Transcriptional Regulation in Eukaryotes
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 265
Special Issue Editor
Special Issue Information
Dear Colleagues,
Eukaryotic transcription regulation involves complex, dynamic processes ensuring timely and specific gene expression across diverse cell types and signals. These processes encompass chromatin accessibility, epigenetic modifications, and the interaction of transcription factors (TFs) with DNA and other TFs and coregulators. They also include the formation of large multi-protein complexes at regulatory elements, dynamic long-range genomic contacts (e.g., between promoters and enhancers or silencers), 3D chromatin architecture, and non-coding RNAs.
Advancements in genome-wide cistrome, transcriptome, and chromatin connectome datasets, combined with gene perturbation studies and precision imaging techniques, have greatly enhanced our understanding of these mechanisms. However, challenges persist. Current models often provide static snapshots rather than dynamic views of gene activity. The precise mechanistic link between transcriptional processivity and enhancer–promoter contacts, as well as the molecular determinants of contact specificity, remain unresolved. The role of phase-separable biomolecular condensates in organizing and regulating transcription in vivo is emerging, though further evidence is needed.
Future challenges include integrating diverse multi-omics datasets to construct comprehensive models of transcription regulation specific to cell types and signals and understanding the impact of disease-related mutations on these processes. Single-cell technologies and machine learning approaches are crucial for analyzing large-scale data and inferring regulatory relationships with greater precision.
This Special Issue aims to cover various aspects of eukaryotic transcription regulation. We welcome original research and review articles that provide new insights into these processes, as well as articles describing novel methods.
Dr. Anil Kumar Panigrahi
Guest Editor
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Keywords
- transcription factors (TFs)
- transcriptional coregulators
- RNA polymerase II
- chromatin modifications and remodeling
- enhancers
- silencers
- non-coding RNAs
- 3D chromatin architecture
- multi-omics integration
- single-cell technologies
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