Pathogenesis and Immune Evasion of Mycobacteria in Mammals
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 1148
Special Issue Editors
Interests: bovine TB
Interests: Mycobacterium bovis
Special Issue Information
Dear Colleagues,
Mycobacteria encompass a diverse group of pathogens capable of infecting a wide range of mammalian hosts, including humans, livestock, and wildlife. Their success as pathogens lies in their remarkable ability to persist within host tissues, often establishing chronic or latent infections. Species such as Mycobacterium tuberculosis and Mycobacterium bovis have evolved sophisticated mechanisms to subvert host immune responses, enabling survival within macrophages, evasion of bactericidal pathways, and modulation of adaptive immunity. These strategies contribute not only to disease progression and transmission but also to major challenges in vaccine development and therapeutic interventions.
Understanding the molecular and cellular basis of mycobacterial pathogenesis and immune evasion is crucial to improving diagnostics, vaccines, and host-directed therapies. Recent advances in genomics, transcriptomics, and immunology have shed light on host–pathogen interactions, revealing potential targets for intervention. Moreover, studying mycobacterial infections in non-human mammals provides valuable insights into cross-species transmission dynamics, zoonotic risks, and comparative immunology.
This Special Issue aims to bring together cutting-edge research on the pathogenic strategies of mycobacteria and their interactions with mammalian immune systems. We welcome contributions spanning molecular mechanisms, host–pathogen interactions, animal models, and translational research to advance our understanding and inform future control strategies.
Dr. Federico Carlos Blanco
Dr. Cristina Lourdes Vázquez
Guest Editors
Manuscript Submission Information
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Keywords
- mycobacteria
- pathogenesis
- immune evasion
- host–pathogen interactions
- latency
- zoonotic transmission
- comparative immunology
- vaccine development
- host-directed therapies
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