Brain Organoids: Construction, Analysis, and Application
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 31 October 2026 | Viewed by 19
Special Issue Editor
Interests: brain organoids; iPSCs; neurodevelopmental disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent advances in stem cell biology and 3D culture systems have led to the development of brain organoids—miniaturized, self-organizing models that recapitulate key aspects of human brain development and function. These models offer unique opportunities to study complex neurodevelopmental and neurodegenerative diseases, especially those that are difficult to model using traditional in vitro or in vivo systems. Brain organoids have rapidly become indispensable tools in neuroscience, providing insights into early brain development, disease mechanisms, and responses to therapeutics. This Special Issue will highlight the growing importance of brain organoid research in biomedical science and translational medicine.
This Special Issue will showcase cutting-edge research and methodological advances in the generation, characterization, and application of brain organoids. It will bring together interdisciplinary work that aligns with the journal’s scope, covering regenerative medicine, disease modeling, and stem cell-based technologies. By focusing on both fundamental biology and translational potential, this Special Issue will serve as a platform for sharing the latest innovations and conceptual developments in the brain organoid field.
For this Special Issue, we welcome the submission of original research articles and reviews. Topics of interest include (but are not limited to) the following:
- Protocols for generating whole-brain or region-specific organoids;
- Single-cell and spatial transcriptomics in organoid analysis;
- Modeling neurodevelopmental and neurodegenerative disorders using brain organoids;
- Patient-derived iPSC-based disease models;
- Electrophysiological and functional analyses of brain organoids;
- Integration of organoids into bioengineering platforms (e.g., organ-on-chip, bioprinting);
- Drug screening and personalized medicine applications.
I look forward to receiving your contributions.
Dr. Jonghun Kim
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- brain organoids
- iPSCs
- neurodevelopmental disorders
- region-specific organoids
- functional neuronal analysis
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