Novel Mechanisms and Biological Processes in Redox and Inflammatory Signaling

A Special Issue of Biology (ISSN 2079-7737) belonging to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: closed (31 August 2026) | Viewed by 1183

Editors

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue of Biology, focused on elucidating the fundamental mechanisms linking redox imbalance to inflammatory processes. The dynamic interplay between oxidative stress and inflammatory signaling is a fundamental cellular phenomenon, critical for maintaining homeostasis and orchestrating stress responses across biological systems. This Special Issue calls for original research and review articles that uncover novel mechanistic insights at the molecular, cellular, and organismal levels. Our goal is to create a comprehensive resource that highlights the future direction of basic research in redox and inflammatory biology.

We encourage submissions that explore innovative angles, including the discovery of new molecular targets, the application of advanced technologies, and the investigation of cross-species conservation of these pathways.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Novel signaling axes: Discovery of non-canonical pathways (e.g., lactate, gasotransmitters) linking reactive species to NF-κB, NLRP3, and other inflammatory mediators
  • Organelle communication: The role of mitochondrial-ER crosstalk, lysosomal function, and extracellular vesicles in redox-inflammatory signaling.
  • Metabolic inflammation (Metaflammation): How nutrient-sensing pathways and metabolic rewiring drive inflammatory processes.
  • The gut–microbiota axis: Interactions between host redox state, gut microbiota, and systemic inflammation.
  • Epigenetic regulation: How oxidative stress influences inflammation through DNA methylation, histone modification, and non-coding RNAs.
  • Cross-species comparative studies: Mechanistic insights from animal models with translational relevance to human diseases.

By fostering a platform for high-quality fundamental research, we aspire to deepen our understanding of the core principles governing redox and inflammatory signaling, and to reveal new layers of complexity in cellular communication and adaptation.

Dr. Shengchen Wang
Prof. Dr. Demin Cai
Guest Editors

Manuscript Submission Information

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Keywords

  • redox
  • inflammatory
  • oxidative stress
  • antioxidant
  • anti-inflammatory
  • signaling pathways

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Published Papers (1 paper)

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Review

23 pages, 7475 KB  
Review
Ionic Gelation for Nano-Delivery of Sulforaphane in Animal Feed: A Conceptual Review of Stability, Efficacy, and Translation Potential
by Kevaun Altamon George Wilson, Mengke Zhang, Yiming Shen, Mukesh Kumar, Sandreika Osheika Laird, Salwa Eman, Jun Xu, Haibing Li, Mengzhi Wang and Xiaodong Guo
Biology 2026, 15(13), 1045; https://doi.org/10.3390/biology15131045 - 30 Jun 2026
Viewed by 676
Abstract
Sulforaphane (SFN), a bioactive compound sourced from cruciferous vegetables, offers significant antioxidant and anti-inflammatory benefits yet its stability in animal feed is a challenge. Nanotechnology-based encapsulation, specifically ionic gelation, has demonstrated efficacy in improving the stability and bioavailability of SFN. This review examines [...] Read more.
Sulforaphane (SFN), a bioactive compound sourced from cruciferous vegetables, offers significant antioxidant and anti-inflammatory benefits yet its stability in animal feed is a challenge. Nanotechnology-based encapsulation, specifically ionic gelation, has demonstrated efficacy in improving the stability and bioavailability of SFN. This review examines the application of natural polymers such as chitosan and alginate in ionic gelation for the encapsulation of SFN. It also discusses how these polymers can prevent SFN from degrading while traversing the digestive tract. Encapsulation strategies for SFN have been associated with improved bioavailability, with absorption reported in experimental modules, to modulate immune-related and oxidative-stress pathways. However, challenges persist in identifying optimal methods for encapsulating various species, including enhancing encapsulation effectiveness, particle size, and controlled release mechanisms. Additionally, regulatory concerns regarding the safety and environmental impacts of nanoparticles in feed must be addressed. Future research should focus on improving encapsulation techniques and ensuring the safe application of SFN-loaded nanocarriers in livestock feed. Full article
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