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bis(2-Phenylpyridinato)-[4,4′-bis(iodoethynyl)-2,2′-bipyridine]-iridium(III) Hexafluorophosphate
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Benzyl-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]carbamate
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1,3,4,5-Tetra-O-benzoyl-α-d-tagatopyranose
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3-Methyl-2-((methylthio)methyl)but-2-enal
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(Z)-2-(Bromomethyl)-3-(hydroxymethylene)-7-methoxy-5-methyl-2-(tribromomethyl)-4-chromanone
Journal Description
Molbank
Molbank
is an international, peer-reviewed, open access journal comprised of a unique collection of one-compound-per-paper short notes on synthetic compounds and natural products published quarterly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), Reaxys, CAPlus / SciFinder, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 14.7 days after submission; acceptance to publication is undertaken in 2.8 days (median values for papers published in this journal in the first half of 2025).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
0.4 (2024)
Latest Articles
1,1-Bis(4-ethylphenyl)-propan-1,2-diol
Molbank 2025, 2025(4), M2076; https://doi.org/10.3390/M2076 (registering DOI) - 16 Oct 2025
Abstract
Diols represent a structurally diverse class of compounds with considerable biological and functional significance. Herein, we describe the synthesis of 1,1-bis(4-ethylphenyl)propan-1,2-diol (BEPP) via a Grignard reaction. The structure of BEPP was unambiguously elucidated by 1H and 13C nuclear magnetic resonance (NMR),
[...] Read more.
Diols represent a structurally diverse class of compounds with considerable biological and functional significance. Herein, we describe the synthesis of 1,1-bis(4-ethylphenyl)propan-1,2-diol (BEPP) via a Grignard reaction. The structure of BEPP was unambiguously elucidated by 1H and 13C nuclear magnetic resonance (NMR), heteronuclear multiple-bond correlation (HMBC), high-resolution mass spectrometry (HRMS), and infrared (IR) spectroscopy.
Full article
(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
3-((Benzyloxy)carbonyl)bicyclo[1.1.1]pentane-1-carboxylic Acid
by
Dennis D. Toporkov, Stacie K. Nelson, Jean-Denys Hamel and René T. Boeré
Molbank 2025, 2025(4), M2075; https://doi.org/10.3390/M2075 (registering DOI) - 16 Oct 2025
Abstract
The compound 3-((benzyloxy)carbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid was successfully synthesized. High-quality crystals were obtained, and its X-ray structure was solved and refined by Hirshfeld atom refinement using custom aspherical scattering factors with the Olex2/NoSphereA2 package. Hydrogen bonding interactions lead to head-to-head carboxylic acid dimer formation. A
[...] Read more.
The compound 3-((benzyloxy)carbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid was successfully synthesized. High-quality crystals were obtained, and its X-ray structure was solved and refined by Hirshfeld atom refinement using custom aspherical scattering factors with the Olex2/NoSphereA2 package. Hydrogen bonding interactions lead to head-to-head carboxylic acid dimer formation. A positional disorder for the bridging H-atom was detected and modeled to two parts in a 0.85:0.15 ratio. Detailed comparison with a neutron diffraction study of benzoic acid at the same temperature (100 K) demonstrates that the E–H-bond distances in the title compound are in excellent agreement (differing less than 1%) and the displacement ellipsoids volumes to the model are also in excellent agreement to the neutron diffraction structure. Moreover, both the variation in refined disorder occupancy and differences in C=O and C–O lengths of the disordered carboxylic acids in the two structures track well with their dimer O···O separations. This is longer by 0.023 Å in the structure of the title compound than in that of benzoic acid. A database search was conducted and used for comparison of the title compound to other high-quality structures of bicyclo[1.1.1]pentane-containing species.
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(This article belongs to the Section Structure Determination)
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Open AccessShort Note
(5R*,6R*) 11-Benzoyl-4,10-dimethyl-2,8-diphenyl-2,3,8,9-tetraazadispiro [4.0.46.15]undeca-3,9-diene-1,7-dione
by
Michail N. Elinson, Varvara M. Kalashnikova, Yuliya E. Ryzhkova and Oleg A. Rakitin
Molbank 2025, 2025(4), M2073; https://doi.org/10.3390/M2073 (registering DOI) - 15 Oct 2025
Abstract
Cyclopropanes are important in drug discovery because their unique structure, including inherent three-dimensionality, can enhance a drug’s properties, such as metabolic stability, target binding, and membrane permeability. In this communication, (5R*,6R*) 11-benzoyl-4,10-dimethyl-2,8-diphenyl-2,3,8,9-tetraazadispiro[4.0.46.15]undeca-3,9-diene-1,7-dione was prepared via
[...] Read more.
