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Biology
Special Issues
Bone Physiology and Development
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Bone Physiology and Development

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 884

Editors

Dr. Silviya Nikolova

E-Mail Website
Guest Editor
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: skeletal biology; bone physiology; anatomy; medical anthropology; osteology
Dr. Diana Toneva

E-Mail Website
Guest Editor
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: osteology; skeletal biology; bone biology; bone physiology; biomedical imaging; human anatomy
Dr. Yohei Abe

E-Mail Website
Guest Editor
Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA
Interests: cellular and molecular medicine; bone; osteoclast; osteoblast; osteocyte; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The osseous tissue is the main constructive entity of the skeleton, which provides support and protection for other tissues and organs, assists movement, and functions as a site for blood cell formation and mineral storage. It is a living tissue that responds to various intrinsic and extrinsic factors and specific demands by dynamic remodeling. Accumulation of knowledge on bone biology is essential for a better understanding of the normal functioning and pathological processes in this specific mineralized connective tissue. The research area of this Special Issue encompasses osteology and bone development and physiology. It includes, but is not limited to, studies on bone formation and growth, bone structure, functioning, morphology, composition, remodeling, variations, and diseases on different levels of organization (cells, bone tissue, bones, and skeleton). 

We look forward to your contributions.

Dr. Silviya Nikolova
Dr. Diana Toneva
Dr. Yohei Abe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteology
  • osteogenesis
  • bone growth
  • bone physiology
  • bone morphology
  • bone pathology
  • bone imaging

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Published Papers (1 paper)

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Research

17 pages, 721 KB  
Article
Effects of Type I Diabetes Mellitus and Masticatory Loading on Mandibular Growth in Growing Rats: A Longitudinal CBCT Study
by Nearchos Panayi, Ismene A. Dontas, Efstathios Chronopoulos, Georgios Kanavakis, Ioannis A. Tsolakis, Georgia Kotantoula, Konstantina Eleni Alexiou, Zafeiroula Yfanti, Orestis Koutras and Apostolos I. Tsolakis
Biology 2026, 15(12), 979; https://doi.org/10.3390/biology15120979 - 22 Jun 2026
Viewed by 484
Abstract
Background: Craniofacial growth is regulated by a complex interaction of genetic, functional, and systemic metabolic factors. Mechanical loading generated during mastication plays a fundamental role in mandibular development through bone modeling and remodeling mechanisms. In contrast, Type I diabetes mellitus is associated with [...] Read more.
Background: Craniofacial growth is regulated by a complex interaction of genetic, functional, and systemic metabolic factors. Mechanical loading generated during mastication plays a fundamental role in mandibular development through bone modeling and remodeling mechanisms. In contrast, Type I diabetes mellitus is associated with impaired bone metabolism, which may compromise skeletal growth. Although the independent effects of functional loading and metabolic disorders on bone tissue have been widely investigated, their combined influence on mandibular development remains insufficiently understood. Objective: This study primarily aimed to evaluate the effect of Type I diabetes mellitus on mandibular growth in growing rats and, secondarily, to assess the impact of dietary consistency (hard versus soft food) on mandibular development under diabetic and non-diabetic conditions, as well as determine whether diabetes modifies the mandibular adaptive response to increased masticatory loading. Materials and Methods: An experimental animal study was conducted using twenty-four male Wistar rats aged one month. The animals were randomly allocated into four groups according to metabolic status (control or diabetic) and dietary consistency (hard or soft diet). Type I diabetes mellitus was experimentally induced in the relevant groups using streptozotocin. All animals underwent cone beam computed tomography (CBCT) scanning at baseline (Day 1) and at the end of the experimental period (Day 28). Linear measurements were obtained using specialized software following euthanasia. Two-way ANOVA was used to evaluate the effects of diabetes, diet, and their interaction, using appropriate post hoc tests for multiple comparisons. Categorical variables were analyzed using the chi-square test. A p-value < 0.05 was considered statistically significant. Results: Longitudinal morphometric analysis demonstrated that Type I diabetes mellitus significantly impaired mandibular growth. Diabetic animals exhibited reduced growth rates and smaller final mandibular dimensions compared with controls. Hard diet intake significantly enhanced mandibular development in control animals, reflecting a strong adaptive response to increased functional loading. However, this osteogenic response was markedly attenuated in diabetic rats. Under soft-diet conditions, differences between control and diabetic groups were diminished, indicating that reduced mechanical stimulation limits adaptive growth responses. Significant interaction effects between diabetes and dietary consistency were observed in several morphometric parameters, particularly those related to mandibular body length, ramus height, and condylar position. Conclusions: Type I diabetes mellitus exerts a detrimental effect on mandibular growth in growing rats and compromises the adaptive response of craniofacial structures to mechanical loading. Although a hard diet functions as a potent osteogenic stimulus, its growth-promoting effect is substantially reduced in the presence of metabolic dysfunction. Full article
(This article belongs to the Special Issue Bone Physiology and Development)
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