Large Animal Experimental and Epidemiological Models for Diseases

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 670

Special Issue Editors


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Guest Editor
1. Veterinary Academic Office, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand 2. Overseas Division Cambodia Office, Asian Satellite Campuses Institute, Nagoya University, Nagoya 464-8601, Japan
Interests: experimental animal models for diseases and therapeutic sciences; transmission mathematical models and population dynamics of infectious diseases; understanding the links among epidemiology, physiology, immunology, and pathobiology of disease; antimicrobial resistance; animal environment models of emerging and re-emerging diseases

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Guest Editor
Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Nagoya 464-8601, Japan
Interests: neuroendocrine reproductive science; cellular and molecular mechanisms regulating neuronal activities; kisspeptin neurons as a key player bridging the endocrine system and sexual behavior in mammals

Special Issue Information

Dear Colleagues,

Animal models play a crucial role in the study of both infectious and non-infectious diseases, enabling researchers to replicate disease processes and test interventions in a controlled environment. Large experimental animal models, such as dogs, pigs, sheep, and non-human primates, are increasingly used in biomedical research because they bridge the gap between small animal models and humans. They offer better anatomical and physiological similarities to humans, particularly for non-infectious diseases such as cardiovascular, metabolic, reproductive, genetic, and neurodegenerative conditions. These models facilitate more accurate and relevant testing of new therapies and treatments, supporting long-term studies and clinical dosing regimens. In public health and livestock management, large animal epidemiological models represent disease transmission dynamics among animals and humans. They help in evaluating control measures and predicting outcomes in infectious and zoonotic diseases, as well as antibiotic resistance. Livestock serve as valuable models in studying human diseases, enabling research on disease dynamics, treatment testing, and vaccine development.

This Special Issue will showcase reviews and original research articles that provide up-to-date information and future perspectives on large animal experimental and epidemiological models of diseases, with possible topics including (but not limited to) prevention, pathobiology, diagnosis, prediction, treatment, outbreaks, and control.

We look forward to receiving your contributions.

Prof. Dr. Witaya Suriyasathaporn
Dr. Sho Nakamura
Guest Editors

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Keywords

  • large animal model
  • dog
  • pig
  • ruminants
  • experimental study
  • epidemiological study
  • infectious diseases
  • non-infectious diseases
  • treatment
  • disease control
  • disease prediction

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Published Papers (1 paper)

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Research

13 pages, 16003 KiB  
Article
Bacterial Pathogens of Bovine Mastitis: Prevalence, Antimicrobial Susceptibility, and Sensitivity to Caesalpinia sappan Both In Vitro and In Vivo Studies
by Phacharaporn Tadee, Wiwat Pattanawong, Apichart Manwicha, Pakasinee Khaodang, Doungporn Amornlerdpison, Sunee Chansakaow, Pramote Tipduangta, Kridda Chukiatsiri and Pakpoom Tadee
Biology 2025, 14(4), 350; https://doi.org/10.3390/biology14040350 - 27 Mar 2025
Viewed by 431
Abstract
Mastitis is a major infectious disease that causes significant economic losses in the dairy industry. Current control programs primarily rely on antimicrobials, contributing to the growing concerns of the resistance situation and drug residues in milk. This study aimed to identify the bacterial [...] Read more.
Mastitis is a major infectious disease that causes significant economic losses in the dairy industry. Current control programs primarily rely on antimicrobials, contributing to the growing concerns of the resistance situation and drug residues in milk. This study aimed to identify the bacterial pathogens responsible for subclinical/clinical bovine mastitis, assess their antimicrobial resistance profiles, and evaluate the antimicrobial effects of Caesalpinia sappan in treating mastitis through both in vitro and in vivo studies. A total of 138 bacterial isolates, representing 40 species, were identified from 100 milk samples collected from dairy cows under the Maejo Cooperative Group in Chiang Mai, Thailand, between May 2021 and February 2022. The most prevalent species was Escherichia coli (10.87%), followed by Bacillus cereus (9.42%) and Staphylococcus sciuri (7.97%). The highest resistance rates were observed for penicillin (65.21%), followed by streptomycin and lincomycin (61.59%). Nine isolates resisted all 18 antimicrobials tested. The average minimum inhibitory concentration (MIC) of C. sappan against the identified pathogens ranged from 0.63 to 17.68 mg/mL, with the highest MIC observed against Pseudomonas luteola. In the animal experiment, treatment with a prototype of an intramammary infusion compound primarily formulated from C. sappan significantly reduced the total bacterial count and California Mastitis Test (CMT) scores (p < 0.01). These results suggest that C. sappan exhibits antimicrobial efficacy against various mastitis bacteria and could serve as a potential alternative treatment to control bovine mastitis in dairy cattle within the study region. Full article
(This article belongs to the Special Issue Large Animal Experimental and Epidemiological Models for Diseases)
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