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Biomolecules
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Advances in Plasma Bioscience and Medicine: 2nd Edition
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Advances in Plasma Bioscience and Medicine: 2nd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biophysics: Structure, Dynamics, and Function".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 795

Special Issue Editors

Dr. Yuantao Zhang

E-Mail Website
Guest Editor
School of Electrical Engineering, Shandong University, Jinan 250061, China
Interests: plasma medicine; plasma–biomolecule interactions; computer simulations; molecular dynamics
Dr. Maksudbek Yusupov

E-Mail Website
Guest Editor
1. Institute of Fundamental and Applied Research, National Research University TIIAME, Tashkent 100000, Uzbekistan
2. Research Group PLASMANT, Department of Chemistry, University of Antwerp, 2610 Antwerp, Belgium
Interests: plasma medicine; plasma–biomolecule interactions; computer simulations; molecular dynamics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of a Special Issue on “Advances in Plasma Bioscience and Medicine”.

Plasma medicine, i.e., the biomedical application of non-thermal atmospheric pressure plasma (NTP), is gaining increasing interest, with applications in the sterilization of microorganisms (i.e., bacteria, fungi and viruses), food decontamination, wound healing and even cancer treatment.

It is widely accepted that the biological and medical effects of NTP are related to reactive oxygen and nitrogen species (RONSs). While high doses of NTP-generated RONSs are undeniably "harmful" to any cell/organism, the delivery of low doses of specific RONSs may be beneficial in the aforementioned therapies.

The argument follows that RONSs regulate key biochemical pathways within intra- and intercellular environments, inducing chemical and physical modifications in cellular components, oxidizing or breaking them into fragments. Studies have already shown that the treatment of living cells with NTP induces changes in intracellular signaling, which is important in the treatment of diseases. However, it is still unclear how plasma-generated RONSs regulate intracellular processes. If these processes are better understood, it will allow us to develop more targeted and effective medical plasma therapy.

In this Special Issue of Biomolecules, we aim to offer a platform for high-quality publications focused on the fundamental understanding of the impact of NTP-generated RONSs on biomolecules, or the implications of these interactions in the context of plasma medicine.

Research areas may include (but are not limited to) the following:

  • Plasma medicine;
  • Plasma oncology;
  • Plasma disinfection;
  • Plasma wound healing;
  • Plasma immunotherapy;
  • Plasma-activated liquid.

We look forward to receiving your contributions.

Dr. Yuantao Zhang
Dr. Maksudbek Yusupov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-thermal (cold) atmospheric pressure plasma
  • reactive oxygen and nitrogen species (RONSs)
  • plasma–biomolecule interactions
  • plasma cancer treatment
  • plasma immunomodulation
  • plasma inactivation of viruses, fungi and bacteria
  • plasma–liquid interactions
  • computer simulations

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Related Special Issue

Published Papers (2 papers)

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16 pages, 1930 KiB  
Article
A Microfluidic System for Real-Time Monitoring and In Situ Metabolite Detection of Plasma-Enhanced Wound Healing
by Zujie Gao, Jinlong Xu, Hengxin Zhao, Xiaobing Zheng, Zijian Lyu, Qiwei Liu, Hao Chen, Yu Zhang, He-Ping Li and Yongjian Li
Biomolecules 2025, 15(8), 1077; https://doi.org/10.3390/biom15081077 - 25 Jul 2025
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Abstract
Although cold atmospheric plasma (CAP) has shown promise in facilitating wound repair due to its non-thermal and non-invasive properties, its dynamic effects on cellular response and metabolic regulation remain poorly characterized, and the mechanism is still unclear. In this study, we developed a [...] Read more.
Although cold atmospheric plasma (CAP) has shown promise in facilitating wound repair due to its non-thermal and non-invasive properties, its dynamic effects on cellular response and metabolic regulation remain poorly characterized, and the mechanism is still unclear. In this study, we developed a microfluidic experimental system that integrates a CAP treatment module with multiparametric in situ sensing capabilities, along with precise environmental control of temperature, humidity, and CO2 concentration. A stratified microfluidic chip was engineered to co-culture HaCaT keratinocytes and HSF fibroblasts. CAP treatment was applied within this platform, and the dynamic processes of cell migration, proliferation, and multiple metabolic markers were simultaneously monitored. The experimental results show that the system can not only achieve real-time observation in the healing process under plasma intervention, but also find that the healing process is closely related to the concentration of NO2−. In addition, the study also found that keratin KRT14, which is thought to be closely related to wound healing, decreased significantly in the process of plasma-induced healing. The platform provides high-resolution experimental tools to elucidate the biological effects of CAP and has the potential for parameter optimization, material evaluation, and personalized therapeutic development to advance plasma research and clinical translational applications. Full article
(This article belongs to the Special Issue Advances in Plasma Bioscience and Medicine: 2nd Edition)
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19 pages, 15652 KiB  
Article
Molecular Dynamics Simulations of Plasma–Antifolate Drug Synergy in Cancer Therapy
by Yanxiong Niu, Tong Zhao, Xiaolong Wang, Ying Sun and Yuantao Zhang
Biomolecules 2025, 15(6), 773; https://doi.org/10.3390/biom15060773 - 27 May 2025
Viewed by 485
Abstract
Reactive oxygen species (ROS) generated by cold atmospheric plasma (CAP) cause irreversible damage to cancer cell DNA, RNA, mitochondria, and antioxidant defense systems, leading to apoptosis. Plasma-induced disruption of the antioxidant defense system of cancer cells by cystine uptake via xC− antiporter [...] Read more.
Reactive oxygen species (ROS) generated by cold atmospheric plasma (CAP) cause irreversible damage to cancer cell DNA, RNA, mitochondria, and antioxidant defense systems, leading to apoptosis. Plasma-induced disruption of the antioxidant defense system of cancer cells by cystine uptake via xC− antiporter has been widely studied, while folate uptake by cancer cells via high expression of hSLC19A1, which generates Nicotinamide Adenine Dinucleotide Phosphate (NADPH) via one-carbon metabolism, is also an important component of the antioxidant defense mechanism of cancer cells. Disrupting folate transport in cancer cells is an important potential pathway for synergizing with pemetrexed (PMX) to induce apoptosis in cancer cells, which is of great research value. In this paper, classical molecular dynamics simulations were employed to study the effect of plasma oxidation of hSLC19A1 on the uptake of 5-Methyltetrahydrofolate (5-MTHF), which is the predominant dietary and circulatory folate, and the antifolate chemotherapeutic agent PMX by cancer cells. The results showed that the channel radius of hSLC19A1 for transporting 5MTHF after oxidation became narrower and the conformation tended to be closed, which was unfavorable for the transport of 5-MTHF; hydrogen bonding and hydrophobic interactions between hSLC19A1 and 5-MTHF decreased, the predicted docking affinity decreased, and the binding energy decreased from −28.023 kcal/mol to −16.866 kcal/mol, while that with PMX was stable around −28 kcal/mol, suggesting that the oxidative modification reduced the binding capacity of hSLC19A1 and 5-MTHF while barely affecting the transport of PMX, which contributed to weakening the antioxidant defense system of cancer cells and synergizing with PMX to induce apoptosis in cancer cells. Our simulations provide theoretical insights for CAP-induced apoptosis in cancer cells at the microscopic level and help promote the further development of cold atmospheric plasma in the field of cancer therapy. Full article
(This article belongs to the Special Issue Advances in Plasma Bioscience and Medicine: 2nd Edition)
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