Genetics and Epigenetics of Neurological Disorders

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 552

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Guest Editor
Neurology Clinic, University Clinical Center of Serbia, 11000 Belgrade, Serbia
Interests: neurogenetics; neurodegenerative disorders; movement disorders; neuromuscular; mitochondrial disorders
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Special Issue Information

Dear Colleagues,

This Special Issue, entitled Genetics and Epigenetics of Neurological Disorders, will highlight current advances in our understanding of the genetic architecture and regulatory mechanisms contributing to neurological diseases, ranging from rare monogenic forms to complex neurodegenerative conditions.

Neurological disorders encompass a wide spectrum of conditions that affect the central and peripheral nervous systems, and advances in genomics and epigenomics are transforming our understanding of the molecular mechanisms underlying these diseases.

Beyond identifying single pathogenic variants, research has increasingly focused on complex genetic interactions, modifier genes, and epigenetic regulation that influence disease onset, progression, and clinical heterogeneity. Epigenetic mechanisms play a crucial role in shaping neuronal gene expression, plasticity, and response to environmental factors. Integrating genomic, transcriptomic, and epigenomic data provides valuable insights into pathogenic pathways and creates new opportunities for biomarker discovery and targeted therapies.

This Special Issue will collect recent studies and comprehensive reviews in this field to promote the translation of molecular findings into clinical practice for improved diagnosis, prognosis, and treatment.

Dr. Milena Janković
Guest Editor

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Keywords

  • neurological disorders
  • neurogenetics
  • genomics
  • epigenomics
  • DNA methylation
  • precision medicine

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Published Papers (1 paper)

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Research

18 pages, 543 KB  
Article
Association Between Multiple Sclerosis Severity and Functional Variants in Key Antioxidant Defense and Ferroptosis-Related Genes
by Tamara Djuric, Jovana Kuveljic, Ana Djordjevic, Milan Stefanovic, Evica Dincic, Mariana Seke, Aleksandra Stankovic and Maja Zivkovic
Biology 2026, 15(10), 773; https://doi.org/10.3390/biology15100773 - 12 May 2026
Viewed by 259
Abstract
Multiple sclerosis (MS) is a chronic, progressive, inflammatory neurodegenerative disease. Oxidative stress and ferroptosis are implicated in MS pathology, contributing to both inflammation and neurodegeneration. Potentially functional variants in genes related to antioxidant defense and ferroptosis were chosen through an extensive selection process [...] Read more.
Multiple sclerosis (MS) is a chronic, progressive, inflammatory neurodegenerative disease. Oxidative stress and ferroptosis are implicated in MS pathology, contributing to both inflammation and neurodegeneration. Potentially functional variants in genes related to antioxidant defense and ferroptosis were chosen through an extensive selection process to investigate their possible association with the progressive form of MS. The study included 845 MS patients (604 relapsing–remitting (RRMS) and 241 progressive (PMS)). The selected gene variants—GCLC rs572496, GCLM rs2273406, GPX4 rs713041, NQO1 rs1800566 and CAT rs2420388—were genotyped using TaqMan® technology. mRNA expression levels of the corresponding genes in PBMCs were previously determined by targeted RNA sequencing. Circulatory molecular indicators of antioxidant defense and ferroptosis were quantified using ELISA and colorimetric enzymatic recycling assays. The findings indicate that the GCLC rs572496 variant was significantly associated with MS disease severity and had a significant effect on GCLC mRNA levels. Additionally, the NQO1 rs1800566 variant had a significant effect on NQO1 mRNA expression in PBMCs of MS patients overall. The results suggest further analysis of antioxidant defense and ferroptosis-related gene variants with MS severity and validation of the gained results in larger study groups. Full article
(This article belongs to the Special Issue Genetics and Epigenetics of Neurological Disorders)
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