Genetics and Epigenetics of Neurological Disorders

Dear Colleagues,

This Special Issue, entitled Genetics and Epigenetics of Neurological Disorders, will highlight current advances in our understanding of the genetic architecture and regulatory mechanisms contributing to neurological diseases, ranging from rare monogenic forms to complex neurodegenerative conditions.

Neurological disorders encompass a wide spectrum of conditions that affect the central and peripheral nervous systems, and advances in genomics and epigenomics are transforming our understanding of the molecular mechanisms underlying these diseases.

Beyond identifying single pathogenic variants, research has increasingly focused on complex genetic interactions, modifier genes, and epigenetic regulation that influence disease onset, progression, and clinical heterogeneity. Epigenetic mechanisms play a crucial role in shaping neuronal gene expression, plasticity, and response to environmental factors. Integrating genomic, transcriptomic, and epigenomic data provides valuable insights into pathogenic pathways and creates new opportunities for biomarker discovery and targeted therapies.

This Special Issue will collect recent studies and comprehensive reviews in this field to promote the translation of molecular findings into clinical practice for improved diagnosis, prognosis, and treatment.

Dr. Milena Janković
Guest Editor

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