by Tamara Maksimović, Carmen Gădău, Gabriela Antal, Mihaela Čoban, Oana Eșanu, Elisabeta Atyim, Alexandra Mioc and Codruța Șoica
Biomolecules 2025, 15(8), 1116; https://doi.org/10.3390/biom15081116 - 3 Aug 2025
Viewed by 1343
Abstract
Aging, a progressive and time-dependent decline in physiological functions, is driven by interconnected hallmarks, among which mitochondrial dysfunction plays a central role. Mitochondria not only regulate energy production but also play key roles in other cellular processes, including ROS generation, apoptosis, and metabolic [...] Read more.
Aging, a progressive and time-dependent decline in physiological functions, is driven by interconnected hallmarks, among which mitochondrial dysfunction plays a central role. Mitochondria not only regulate energy production but also play key roles in other cellular processes, including ROS generation, apoptosis, and metabolic signaling—all of which decline with aging. Polyphenols are a diverse group of natural compounds found in fruits, vegetables, tea, and wine; they emerged as promising anti-aging agents due to their ability to modulate several hallmarks of aging, particularly mitochondrial dysfunction. This review explores how various polyphenolic classes influence mitochondrial function and mitigate aging-related decline. These natural compounds have been shown to reduce oxidative stress, increase energy production, and help maintain normal mitochondrial structure. Moreover, in vitro and in vivo studies suggest that polyphenols can delay signs of aging and improve physical and cognitive functions. Overall, polyphenols show great potential to promote healthy aging and even delay the decline in physiological functions by protecting and enhancing mitochondrial health. Full article
(This article belongs to the Special Issue Bioactive Compounds as Modifiers of Mitochondrial Function)
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