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18 pages, 314 KiB

Open AccessArticle

The Economic Contributions of the Virginia Seafood Industry and the Effects of Virginia Seafood Products in Retail Stores and Restaurants in 2023

by Fernando H. Gonçalves, Jonathan van Senten and Michael H. Schwarz

Fishes 2025, 10(8), 373; https://doi.org/10.3390/fishes10080373 (registering DOI) - 2 Aug 2025

Abstract

Virginia’s coastal location and abundant marine resources make its seafood industry a vital contributor to the state’s economy, supporting both local communities and tourism. This study applied input–output models and updates the economic contributions of the Virginia seafood industry using 2023 data, building [...] Read more.

Virginia’s coastal location and abundant marine resources make its seafood industry a vital contributor to the state’s economy, supporting both local communities and tourism. This study applied input–output models and updates the economic contributions of the Virginia seafood industry using 2023 data, building on models developed for 2019 that capture both direct effects and broader economic ripple effects. In 2023, the industry generated USD 1.27 billion in total economic output and supported over 6500 jobs—including watermen, aquaculture farmers, processors, and distributors—resulting in USD 238.3 million in labor income. Contributions to state GDP totaled USD 976.7 million, and tax revenues exceeded USD 390.4 million. The study also evaluates the economic role of Virginia seafood products sold in retail stores and restaurants, based on secondary data sources. In 2023, these sectors generated USD 458 million in economic output, supported more than 3600 jobs, produced USD 136.7 million in labor income, and USD 280.8 million in value-added. Combined tax contributions surpassed USD 74 million. Importantly, the analysis results for the Virginia seafood products from retail and restaurant should not be summed to the seafood industry totals to avoid double-counting, as seafood products move as output from one sector as an input to another. These results provide evidence-based insights to guide decision-making, inform stakeholders, and support continued investment in Virginia’s seafood supply chain and related economic activities. Full article

(This article belongs to the Section Fishery Economics, Policy, and Management)

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25 pages, 28131 KiB

Open AccessArticle

Landslide Susceptibility Assessment in Ya’an Based on Coupling of GWR and TabNet

by Jiatian Li, Ruirui Wang, Wei Shi, Le Yang, Jiahao Wei, Fei Liu and Kaiwei Xiong

Remote Sens. 2025, 17(15), 2678; https://doi.org/10.3390/rs17152678 (registering DOI) - 2 Aug 2025

Abstract

Landslides are destructive geological hazards, making accurate landslide susceptibility assessment essential for disaster prevention and mitigation. However, existing studies often lack scientific rigor in negative sample construction and have unclear model applicability. This study focuses on Ya’an City, Sichuan Province, China, and proposes [...] Read more.

Landslides are destructive geological hazards, making accurate landslide susceptibility assessment essential for disaster prevention and mitigation. However, existing studies often lack scientific rigor in negative sample construction and have unclear model applicability. This study focuses on Ya’an City, Sichuan Province, China, and proposes an innovative approach to negative sample construction using Geographically Weighted Regression (GWR), which is then integrated with Tabular Network (TabNet), a deep learning architecture tailored to structured tabular data, to assess landslide susceptibility. The performance of TabNet is compared against Random Forest, Light Gradient Boosting Machine, deep neural networks, and Residual Networks. The experimental results indicate that (1) the GWR-based sampling strategy substantially improves model performance across all tested models; (2) TabNet trained using the GWR-based negative samples achieves superior performance over all other evaluated models, with an average AUC of 0.9828, exhibiting both high accuracy and interpretability; and (3) elevation, land cover, and annual Normalized Difference Vegetation Index are identified as dominant predictors through TabNet’s feature importance analysis. The results demonstrate that combining GWR and TabNet substantially enhances landslide susceptibility modeling by improving both accuracy and interpretability, establishing a more scientifically grounded approach to negative sample construction, and providing an interpretable, high-performing modeling framework for geological hazard risk assessment. Full article

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17 pages, 2085 KiB

Open AccessArticle

Identification Method of Weak Nodes in Distributed Photovoltaic Distribution Networks for Electric Vehicle Charging Station Planning

by Xiaoxing Lu, Xiaolong Xiao, Jian Liu, Ning Guo, Lu Liang and Jiacheng Li

World Electr. Veh. J. 2025, 16(8), 433; https://doi.org/10.3390/wevj16080433 (registering DOI) - 2 Aug 2025

Abstract

With the large-scale integration of high-penetration distributed photovoltaic (DPV) into distribution networks, its output volatility and reverse power flow characteristics are prone to causing voltage violations, necessitating the accurate identification of weak nodes to enhance operational reliability. This paper investigates the definition, quantification [...] Read more.

