2026 January-1 - 105 articles
Background: Plant citrate synthase (CSY) is involved in the iron deficiency (−Fe) response and aluminum (Al) detoxification. However, knowledge of CSY function in responding to excess iron (+Fe) or Al stress (+Al) is still limited. Methods: The...
Foodborne pathogens remain a global public health concern, and antimicrobial resistance increases their impact. In mass-gathering cities such as Al-Madinah Al-Munawarah, contaminated ready-to-eat (RTE) fast foods can contribute to both local transmis...
Wildlife conservation and the management of biological resources face unprecedented challenges in the Anthropocene [...]
Manganese (Mn) is a crucial micronutrient for plants. The impaired function of the oxygen-evolving complex in Photosystem II (PSII) due to Mn deficiency is believed to result in the overproduction of reactive oxygen species and the induction of an en...
Niclosamide has been the primary molluscicide for schistosomiasis control for over 50 years, but its chronic effects on inter-organ interactions in non-target mollusks remain poorly understood. Cipangopaludina cathayensis, a dominant species in East...
The Kazakh horse is an outstanding dual-purpose dairy and meat breed in China, characterized by early maturity, tolerance to coarse feed, and strong stress resistance. Previous studies have examined gene expression patterns in the testicular tissues...
Microalgae are an evolutionarily ancient and morphologically diverse group of photosynthetic eukaryotes, with taxonomic resolution complicated by environmentally driven phenotypic plasticity. This study merges deep learning and explainable artificial...
Amphibians are among the most threatened vertebrate groups globally, with over 40% of species at risk of extinction. However, a gap remains in understanding how to effectively develop and implement amphibian conservation strategies at local and globa...
Fast-twitch and slow-twitch muscle fibers not only differ in metabolic characteristics and physiological functions but also significantly influence the texture of livestock meat. RNA editing represents an important post-transcriptional regulatory pro...
Chagas disease remains a major public health challenge due to the limited effectiveness and considerable side effects of existing treatments, particularly during the chronic stage. Açaí (Euterpe oleracea) seeds have gained increasing at...
Hepatocellular carcinoma (HCC) ranks among the top causes of cancer-related mortality worldwide, and its complex tumor microenvironment (TME) contributes to poor responses to immunotherapy. Although PD-1/PD-L1 blockade has emerged as an effective tre...
My article criticizes the view held by many ecologists that species have evolved essentially equivalent levels of fitness, thus permitting their coexistence. I show that a recently proposed version of this view called the “equal fitness paradig...
Chinese tongue sole (Cynoglossus semilaevis) is an important marine aquaculture species that exhibits pronounced female-biased sexual size dimorphism, which limits the economic value of male stocks. The F4 generation of genome-edited dmrt1−/&mi...
Uterine leiomyomas or fibroids, are non-cancerous smooth muscle proliferations of the uterus, occurring mostly in women of reproductive age. Their pathogenesis involves complex growth factor interactions that regulate cellular proliferation, extracel...
Sweetpotato genotypes, often known by regional names, are easily propagated via cuttings, which can lead to mixing and misidentification of cultivars. This complicates traceability and commercialization. Accurate characterization of common genotypes...
Obesity plays a crucial role in the progression of insulin resistance and type 2 diabetes which are related to inflammation and liver disease. GATA-3 is a transcription factor that is involved in adipogenesis and inflammation. Therefore, it could be...
By regulating gene expression to maintain homeostasis and enabling rapid responses to environmental change, epigenetic mechanisms can provide valuable insights into how populations respond to external pressures. Here, we examined genome-wide DNA meth...
The immune system comprises a complex network of cells that continuously change during activation, infection, and the maintenance of balance. Immunophenotyping offers valuable insights into the regulation of immune responses. We systematically charac...
The bioaccessibility of flavonoids (namely, their release from the food matrix and their stability under gastrointestinal conditions) is pivotal in establishing their bioavailability and biological effects. Bioaccessibility is affected by several fac...
Recent studies have demonstrated that the abundance of brown adipose tissue is inversely associated with obesity in humans. Promoting the browning of white adipocytes therefore represents a promising therapeutic strategy for obesity treatment. LncRNA...
The Metabolic Theory of Ecology (MTE) proposes universal constants for the scaling of metabolic rate (BMR) with body mass and temperature. However, the validity of these constants across different biological hierarchies, specifically within versus be...
Mitochondrial energy metabolism is fundamental to sperm function, and fatty acid β-oxidation is an important pathway for adenosine triphosphate (ATP) production. Riboflavin, a precursor of key flavin cofactors, plays a critical role in regulatin...
Biogas and methane generated from the anaerobic digestion (AD) of organic waste present a highly effective alternative to fossil fuels. The study assessed using dragon fruit peel (DFP) as a co-substrate to enhance chicken manure (CM) biodegradability...
In arid regions, the ecological restoration of limestone tailings requires sustainable strategies, yet the synergistic effects of substrate optimization and native plant selection remain poorly understood. In this study, we systematically evaluated s...
Acute myocardial infarction (AMI) is a significant factor leading to the death of patients with coronary heart disease. Both AMI and reperfusion therapy after AMI cause myocardial cell death, which plays a significant role in heart failure. Following...
