The Molecular and Cellular Mechanisms of Lung Injury and Recovery
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 33
Special Issue Editors
Interests: acute lung injury; chronic lung injury; ARDS; fibrosis; allergy; mechanisms; therapy; infection; inflammation; endothelial barrier
Interests: acute lung injury; chronic lung injury; ARDS; fibrosis; allergy; mechanisms; therapy; infection; inflammation; endothelial barrier
Special Issue Information
Dear Colleagues,
Lung injury, caused by a variety of factors, remains a leading cause of death worldwide, yet its underlying mechanisms are still poorly understood. During the onset of acute lung injury, significant alterations occur in alveolar structure, including disruption of the endothelial–epithelial barrier and infiltration of inflammatory cells and protein-rich fluid into the alveolar spaces. These pathological changes compromise the lung’s capacity for oxygen–carbon dioxide exchange and can progress to acute respiratory distress syndrome (ARDS). In the recovery phase, injured lung cells may undergo apoptosis or regeneration, processes regulated by multiple molecular pathways.
In contrast to acute lung injury, chronic challenges—such as immune dysregulation, hypoxia, or chemical exposures—can lead to lung fibrosis, pulmonary emphysema, or pulmonary hypertension.
A better understanding of the molecular and cellular mechanisms driving these processes will aid in improving outcomes for patients with both acute and chronic lung injuries.
We welcome original research articles, reviews, and short communications that explore the molecular, cellular, and translational aspects of lung injury and repair. Contributions that provide new insights into the mechanisms of acute and chronic lung injury, highlight potential therapeutic targets, or advance our understanding of disease progression and recovery are especially encouraged. Submissions addressing innovative experimental models, biomarkers, or clinical applications are also highly valued.
Dr. Weiguo Chen
Dr. HongLong Ji
Dr. Ibra S. Fancher
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- acute lung injury
- chronic lung injury
- ARDS
- fibrosis
- allergy
- mechanisms
- therapy
- infection
- inflammation
- endothelial barrier
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