With the large-scale integration of high-penetration distributed photovoltaic (DPV) into distribution networks, its output volatility and reverse power flow characteristics are prone to causing voltage violations, necessitating the accurate identification of weak nodes to enhance operational reliability. This paper investigates the definition, quantification criteria, and multi-indicator comprehensive determination methods for weak nodes in distribution networks. A multi-criteria assessment method integrating voltage deviation rate, sensitivity analysis, and power margin has been proposed. This method quantifies the node disturbance resistance and comprehensively evaluates the vulnerability of voltage stability. Simulation validation based on the IEEE 33-node system demonstrates that the proposed method can effectively identify the distribution patterns of weak nodes under different penetration levels (20~80%) and varying numbers of DPV access points (single-point to multi-point distributed access scenarios). The study reveals the impact of increased penetration and dispersed access locations on the migration characteristics of weak nodes. The research findings provide a theoretical basis for the planning of distribution networks with high-penetration DPV, offering valuable insights for optimizing the siting of volatile loads such as electric vehicle (EV) charging stations while considering both grid safety and the demand for distributed energy accommodation. Full article

(This article belongs to the Special Issue Fast-Charging Station for Electric Vehicles: Challenges and Issues)

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38 pages, 6505 KiB

Open AccessReview

Trends in Oil Spill Modeling: A Review of the Literature

by Rodrigo N. Vasconcelos, André T. Cunha Lima, Carlos A. D. Lentini, José Garcia V. Miranda, Luís F. F. de Mendonça, Diego P. Costa, Soltan G. Duverger and Elaine C. B. Cambui

Water 2025, 17(15), 2300; https://doi.org/10.3390/w17152300 (registering DOI) - 2 Aug 2025

Abstract

Oil spill simulation models are essential for predicting the oil spill behavior and movement in marine environments. In this study, we comprehensively reviewed a large and diverse body of peer-reviewed literature obtained from Scopus and Web of Science. Our initial analysis phase focused [...] Read more.

Oil spill simulation models are essential for predicting the oil spill behavior and movement in marine environments. In this study, we comprehensively reviewed a large and diverse body of peer-reviewed literature obtained from Scopus and Web of Science. Our initial analysis phase focused on examining trends in scientific publications, utilizing the complete dataset derived after systematic screening and database integration. In the second phase, we applied elements of a systematic review to identify and evaluate the most influential contributions in the scientific field of oil spill simulations. Our analysis revealed a steady and accelerating growth of research activity over the past five decades, with a particularly notable expansion in the last two. The field has also experienced a marked increase in collaborative practices, including a rise in international co-authorship and multi-authored contributions, reflecting a more global and interdisciplinary research landscape. We cataloged the key modeling frameworks that have shaped the field from established systems such as OSCAR, OIL-MAP/SIMAP, and GNOME to emerging hybrid and Lagrangian approaches. Hydrodynamic models were consistently central, often integrated with biogeochemical, wave, atmospheric, and oil-spill-specific modules. Environmental variables such as wind, ocean currents, and temperature were frequently used to drive model behavior. Geographically, research has concentrated on ecologically and economically sensitive coastal and marine regions. We conclude that future progress will rely on the real-time integration of high-resolution environmental data streams, the development of machine-learning-based surrogate models to accelerate computations, and the incorporation of advanced biodegradation and weathering mechanisms supported by experimental data. These advancements are expected to enhance the accuracy, responsiveness, and operational value of oil spill modeling tools, supporting environmental monitoring and emergency response. Full article

(This article belongs to the Special Issue Advanced Remote Sensing for Coastal System Monitoring and Management)

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11 pages, 782 KiB

Open AccessArticle

Exploring the Association Between Platelet Count, the Systemic Immune Inflammation Index, and Fracture Risk in Postmenopausal Women with Osteoporosis: A Cross-Sectional Study

by Cecilia Oliveri, Anastasia Xourafa, Rita Maria Agostino, Valentina Corigliano, Antonino Botindari, Agostino Gaudio, Nunziata Morabito, Alessandro Allegra and Antonino Catalano

J. Clin. Med. 2025, 14(15), 5453; https://doi.org/10.3390/jcm14155453 (registering DOI) - 2 Aug 2025

Abstract

Background/Objectives: Platelets play a role in bone metabolism and fracture healing. This study aimed to investigate the association between platelet indices and the derived systemic immune inflammation index (SII) with fracture risk in postmenopausal women. Methods: Platelet count, mean platelet volume, platelet distribution [...] Read more.

