Roles of Alpha-1 Antitrypsin in Human Health and Disease Models
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 15 September 2025 | Viewed by 1615
Special Issue Editor
Interests: functions and applications of alpha-1 antitrypsin (AAT) and SERPIN; development of novel treatment for autoimmune and inflammatory diseases; gene therapy using recombinant adeno-associated viral vectors (rAAV)
Special Issue Information
Dear Colleagues,
Alpha-1 antitrypsin (AAT), a member of serine proteinase inhibitor (SERPIN) superfamily, has multiple functions including the inhibition of proteinases and the regulation of immune system. As a proteinase inhibitor, AAT can reduce tissue damage and degeneration, which is commonly involved in autoimmune and inflammatory diseases. AAT can also interact with immune regulatory molecules and mediate anti-inflammatory effects. Studies have shown that AAT has the therapeutic potential for the treatment of human diseases including AAT deficiency (AATD), graft-versus-host disease (GvHD), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and COVID-19. However, the mechanism(s) underlying the therapeutic effects of AAT remain elusive. In addition, AAT may have unknown functions to be further investigated. This Specific Issue aims to publish recent findings that advance the therapeutic applications and the functional mechanism(s) of AAT and related molecules.
Prof. Dr. Sihong Song
Guest Editor
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Keywords
- alpha-1 antitrypsin
- serine proteinase inhibitor (SERPIN)
- autoimmunity
- inflammation
- aging
- cancer
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