Cyclopropanes are important in drug discovery because their unique structure, including inherent three-dimensionality, can enhance a drug’s properties, such as metabolic stability, target binding, and membrane permeability. In this communication, (5R*,6R*) 11-benzoyl-4,10-dimethyl-2,8-diphenyl-2,3,8,9-tetraazadispiro[4.0.46.15]undeca-3,9-diene-1,7-dione was prepared via a stereoselective one-pot reaction of phenylglyoxal hydrate with two equivalents of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one in EtOH in the presence of sodium acetate and N-bromosuccinimide. The structure of the newly synthesized compound was established by 1H and 13C NMR, IR spectroscopy, high-resolution mass spectrometry, and elemental analysis.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessCommunication
Efficient Synthesis of Unsymmetrical 7,7′-Biindolizines
by
Roxana Ciorteanu, Andreea Danila, Catalina Ionica Ciobanu, Ioana Radu, Ionel I. Mangalagiu and Ramona Danac
Molbank 2025, 2025(4), M2074; https://doi.org/10.3390/M2074 (registering DOI) - 15 Oct 2025
Abstract
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Six new unsymmetrical 7,7′-biindolizines were synthesized through an efficient metal-free [2+2+1] cycloaddition of ethyl 3-benzoyl-7-(pyridin-4-yl)indolizine-1-carboxylate with two equivalents of dimethyl acetylenedicarboxylate in methanol. The transformation involves one C≡C triple bond cleavage and provides access to previously unexplored unsymmetrical functionalized 7,7′-biindolizines.
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Open AccessCommunication
Development of New Amide Derivatives of Betulinic Acid: Synthetic Approaches and Structural Characterization
by
Qinwei Xu, Yuhan Xie, Jin Qi, Zimo Ren, Carmine Coluccini and Paolo Coghi
Molbank 2025, 2025(4), M2072; https://doi.org/10.3390/M2072 (registering DOI) - 13 Oct 2025
Abstract
In this study, we report the synthesis of three new derivatives of betulinic acid, a pentacyclic triterpenoid known for its antitumor activity. These derivatives were synthesized via amide bond formation at the C-28 position using 3-[(Ethylimino)methylidene]amino-N,N-dimethylpropan-1-amine (EDC)/Hydroxybenzotriazole (HOBt) activation
[...] Read more.
In this study, we report the synthesis of three new derivatives of betulinic acid, a pentacyclic triterpenoid known for its antitumor activity. These derivatives were synthesized via amide bond formation at the C-28 position using 3-[(Ethylimino)methylidene]amino-N,N-dimethylpropan-1-amine (EDC)/Hydroxybenzotriazole (HOBt) activation and various amines as nucleophiles. The synthesized compounds were characterized by nuclear magnetic resonance (NMR) techniques, including proton (1H), carbon-13 (13C), COSY, HSQC, and DEPT, as well as ultraviolet–visible (UV-VIS) spectroscopy, Fourier-transform infrared (IR) and elemental analysis. This work highlights the potential of semi-synthetic modification of betulinic acid to enhance anticancer properties while addressing challenges in solubility and bioavailability. Further structural optimization and formulation studies are warranted to improve drug-like properties and therapeutic applicability.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
2,2,3,3-Tetrafluoropropyl 4-azido-2,3,5,6-Tetrafluorobenzoate
by
Sofia S. Kascheeva, Anastasiya V. Lastovka, Andrey S. Vinogradov, Tatyana V. Mezhenkova and Dmitriy A. Parkhomenko
Molbank 2025, 2025(4), M2070; https://doi.org/10.3390/M2070 - 10 Oct 2025
Abstract
Organic azides are traditionally used in organic synthesis to obtain a wide variety of chemical compounds. This prompted us to report the synthesis of a new polyfluorinated aryl azide, 2,2,3,3-tetrafluoropropyl 4-azido-2,3,5,6-tetrafluorobenzoate, which was obtained in two stages starting from pentafluorobenzoic acid.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Scheme 1
Open AccessCommunication
Crystal Structure of 3-(Anthracen-2′-yl)-ortho-carborane
by
Kyrill Yu. Suponitsky, Akim V. Shmal’ko, Sergey A. Anufriev and Igor B. Sivaev
Molbank 2025, 2025(4), M2071; https://doi.org/10.3390/M2071 - 10 Oct 2025
Abstract
Crystal molecular structure of 3-(anthracen-2′-yl)-ortho-carborane was determined by single crystal X-ray diffraction study at 100 K. The asymmetric cell unit contains two enantiomeric pairs of molecules, in one of which the intramolecular dihydrogen bond CH...HB is formed with the participation of
[...] Read more.
