Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.4
4.8
Journals
Biomolecules
Special Issues
Molecular Mechanisms and Pathophysiology of Gliomas
share announcement

Molecular Mechanisms and Pathophysiology of Gliomas

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 364

Special Issue Editor

Dr. Fengchao Lang

E-Mail Website
Guest Editor
Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Interests: glioma; targeted therapies; DNA repair; replication stress
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gliomas are the most common cancers of the central nervous system. According to the WHO 2021 classification, gliomas are primarily categorized based on genetic alterations into astrocytomas (IDH-mutant), oligodendrogliomas (IDH-mutant, 1p/19q co-deleted), and glioblastomas (IDH-wildtype). These tumors exhibit a range of genetic and epigenetic changes that drive their progression. Common mutations include IDH1/2, TP53, and ATRX, alongside alterations in critical pathways such as RTK/PI3K, RAS/MAPK, and cell-cycle regulation. Epigenetic modifications, such as DNA hypermethylation and histone methylation in IDH-mutant gliomas, also influence tumor behavior and therapeutic responses.

Gliomas leverage metabolic reprogramming, including the Warburg effect and the production of 2-hydroxyglutarate (D-2-HG) in IDH-mutant tumors, to promote growth and survival. Additionally, the tumor microenvironment plays a pivotal role in glioma pathophysiology, with complex interactions among tumor cells, immune cells, and vascular structures driving immune evasion, angiogenesis, and tumor progression.

A deeper understanding of these molecular and pathophysiological mechanisms is crucial for the development of targeted therapies and improvement in patient outcomes.

Dr. Fengchao Lang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gliomas
  • cell cycle
  • epigenetic modifications
  • metabolic reprogramming
  • tumor microenvironment
  • targeted therapies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

31 pages, 2890 KiB  
Review
Liquid Biopsy-Derived Tumor Biomarkers for Clinical Applications in Glioblastoma
by Bruna Pereira de Lima, Leticia Silva Ferraz, Sylvie Devalle and Helena Lobo Borges
Biomolecules 2025, 15(5), 658; https://doi.org/10.3390/biom15050658 - 2 May 2025
Viewed by 179
Abstract
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid growth and resistance to chemotherapy. Conventional treatments remain largely ineffective, with patient survival averaging around 18 months after diagnosis. Current diagnostic methods rely on invasive tissue biopsies and imaging [...] Read more.
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid growth and resistance to chemotherapy. Conventional treatments remain largely ineffective, with patient survival averaging around 18 months after diagnosis. Current diagnostic methods rely on invasive tissue biopsies and imaging tests. While traditional biopsies involve extracting tissue samples, their routine use is often limited by surgical risks and the challenge of accessing sensitive brain regions. Liquid biopsy has emerged as a promising noninvasive alternative, analyzing circulating tumor components—such as DNA, RNA, extracellular vesicles, and microRNAs—found in body fluids. This approach enables initial diagnosis and continuous disease monitoring, offering a significant advantage over traditional biopsies, which are impractical for frequent repetition during treatment follow-up. This review highlights recent advances in liquid biopsy-derived biomarkers for the clinical management of GBM. The discussion includes the advantages, limitations, and potential of these biomarkers as tools for early diagnosis and disease monitoring. A narrative review of the literature published over the last decade (2014–2024) was conducted using major health-focused scientific databases. The analysis focuses on evaluating the clinical relevance and applicability of liquid biopsy in GBM, offering insights into its potential as a minimally invasive and effective tool for improving glioblastoma management. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Pathophysiology of Gliomas)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop