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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Biological Research on Prostate Cancer

edited by Samson Mashele and Pakiso Makhoahle

submission deadline 31 May 2026 | 1 articles | Viewed by 734 | Submission Open

Keywords: prostate cancer; biological research; molecular mechanisms; biomarkers; precision medicine; therapeutic targets; tumor microenvironment; therapeutic resistance; genomics; quality of life

(This special issue belongs to the Section Cancer Biology)

Understanding and Targeting Biological Mechanisms of Heart Failure (2nd Edition)

edited by

Lei Ye

and

Wuqiang Zhu

submission deadline 31 May 2026 | Viewed by 617 | Submission Open

Keywords: developmental biology; genetics; stem cells; heart failure; cell therapy

(This special issue belongs to the Section Biochemistry and Molecular Biology)

New Insights in Cancer Genetics—2nd Edition

edited by

Ilda Patrícia Ribeiro

, Isabel Marques Carreira and

Alberto Orfao

submission deadline 31 May 2026 | 1 articles | Viewed by 427 | Submission Open

Keywords: genomic and epigenetic characterization; diagnosis and prognosis biomarkers; omics profiles; genetic and genomic signature; molecular heterogeneity; molecular targeted therapy; oncogenic signaling pathways; copy number alterations and mutational landscape; chromosome abnormalities

(This special issue belongs to the Section Cancer Biology)

Understanding Syncope: Multidisciplinary Approaches to Diagnosis and Management

edited by

Isabel Rocha

and Laranjo Sergio

submission deadline 31 May 2026 | Viewed by 287 | Submission Open

Keywords: syncope; diagnostic strategies; prognostication; treatment options; quality of life; wearable devices; artificial intelligence; autonomic dysfunction; orthostatic hypotension; POTS (postural orthostatic tachycardia syndrome)

(This special issue belongs to the Section Neuroscience)

Studies on Antioxidant Activity of Natural Products from Plants

edited by

Pornsiri Pitchakarn

and

Piya Temviriyanukul

submission deadline 31 May 2026 | Viewed by 262 | Submission Open

Keywords: plant natural products; phytochemicals; antioxidant activity; free radical scavenging; functional foods; oxidative stress-accelerated diseases

(This special issue belongs to the Section Plant Science)

Pluripotent Stem Cells in Development and Disease

edited by

Qiang Wu

submission deadline 31 May 2026 | Viewed by 111 | Submission Open

Keywords: pluripotent stem cells (PSCs); early development; regenerative medicine; genetic/epigenetic factors; differentiation; cell fate determination; disease modelling; organoids; genomic editing; single-cell omics

(This special issue belongs to the Section Developmental and Reproductive Biology)

Machine Learning Advanced Research on Ecosystem Carbon and Nitrogen Cycles

edited by Fenghui Yuan and

Tao Liu

submission deadline 31 May 2026 | Viewed by 89 | Submission Open

Keywords: machine learning; biogeochemical cycles; ecosystem modeling; carbon cycling; nitrogen cycling; greenhouse gas; climate change; land-use change; data assimilation

(This special issue belongs to the Section Ecology)

Head and Neck Cancer: Current Advances and Future Perspectives

edited by Ana Jotic

submission deadline 31 May 2026 | Viewed by 64 | Submission Open

Keywords: head and neck cancer; tumor microenvironment; genetic and epigenetic alterations; oncogenes and tumor suppressor genes; signal transduction pathways; immune evasion; metastasis; drug resistance mechanisms; molecular etiology; cancer biology

(This special issue belongs to the Section Cancer Biology)

Coping with Temperature Increase Induced by Climate Warming: Trends in Ectothermic Species—2nd Edition

edited by

Andreas Walzer

submission deadline 31 May 2026 | Viewed by 62 | Submission Open

Keywords: biodiversity; climate warming; ectothermic species; geographic ranges; heat waves; evolutionary adaptations; phenotypic plasticity; species interactions; thermal acclimation

Studies on Insect Genetics and Genomics

edited by Ying Lin

submission deadline 31 May 2026 | Viewed by 55 | Submission Open

Keywords: novel sequencing technologies; genome-editing methods; sex chromosome origins; horizontal gene transfer; resource insects; eco-friendly insect control technologies; genomics; ecology; molecular biology; insect

(This special issue belongs to the Section Genetics and Genomics)

Animal Models for Immune and Infectious Diseases

edited by Shijun Zheng

submission deadline 31 May 2026 | Viewed by 38 | Submission Open

Keywords: animal models; immune responses; autoimmunity; infectious diseases; host– pathogen interaction; immunotherapies

Wetland Ecosystems (2nd Edition)

edited by

Jian Li

, Chenglang Pan and Qiang Wang

submission deadline 1 Jun 2026 | 12 articles | Viewed by 22641 | Submission Open

Keywords: biological invasion; pollution; carbon sink function; the biogeochemical cycle of biogenic elements; population and community ecology; global climate change; coastal zone management; the structure and function of the microbiome; environmental adaptation mechanisms of wetland organisms; wetland landscape; wetland degradation

(This special issue belongs to the Section Ecology)

Animal Models of Neurodegenerative Diseases

edited by Xiangyu Guo

submission deadline 1 Jun 2026 | 6 articles | Viewed by 11391 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer's disease; amyotrophic lateral sclerosis; Parkinson's disease; Huntington's disease; neuroscience; animal models; pathogenesis

(This special issue belongs to the Section Neuroscience)

Biomarkers in Stress Biology and Ecology

edited by

and

submission deadline 1 Jun 2026 | 3 articles | Viewed by 8368 | Submission Open

Keywords: biomarkers; ecotoxicology; environmental contamination; stress ecology; neurotoxicity; oxidative stress; pollution

Interactions and Cross-Kingdom Regulation of Hosts and Pathogens/Parasites

edited by

Rui Guo

and Jianfeng Qiu

submission deadline 1 Jun 2026 | Viewed by 84 | Submission Open

Keywords: host; pathogen; parasite; interaction; cross-kingdom regulation; immune response; infection

(This special issue belongs to the Section Microbiology)

Recent Advances in Biosynthesis and Degradation of Plant Anthocyanin

edited by

Qinsong Yang

and

Minjie Qian

submission deadline 15 Jun 2026 | 6 articles | Viewed by 14308 | Submission Open

Keywords: anthocyanin; fruit ripening; flowering coloration; leaf coloration; secondary metabolite; molecular mechanism

(This special issue belongs to the Section Plant Science)

From Basics to Applications of Gene Regulatory Networks

edited by

Thomas Ulas

submission deadline 15 Jun 2026 | 3 articles | Viewed by 5211 | Submission Open

Keywords: gene regulatory networks; computational methods; modeling and simulation; disease mechanisms; therapeutic targeting; transcriptomics

(This special issue belongs to the Section Genetics and Genomics)

Pregnancy Health and Complications: Molecular Processes and Mechanisms

edited by

Shibin Cheng

submission deadline 30 Jun 2026 | 6 articles | Viewed by 27948 | Submission Open

Keywords: placenta; uterine; fetus; adverse pregnancy outcome; preterm birth; preeclampsia; gestational diabetes; maternal– fetal interface; immune tolerance; inflammation

(This special issue belongs to the Section Developmental and Reproductive Biology)

New Insights into Skeletal Muscle Metabolism in Pathological and Physiological Conditions

edited by

Cristina Antinozzi

submission deadline 30 Jun 2026 | 8 articles | Viewed by 7119 | Submission Open

Keywords: skeletal muscle; muscle diseases; hormones; physical exercise; muscle physiology; biomarkers; disease prevention; antibodies; pharmacological approaches; cell metabolism

(This special issue belongs to the Section Cell Biology)

Advances in Infection and Genetic Diversity of Zoonotic Parasites, Hosts and Vectors

edited by

Weerachai Saijuntha

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1297 | Submission Open

Keywords: zoonotic parasites; prevalence of infection; helminths; protozoa; vectors; genetic diversity; zoonoses; hosts

(This special issue belongs to the Section Infection Biology)

Plant Stress Physiology: A Trait Perspective

edited by Shuang-Xi Zhou,

Aoxue Wang

and Yanchang Wang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1001 | Submission Open

Keywords: photosynthetic traits; hydraulic traits; metabolic traits; stoichiometric traits; molecular traits; trait plasticity; trait adjustment; stress adaptation; climate resilience

(This special issue belongs to the Section Plant Science)

Metals in Biology (2nd Edition)

edited by

Muhamed Amin

submission deadline 30 Jun 2026 | Viewed by 959 | Submission Open

Keywords: metalloenzymes; iron sulfur cluster; mn cluster; photosystem I; photosystem II

Latest Research in Cancer Multi-Omics

edited by Philip Anthony Sutera

submission deadline 30 Jun 2026 | 1 articles | Viewed by 953 | Submission Open

Keywords: cancer; multi-omics; genomics; transcriptomics; proteomics; metabolomics; radiomics; pathomics; precision medicine; artificial intelligence

(This special issue belongs to the Section Bioinformatics)

Current Advances in Echinoderm Research (2nd Edition)

edited by

Muyan Chen

and

Xiutang Yuan

submission deadline 30 Jun 2026 | 1 articles | Viewed by 403 | Submission Open

Keywords: echinoderms; sea cucumbers; starfish; brittle stars; sea urchins

Interactions Between Membrane Proteins and Membrane Lipids

edited by

Youzhong Guo

submission deadline 30 Jun 2026 | Viewed by 387 | Submission Open

Keywords: membrane protein; lipid bilayer; enzyme; channel; receptor; transporter; cryo-EM; X-ray crystallography; structural biology; drug target

(This special issue belongs to the Section Biophysics)

Paper Collection: Understanding Immune Systems

edited by

Sigrun Lange

and Jameel M. Inal

submission deadline 30 Jun 2026 | Viewed by 354 | Submission Open

Keywords: immune mechanisms; evolutionary immunology; comparative immunology; innate immunity; adaptive immunity; autoimmunity; chronic inflammation; immune ageing; host– pathogen interactions; vaccinology; regenerative medicine

(This special issue belongs to the Section Immunology)

Evolution, Genetics, and Conservation of Wildlife Respond to Environmental Changes

edited by Jiang Chang and

Shuping Wang

submission deadline 30 Jun 2026 | Viewed by 155 | Submission Open

Keywords: environmental change; wildlife; rapid evolution; genetic diversity; conservation genomics; environmental DNA; species distribution models; adaptive evolution; eco-evolutionary dynamics

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Advances in Research on Diseases of Plants (2nd Edition)

edited by

Wei Cheng

submission deadline 30 Jun 2026 | Viewed by 140 | Submission Open

Keywords: phytopathogen; plant immunity; plant disease resistance; gene expression/regulation; signal regulation; pathogenesis; virulence; genetic engineering; disease control

(This special issue belongs to the Section Plant Science)

Advances in Biological Breast Cancer Research (2nd Edition)

edited by Anna-Mart Engelbrecht,

Joji Mercier

and

Iman Van Den Bout

submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open

Keywords: breast cancer; breast tumor; breast cancer cells; animal models; cell death; cancer diagnosis; cancer treatment; biomarkers; cancer microenvironment; carcinogens; estrogen receptor; molecular biology; cell biology

(This special issue belongs to the Section Cancer Biology)

Precision Nutrition: Unraveling the Molecular Physiology of Nutrient–Gut–Health Axis in Livestock and Poultry

edited by Shengchen Wang, Tingting Li and Xiaoyan Cui

submission deadline 30 Jun 2026 | Viewed by 69 | Submission Open

Keywords: livestock; poultry; animal production; essential nutrients; bioactive compounds; metabolism; animal health; gut physiology; microbiota; molecular

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Genomics and Bioinformatics in Microorganism from the Class Insecta

edited by Irám Pablo Rodríguez-Sánchez

submission deadline 30 Jun 2026 | Viewed by 68 | Submission Open

Keywords: genomics; bioinformatics; microbial communities; insect microbiomes; multi-omics; metagenomics; transcriptomics; host-microbe interactions; evolutionary dynamicsbiotechnological applications

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Genetic Breeding and Reproduction of Aquatic Animals—2nd Edition

edited by

Huaping Zhu

, Dongmei Ma and

Zaixuan Zhong

submission deadline 30 Jun 2026 | Viewed by 65 | Submission Open

Keywords: genetic breeding; reproduction technology; gene; protein; molecular marker; trait; QTLs; molecular marker; fish; shrimp; crab; shellfish; aquatic animals; transcriptomics; proteomics; metabonomics

(This special issue belongs to the Section Zoology)

Research Advances in Aquatic Omics

edited by

Zhengyong Wen

Qiong Shi

and Haiping Liu

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: aquatic animals; genomics; transcriptomics; proteomics; metabolomics; genetics; evolutionary biology

(This special issue belongs to the Section Evolutionary Biology)

Biology, Ecology and Management of Invasive Alien Plants (2nd Edition)

edited by

Guoqi Chen

and

Jiang Wang

submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open

Keywords: changes in the composition and distribution of alien plants; invasive mechanisms; invasiveness; invasibility; invasive population; invasive plant interactions with other organisms; impacts on environment; ecosystem services and human health; chemical control; management of invasive plants; utilization of invasive plants

(This special issue belongs to the Section Plant Science)

Cytochrome P450s Across Biological Systems: From Molecular Mechanisms to Biotechnological and Biomedical Applications

edited by

Pradeepraj Durairaj

submission deadline 30 Jun 2026 | Viewed by 46 | Submission Open

Keywords: cytochrome P450 (CYP450); drug metabolism; xenobiotic metabolism; biocatalysis and biotransformation; orphan enzymes; redox biology; structural biology; synthetic biology; enzyme engineering; multi-omics approaches

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Breaking Barriers in Metabolic Health: Novel Insights into Obesity and Metabolic Disorders

edited by Aijun Qiao

submission deadline 30 Jun 2026 | Viewed by 46 | Submission Open

Keywords: metabolic disorders; pathogenesis and mechanisms; biomarkers

(This special issue belongs to the Section Medical Biology)

The Plasticity of Autonomic Ganglia

edited by

Miguel Angel Morales

submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open

Keywords: acetylcholine; GABA; co-transmission; neuroplasticity; transmitter segregation; synapse; gLTP; binge-eating disorders; dysautonomia; heart disease

(This special issue belongs to the Section Neuroscience)

Yeasts Biotechnological Applications

edited by

Pornthap Thanonkeo

submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open

Keywords: biofuel and feed production; biological control; waste treatment and utilization; yeast metabolites; enzyme technology; yeast strain development; process development

(This special issue belongs to the Section Biotechnology)

Nutritional Physiology of Animals

edited by

Bai Xue

Yuhong Gao

and Jia Zhou

submission deadline 30 Jun 2026 | Viewed by 32 | Submission Open

Keywords: animals; nutrition; feed additives; novel feed resources; physiology; digestibility; metabolism; stress; reproduction; multi-omics

(This special issue belongs to the Section Physiology)

Biosynthesis and Regulation of Plant Tissue-Specific Metabolites

edited by

Xiumin Fu

submission deadline 30 Jun 2026 | Viewed by 21 | Submission Open

Keywords: underground tissue metabolites; root; root exudates; genetic regulation; rhizosphere microbial interaction; environmental response

(This special issue belongs to the Section Plant Science)