Crystal molecular structure of 3-(anthracen-2′-yl)-ortho-carborane was determined by single crystal X-ray diffraction study at 100 K. The asymmetric cell unit contains two enantiomeric pairs of molecules, in one of which the intramolecular dihydrogen bond CH...HB is formed with the participation of the C(1)H hydrogen of the anthracene substituent, and in the other with the participation of the C(3)H hydrogen. In all molecules, the polycyclic aromatic and carborane fragments are rotated relative to each other in such a way that the C-C bond of the ortho-carborane cage is approximately parallel to the plane of the aromatic substituent. According to quantum chemical calculations, the minimum energy corresponds to the formation of an intramolecular dihydrogen bond C(1)H...HB(4/7), whereas the C(3)H...HB(4/7) bond is formed rather as a result of intermolecular interactions in the crystal lattice.
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(This article belongs to the Section Structure Determination)
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Open AccessCommunication
Gas Phase Fragmentation of N,N-Ditosyl-2-aminodiphenylamine to Phenazine
by
M. John Plater and William T. A. Harrison
Molbank 2025, 2025(4), M2069; https://doi.org/10.3390/M2069 - 6 Oct 2025
Abstract
N,N-Ditosyl-2-aminodiphenylamine was prepared by the tosylation of 2-aminodiphenylamine with tosylchloride in dichloromethane. Unwanted isomers owing to the tosylation of the diarylamine were not formed. This compound was fully characterized by IR, UV/Vis, NMR, m/z, and mp, including an X-Ray
[...] Read more.
N,N-Ditosyl-2-aminodiphenylamine was prepared by the tosylation of 2-aminodiphenylamine with tosylchloride in dichloromethane. Unwanted isomers owing to the tosylation of the diarylamine were not formed. This compound was fully characterized by IR, UV/Vis, NMR, m/z, and mp, including an X-Ray single crystal structure determination. It was fragmented in an Atmospheric Solids Analysis Probe (ASAP) mass spectrometer showing a series of fragments down to phenazine.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
3-(4-Hydroxy-2,3,5-trimethylphenyl)-3-(4-hydroxyphenyl)isobenzofuran-1(3H)-one
by
Brian A. Chalmers, David B. Cordes, Aidan P. McKay, Iain L. J. Patterson, Russell J. Pearson, Nadiia Vladymyrova and Iain A. Smellie
Molbank 2025, 2025(4), M2067; https://doi.org/10.3390/M2067 - 1 Oct 2025
Abstract
3-(4-hydroxy-2,3,5-trimethylphenyl)-3-(4-hydroxyphenyl)isobenzofuran-1(3H)-one is a derivative of the well-known acid/base indicator, phenolphthalein. We report the synthesis and the molecular structure of the title compound as determined by single-crystal X-ray diffraction. 1H and 13C NMR spectroscopy, IR spectroscopy, and mass spectrometry data have been provided.
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(This article belongs to the Section Structure Determination)
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Open AccessCommunication
Synthesis and Characterization of Novel Pyridinium Salts of (E)-2-(Pyridin-4-ylmethylene)hydrazine-1-carboximidamide
by
Fatemeh Ataie Alani, Fatemeh Ahmadian, Alireza Houshdar Tehrani and Salimeh Amidi
Molbank 2025, 2025(4), M2068; https://doi.org/10.3390/M2068 - 1 Oct 2025
Abstract
We report the synthesis and characterization of the novel pyridinium salts from (E)-2-(pyridin-4-ylmethylene)hydrazine-1-carboximidamide. The pyridinium salts were obtained via the reaction of guanylhydrazone derived from pyridine-4-carbaldehyde with phenacyl bromides. Structural characterization was carried out using IR, 1H, and 13C
[...] Read more.