Background/Objectives: Platelets play a role in bone metabolism and fracture healing. This study aimed to investigate the association between platelet indices and the derived systemic immune inflammation index (SII) with fracture risk in postmenopausal women. Methods: Platelet count, mean platelet volume, platelet distribution width (PDW), platelet crit, percentage of large platelets (P-LCR), platelet–lymphocyte ratio, and the SII, calculated as (NxP)/L, where N, P, and L represented neutrophils, platelets and lymphocytes counts, respectively, were evaluated. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. Results: A total of 124 women (mean age 68.4 ± 9 years) were stratified into two groups based on the median platelet count; the “lower platelet count group” (n = 58) had a count of 200,000 (174,000 to 226,000), while the “higher platelet count group” (n = 66) had a count of 281,500 (256,500 to 308,500). The higher platelet count group showed a higher hip fracture risk (7.4 vs. 4.5%, p = 0.08) and lower lumbar spine BMD (0.773 vs. 0.83 gr/cm², p = 0.03). By dividing the participants into two groups with higher SSI (950,848.6 ± 746,097.99) (n = 61) and lower SII (355,751.2 ± 88,662.6) (n = 63), the group with the higher SII showed the higher hip fracture risk (7.4 vs. 3.6%, p = 0.01). Univariate regression analysis revealed correlations between chronological age and PDW (r = 0.188, p = 0.047), and P-LCR (r = 0.208, p = 0.03), as well as associations between vitamin D status and P-LCR (r = −0.301, p = 0.034), and between SII and hip fracture risk (r = 0.12, p = 0.007). Conclusions: Platelet count and SII were associated with fracture risk in postmenopausal women undergoing osteoporosis assessment. Given their reproducibility and cost-effectiveness, these markers warrant further investigation in future prospective studies focused on bone fragility. Full article

(This article belongs to the Special Issue Diagnosis, Treatment, Prevention and Rehabilitation in Osteoporosis)

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17 pages, 516 KiB

Open AccessArticle

Incidence and Predictive Factors of Acute Kidney Injury After Major Hepatectomy: Implications for Patient Management in Era of Enhanced Recovery After Surgery (ERAS) Protocols

by Henri Mingaud, Jean Manuel de Guibert, Jonathan Garnier, Laurent Chow-Chine, Frederic Gonzalez, Magali Bisbal, Jurgita Alisauskaite, Antoine Sannini, Marc Léone, Marie Tezier, Maxime Tourret, Sylvie Cambon, Jacques Ewald, Camille Pouliquen, Lam Nguyen Duong, Florence Ettori, Olivier Turrini, Marion Faucher and Djamel Mokart

J. Clin. Med. 2025, 14(15), 5452; https://doi.org/10.3390/jcm14155452 (registering DOI) - 2 Aug 2025

Abstract

Background: Acute kidney injury (AKI) frequently occurs following major liver resection, adversely affecting both short- and long-term outcomes. This study aimed to determine the incidence of AKI post-hepatectomy and identify relevant pre- and intraoperative risk factors. Our secondary objectives were to develop [...] Read more.