Global CO2 concentrations are gradually increasing, and forests, as the main terrestrial carbon pool, are attracting growing attention in mitigating climate change. However, the impacts of forest types, species diversity, structural diversity, and en...
Feeding Chinese mitten crabs with fresh-frozen fish causes nutritional imbalance and increases disease risk. Compound feed offers better nutrient balance but still requires improvements in palatability and growth performance. This study evaluated the...
Entomopathogenic nematodes (EPNs), including Steinernema and Heterorhabditis, are obligate insect parasites widely used in biological pest control. However, their efficacy is often limited by susceptibility to environmental stresses like desiccation....
Cytochrome P450 (CYP450) monooxygenases are a class of enzymes containing conserved heme-binding functional domain. They contribute to a wide range of biosynthetic processes, serving a pivotal function in plant resistance to abiotic stress. To date,...
Chronic HBV infection remains a global health challenge, driving liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Liver injury is primarily mediated by host immune responses rather than direct viral cytotoxicity. Macrophages, including...
This study analyzed the photosynthetic traits of 74 sugarcane genotypes using PAM-2500 and SPAD instruments over three years. Our findings revealed significant variations in photosynthetic characteristics among different genotypes and ratoon years, h...
Leaf abscission is a cell separation process that occurs throughout the entire plant life cycle, leading to the detachment of tissues or organs. The application of chemical defoliants to induce cotton leaf abscission not only saves the energy require...
Obtaining reliable estimates of population sizes and their temporal trends is essential for assessing the conservation status and guiding the management of threatened species. Parrots (order Psittaciformes) are among the most diverse yet most threate...
The identification of mRNA isoforms in biological samples is crucial for studying tissue- and cell-specific isoform expression, activity of tissue-specific promoters, alternative splicing events, and alternative polyadenylation signals in genes. For...
This study investigates the bacterial community structure and diversity across different root compartments (non-rhizosphere soil, rhizosphere soil, rhizosphere, and endosphere) of Camellia oleifera and their associations with three cultivars (‘...
Over the years, neurons undergo functional changes initially linked to the maturation of the brain and then are progressively linked to normal aging. The curious relationship between brain decay, aging, and neuronal diseases has aroused the interest...
Bats provide essential ecosystem services, particularly in regulating insect populations within agricultural landscapes. However, research on bat–insect interactions in Malaysian rice fields remains limited. This study examined bat diversity an...
Despite decades of structural and kinetic characterization, the full spectral molecular vibrations that accompany the catalysis in alkaline phosphatase (ALP) have remained largely unexplored. In this study, we combine in situ real-time attenuated tot...
Ferroptosis is a non-apoptotic, iron-dependent form of cell death. The characteristic accumulation of membrane lipid peroxides that occurs is controlled by several different mechanisms including redox homeostasis, the intracellular labile iron pool,...
As a coastal brush, Atalantia buxifolia is a good rootstock of citrus plants around sea shores, but its salt tolerance has not been studied. In order to explore the salt tolerance of A. buxifolia, its seeds and seedlings were subjected to NaCl stress...
Autism spectrum disorder (ASD) arises from complex genetic and environmental influences. Despite its prevalence and being the focus of study for several decades, its causes and their underlying mechanisms are still not fully understood. However, one...
Small-grained rice varieties are highly valued in hybrid seed production and food markets because of their unique advantages in mechanized seed production and cooking qualities. Developing new varieties combining small grain size with high nutritiona...
Weissella viridescens has been proposed as a probiotic candidate, but strain-level multi-omics evidence remains limited. The complete genome of the human-derived W. viridescens strain Wv2365 was sequenced through a hybrid assembly of Illumina and Pac...
To clarify microbial assembly during saline–alkali wetland degradation, we analyzed bacterial (16S rRNA) and fungal (ITS) communities across four habitats: pristine wetland (PW), transitional meadow wetland (TMW), halophytic herbaceous communit...
We present LazyNet, a compact one-step neural-ODE model for single-cell CRISPR activation/interference (A/I) that operates directly on two-snapshot (“pre → post”) measurements and yields parameters with clear mechanistic meaning. The...
The oleaginous yeast Rhodotorula glutinis is a promising industrial host for the simultaneous production of lipids and carotenoids, yet the transcriptional regulation governing carbon flux toward these metabolites is poorly understood. As a foundatio...
Transposable elements (TEs) constitute a significant portion of eukaryotic genomes and play crucial roles in genome evolution, yet their diverse and complex sequences pose challenges for accurate classification. Existing tools often lack reliability...
Sex differences in stress response continue to be understudied in basic physiological and behavioral research. The current study aimed to investigate the sex-specific effects of chronic stress in wild-derived house mice subjected to chronic unpredict...
Serine proteases represent a significant family of proteolytic enzymes, characterized by their serine-dependent catalytic mechanism. These enzymes are integral to various biological processes, including fungal growth, development, and pathogenicity....
Aging is an inevitable biological process that affects the function of various organs, including the immune system. Immunosenescence is characterized by diminished immune cell function, weakened immune responses, and imbalances in immune components,...
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