We report the synthesis and characterization of the novel pyridinium salts from (E)-2-(pyridin-4-ylmethylene)hydrazine-1-carboximidamide. The pyridinium salts were obtained via the reaction of guanylhydrazone derived from pyridine-4-carbaldehyde with phenacyl bromides. Structural characterization was carried out using IR, 1H, and 13C NMR spectroscopy and mass spectrometry.
Full article
(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
Dichloro[2,5-bis(diisopropylphosphorimidoyl-κN-(4,6-dimethylpyrimidine-κN))pyrrole-κN]yttrium(III)·toluene
by
Emily L. Trew, David Szucs and Paul G. Hayes
Molbank 2025, 2025(4), M2066; https://doi.org/10.3390/M2066 - 30 Sep 2025
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The compound dichloro[bis(diisopropylphosphorimidoyl-κN-(4,6-dimethylpyrimidine-κN))pyrrole-κN]yttrium(III) was synthesized from one equivalent of NaL [L = 2,5-[iPr2P=N(PymMe)]2NH(C4H2); PymMe = 4,6-dimethylpyrimidine] and YCl3(THF)3.5 and crystallized from
[...] Read more.
The compound dichloro[bis(diisopropylphosphorimidoyl-κN-(4,6-dimethylpyrimidine-κN))pyrrole-κN]yttrium(III) was synthesized from one equivalent of NaL [L = 2,5-[iPr2P=N(PymMe)]2NH(C4H2); PymMe = 4,6-dimethylpyrimidine] and YCl3(THF)3.5 and crystallized from toluene. X-ray quality crystals of LYCl2 were obtained with one toluene solvent molecule in the asymmetric unit. The geometry, bond lengths and angles were analyzed and found to contain similar parameters to comparable structures in the literature, and the product was further characterized by NMR spectroscopy. To the best of our knowledge, this is the first reported seven-coordinate Y(III) complex supported by a pentadentate ligand wherein all five donor atoms are nitrogen.
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Figure 1
Open AccessShort Note
(±)-2-(4-Isobutylphenyl)-N-(naphthalen-1-yl)propanamide
by
Diyana Dimitrova, Iliyan Ivanov, Stanimir Manolov and Dimitar Bojilov
Molbank 2025, 2025(4), M2065; https://doi.org/10.3390/M2065 - 30 Sep 2025
Abstract
We describe the synthesis of (±)-2-(4-isobutylphenyl)-N-(naphthalen-1-yl)propanamide, followed by comprehensive structural characterization. The compound was analyzed through melting point determination, 1H and 13C NMR spectroscopy, infrared spectroscopy, and mass spectrometry. The concordant results from these techniques provide clear evidence for
[...] Read more.
We describe the synthesis of (±)-2-(4-isobutylphenyl)-N-(naphthalen-1-yl)propanamide, followed by comprehensive structural characterization. The compound was analyzed through melting point determination, 1H and 13C NMR spectroscopy, infrared spectroscopy, and mass spectrometry. The concordant results from these techniques provide clear evidence for the successful preparation and structural confirmation of the target molecule.
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(This article belongs to the Section Structure Determination)
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Open AccessCommunication
A Tandem Photocycloaddition—Ring Expansion Strategy for the Synthesis of Fused [5.3.0] Triketone
by
Xin-Yi Hsiao, Chern Chuang and Gary Jing Chuang
Molbank 2025, 2025(3), M2064; https://doi.org/10.3390/M2064 - 22 Sep 2025
Abstract
A tandem synthetic sequence involving photo-induced intramolecular [2+2] cycloaddition followed by acid-promoted ring expansion was developed to access the novel bicyclic triketone framework. The process begins with the UV (254 nm) irradiation of cyclic vinylogous ester, affording a highly strained cyclobutane-fused diketone in
[...] Read more.