Immune Response Regulation in Animals (2nd Edition)

edited by

Rong Gao

and

Hua-Ji Qiu

submission deadline 30 Jun 2026 | Viewed by 14 | Submission Open

Keywords: immunoregulation of animals; vaccination; immunomodulators; immune memory; cytokine; biotechnology; immune response; molecular networks

(This special issue belongs to the Section Immunology)

Research on the Interaction Mechanism Between Animal Intestine and Its Microbiota

edited by

Zongjie Li

and Xiaomin Guo

submission deadline 1 Jul 2026 | Viewed by 183 | Submission Open

Keywords: animal disease; innate immunity; gut microbiota; gut barrier; immune homeostasis

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Feature Papers in 'Conservation Biology and Biodiversity' (2nd Edition)

edited by

Ettore Randi

submission deadline 1 Jul 2026 | Viewed by 19 | Submission Open

Keywords: population genomics and diversity; heterozygosity; inbreeding; hybridization; adaptive introgression; natural selection; speciation; bottleneck and population fragmentation; genetic drift; gene flow; extinction risk; evolvability; paleogenomics; phylogeography; conservation units; ecotypes; phylogenetics and systematics; eDNA; non-invasive genetic sampling; environmental monitoring

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Microbial Responses, Pollutant Toxicity Mechanisms, and Human Health Implications

edited by

Chao Song

, Zhongquan Jiang and

Jiale Chen

submission deadline 10 Jul 2026 | Viewed by 123 | Submission Open

Keywords: heavy metal and emerging pollutants; microbiology and plant physiology; aquatic biology; environmental chemistry; anthropogenic disturbances; machine learning; pangenome analysis; computational toxicology; human health

Reproductive Physiology and Pathology in Livestock

edited by Claudio Gustavo Ustavo Barbeito and

Fabiano José Ferreira De Sant’Ana

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5102 | Submission Open

Keywords: livestock; animal reproduction; reproductive biology; physiology and pathology of reproduction; experimental models; non-conventional species; biotechnology; immunology

(This special issue belongs to the Section Developmental and Reproductive Biology)

Ecological Regulation of Forest and Grassland Pests

edited by

Dun Wang

and Liangjian Qu

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4639 | Submission Open

Keywords: forest and grassland pests; ecological regulation; sustainable IPM; biological control; forest management

(This special issue belongs to the Section Ecology)

Animal Models of Metabolic Diseases

edited by

Júlio Cezar De Oliveira

and

Melvin Khee Shing Leow

submission deadline 31 Jul 2026 | 5 articles | Viewed by 4316 | Submission Open

Keywords: experimental models; metabolic syndrome; insulin resistance; type 2 diabetes mellitus; obesity; dyslipidemia; hypertension; metabolic programming; DOHaD

(This special issue belongs to the Section Physiology)

The Future of Marine Megafauna

edited by

Vincent L. Bels

and

John R. Turner

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2242 | Submission Open

Keywords: marine biodiversity; marine megafauna; anthropogenic impacts; conservation biology; marine ecosystems; behavioural ecology; marine protected areas (MPAs); ecological resilience; evolutionary biology; species recovery strategies

(This special issue belongs to the Section Zoology)

Advances in Microbial Enzyme Engineering

edited by

Thanongsak Chaiyaso

and Kamon Yakul

submission deadline 31 Jul 2026 | Viewed by 440 | Submission Open

Keywords: microbial enzyme engineering; lignocellulolytic enzymes; biorefinery applications; protein engineering; enzyme-based biomass conversion; synthetic biology

(This special issue belongs to the Section Microbiology)

Environmental and Nutritional Stress: Metabolic Consequences and Regulatory Strategies in Animals

edited by

Wenqiang Ma

submission deadline 31 Jul 2026 | Viewed by 49 | Submission Open

Keywords: stress physiology; metabolic dysfunction; environmental stress; nutritional stress; gut microbiota; bioactive compounds

(This special issue belongs to the Section Physiology)

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