A tandem synthetic sequence involving photo-induced intramolecular [2+2] cycloaddition followed by acid-promoted ring expansion was developed to access the novel bicyclic triketone framework. The process begins with the UV (254 nm) irradiation of cyclic vinylogous ester, affording a highly strained cyclobutane-fused diketone in an 86% yield. This unique intermediate feature is of a fused four- and six-membered ring system with spatially compressed carbonyl groups. Upon acidic hydrolysis in aqueous MeCN, the strained system undergoes retro-aldol ring expansion, delivering [5.3.0] bicyclic triketones bearing a seven- and five-membered fused ring with three strategically oriented carbonyl units in a 75% yield. Structural elucidation was performed using NMR spectroscopy, UV-Vis, HRMS, and single-crystal X-ray crystallography. The method highlights a concise route for constructing a fused bicyclic triketone of relevance to synthetic and medicinal chemistry.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
1,1,1,3,3,3-Hexafluoropropan-2-yl 2,3,5,6-tetrafluoro-4-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)benzoate
by
Sofia S. Kascheeva, Anastasiya V. Lastovka, Andrey S. Vinogradov and Dmitriy A. Parkhomenko
Molbank 2025, 2025(3), M2063; https://doi.org/10.3390/M2063 - 18 Sep 2025
Abstract
Acyl chloride alcoholysis is a fundamental and typically high-yielding method for ester synthesis. However, competitive side reactions can occur when the acyl chloride possesses multiple electrophilic sites and the alcohol is a strong nucleophile. We report an example of this phenomenon: the reaction
[...] Read more.
Acyl chloride alcoholysis is a fundamental and typically high-yielding method for ester synthesis. However, competitive side reactions can occur when the acyl chloride possesses multiple electrophilic sites and the alcohol is a strong nucleophile. We report an example of this phenomenon: the reaction of pentafluorobenzoyl chloride with 1,1,1,3,3,3-hexafluoropropan-2-ol yields not only the expected ester but also a significant quantity of the 1,1,1,3,3,3-hexafluoropropan-2-yl 2,3,5,6-tetrafluoro-4-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)benzoate. The formation of the latter results from an effective nucleophilic aromatic substitution (SNAr) at the para-fluorine position of the pentafluorophenyl ring by the hexafluoroisopropoxide anion.
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(This article belongs to the Collection Molecules from Side Reactions)
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Open AccessShort Note
1-((Dimethyl(3-((2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyl)oxy)propyl)silyl)oxy)-3,5,7,9,11,13,15-heptakis((dimethylsilyl)oxy)-octasilsesquioxane
by
Analise C. H. Migliaccio, Andrea R. Kelley and Scott T. Iacono
Molbank 2025, 2025(3), M2062; https://doi.org/10.3390/M2062 - 17 Sep 2025
Abstract
The title compound was synthesized using Pt-catalyzed hydrosilylation of octasilane POSS and allyl 1H,1H-perfluorooctyl ether. The purity and structure were determined by NMR (1H, 13C, 19F, 29Si), and MALDI TOF-MS.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Scheme 1
Open AccessShort Note
(R)-4-Acetyl-10-(2-chloro-1,3-thiazol-4-yl)-5,11,13-trihydroxy-2,12-dimethyl-8-oxatricyclo[7.4.0.02,7]trideca-1(13),4,6,9,11-pentaen-3-one
by
Aleksandr S. Filimonov, Olga A. Luzina and Nariman F. Salakhutdinov
Molbank 2025, 2025(3), M2061; https://doi.org/10.3390/M2061 - 16 Sep 2025
Abstract
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A novel usnic acid derivative with 2-chlorothiazole substituent was obtained by a three-step synthesis from usnic acid. The structure of the product was proved by a set of physical methods, including 1H, 13C, HRMS, HSQC, HMBC and IR spectroscopy.
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Figure 1
Open AccessShort Note
Allyl Syringate
by
Naruedech Thimpa, Suriyaphong Poprom, Laksakarn Songpao and Nawasit Chotsaeng
Molbank 2025, 2025(3), M2060; https://doi.org/10.3390/M2060 - 15 Sep 2025
Abstract
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Syringic acid (1) is a naturally occurring compound with diverse biological activities. Structural modification of syringic acid often enhances its utility; however, the spectroscopic data for several derivatives remain unreported, and the procedures to obtain them can be synthetically challenging. In
[...] Read more.
Syringic acid (1) is a naturally occurring compound with diverse biological activities. Structural modification of syringic acid often enhances its utility; however, the spectroscopic data for several derivatives remain unreported, and the procedures to obtain them can be synthetically challenging. In this study, we report the allylation of syringic acid (1) to afford a novel derivative, allyl syringate (1c). The structure of this compound was confirmed by IR, NMR, and MS spectroscopy and compared with those of closely related derivatives (1a and 1b). These findings provide a useful foundation for further studies on the allylation of syringic acid and related phenolic acid derivatives.
Full article

Figure 1
Open AccessShort Note
4,11-Dimethyl-2,13-di-m-tolyltribenzo[b,e,g][1,4]dioxocine-7,8-dicarbonitrile
by
Dmitry Erzunov, Vyacheslav Baklagin, Vladimir Bukhalin, Igor Abramov, Kyrill Yu. Suponitsky and Arthur Vashurin
Molbank 2025, 2025(3), M2059; https://doi.org/10.3390/M2059 - 15 Sep 2025
Abstract
The synthesis and crystal structure of 4,11-dimethyl-2,13-di-m-tolyltribenzo[b,e,g][1,4]dioxocine-7,8-dicarbonitrile are reported. X-ray diffraction analysis reveals a rigid dioxocine core with m-tolyl substituents adopting torsional angles of 25–40°. The crystal packing is stabilized by C-H···N hydrogen bonds (2.6 Å) and π-π
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The synthesis and crystal structure of 4,11-dimethyl-2,13-di-m-tolyltribenzo[b,e,g][1,4]dioxocine-7,8-dicarbonitrile are reported. X-ray diffraction analysis reveals a rigid dioxocine core with m-tolyl substituents adopting torsional angles of 25–40°. The crystal packing is stabilized by C-H···N hydrogen bonds (2.6 Å) and π-π stacking interactions (3.4 Å) between dicarbonitrile groups, forming dimeric motifs. These structural insights provide a foundation for designing dioxocine-based functional materials.
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(This article belongs to the Section Structure Determination)
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Supplementary File 1 (ZIP, 2718 KB)
Supplementary File 2 (INCHI, 495 B)
Supplementary File 3 (MOL, 1 KB)
Supplementary File 4 (MOL, 2 KB)
Supplementary File 5 (MOL, 2 KB)
Supplementary File 6 (INCHI, 599 B)
Supplementary File 7 (MOL, 2 KB)
Supplementary File 8 (MOL, 2 KB)
Supplementary File 9 (INCHI, 710 B)
Supplementary File 10 (MOL, 2 KB)
Supplementary File 11 (MOL, 3 KB)
Supplementary File 12 (MOL, 3 KB)
Supplementary File 13 (INCHI, 844 B)
Supplementary File 14 (MOL, 3 KB)
Supplementary File 15 (INCHI, 864 B)
Supplementary File 16 (MOL, 3 KB)
Supplementary File 17 (MOL, 3 KB)
Supplementary File 18 (INCHI, 993 B)
Supplementary File 19 (MOL, 3 KB)
Supplementary File 20 (CIF, 1080 KB)
Open AccessCommunication
Synthesis of (Camphor-3-yl)acetic Acid-Derived Pyrazoles
by
Luka Ciber, Helena Brodnik, Nejc Petek, Franc Požgan, Jurij Svete, Bogdan Štefane and Uroš Grošelj
Molbank 2025, 2025(3), M2058; https://doi.org/10.3390/M2058 - 12 Sep 2025
Abstract
Two pyrazole derivatives were prepared in three steps from (camphor-3-yl)acetic acid. The pyrazole derivatives were fully characterized. The stereochemistry at the newly formed stereogenic center was confirmed by NOESY measurements and single crystal X-ray analysis.
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(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Open AccessShort Note
5-(2-Methylsulfanylethyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one
by
Petar Stanić, Marko V. Rodić and Biljana Šmit
Molbank 2025, 2025(3), M2057; https://doi.org/10.3390/M2057 - 4 Sep 2025
Abstract
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An amino acid-derived 2-thiohydantoin, 5-(2-methylsulfanylethyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one, obtained from l-methionine, was synthesized in a two-step reaction protocol with allyl isothiocyanate. The compound was obtained in an 82% yield and was fully structurally characterized by NMR and IR spectroscopy. The crystal structure, molecular packing, and
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An amino acid-derived 2-thiohydantoin, 5-(2-methylsulfanylethyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one, obtained from l-methionine, was synthesized in a two-step reaction protocol with allyl isothiocyanate. The compound was obtained in an 82% yield and was fully structurally characterized by NMR and IR spectroscopy. The crystal structure, molecular packing, and intermolecular interactions were characterized by X-ray diffraction analysis.
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Figure 1
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