Background: Acute kidney injury (AKI) frequently occurs following major liver resection, adversely affecting both short- and long-term outcomes. This study aimed to determine the incidence of AKI post-hepatectomy and identify relevant pre- and intraoperative risk factors. Our secondary objectives were to develop a predictive score for postoperative AKI and assess the associations between AKI, chronic kidney disease (CKD), and 1-year mortality. Methods: This was a retrospective study in a cancer referral center in Marseille, France, from 2018 to 2022. Results: Among 169 patients, 55 (32.5%) experienced AKI. Multivariate analysis revealed several independent risk factors for postoperative AKI, including age, body mass index, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, time to liver resection, intraoperative shock, and bile duct reconstruction. Neoadjuvant chemotherapy was protective. The AKIMEBO score was developed, with a threshold of ≥15.6, demonstrating a sensitivity of 89.5%, specificity of 76.4%, positive predictive value of 61.8%, and negative predictive value of 94.4%. AKI was associated with increased postoperative morbidity and one-year mortality following major hepatectomy. Conclusion: AKI is a common complication post-hepatectomy. Factors such as time to liver resection and intraoperative shock management present potential clinical intervention points. The AKIMEBO score can provide a valuable tool for postoperative risk stratification. Full article

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

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22 pages, 5283 KiB

Open AccessArticle

Transcriptome Analysis Reveals Candidate Pathways and Genes Involved in Wheat (Triticum aestivum L.) Response to Zinc Deficiency

by Shoujing Zhu, Shiqi Zhang, Wen Wang, Nengbing Hu and Wenjuan Shi

Biology 2025, 14(8), 985; https://doi.org/10.3390/biology14080985 (registering DOI) - 2 Aug 2025

Abstract

Zinc (Zn) deficiency poses a major global health challenge, and wheat grains generally contain low Zn concentrations. In this study, the wheat cultivar ‘Zhongmai 175’ was identified as zinc-efficient. Hydroponic experiments demonstrated that Zn deficiency induced the secretion of oxalic acid and malic [...] Read more.

Zinc (Zn) deficiency poses a major global health challenge, and wheat grains generally contain low Zn concentrations. In this study, the wheat cultivar ‘Zhongmai 175’ was identified as zinc-efficient. Hydroponic experiments demonstrated that Zn deficiency induced the secretion of oxalic acid and malic acid in root exudates and significantly increased total root length in ‘Zhongmai 175’. To elucidate the underlying regulatory mechanisms, transcriptome profiling via RNA sequencing was conducted under Zn-deficient conditions. A total of 2287 and 1935 differentially expressed genes (DEGs) were identified in roots and shoots, respectively. Gene Ontology enrichment analysis revealed that these DEGs were primarily associated with Zn ion transport, homeostasis, transmembrane transport, and hormone signaling. Key DEGs belonged to gene families including VIT, NAS, DMAS, ZIP, tDT, HMA, and NAAT. KEGG pathway analysis indicated that phenylpropanoid biosynthesis, particularly lignin synthesis genes, was significantly downregulated in Zn-deficient roots. In shoots, cysteine and methionine metabolism, along with plant hormone signal transduction, were the most enriched pathways. Notably, most DEGs in shoots were associated with the biosynthesis of phytosiderophores (MAs, NA) and ethylene. Overall, genes involved in Zn ion transport, phytosiderophore biosynthesis, dicarboxylate transport, and ethylene biosynthesis appear to play central roles in wheat’s adaptive response to Zn deficiency. These findings provide a valuable foundation for understanding the molecular basis of Zn efficiency in wheat and for breeding Zn-enriched varieties. Full article

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16 pages, 2901 KiB

Open AccessArticle

Unveiling the Genetic Landscape of Canine Papillomavirus in the Brazilian Amazon

by Jeneffer Caroline de Macêdo Sousa, André de Medeiros Costa Lins, Fernanda dos Anjos Souza, Higor Ortiz Manoel, Cleyton Silva de Araújo, Lorena Yanet Cáceres Tomaya, Paulo Henrique Gilio Gasparotto, Vyctoria Malayhka de Abreu Góes Pereira, Acácio Duarte Pacheco, Fernando Rosado Spilki, Mariana Soares da Silva, Felipe Masiero Salvarani, Cláudio Wageck Canal, Flavio Roberto Chaves da Silva and Cíntia Daudt

Microorganisms 2025, 13(8), 1811; https://doi.org/10.3390/microorganisms13081811 (registering DOI) - 2 Aug 2025

Abstract

Papillomaviruses (PVs) are double-stranded DNA viruses known to induce a variety of epithelial lesions in dogs, ranging from benign hyperplasia to malignancies. In regions of rich biodiversity such as the Western Amazon, data on the circulation and genetic composition of canine papillomaviruses (CPVs) [...] Read more.

Papillomaviruses (PVs) are double-stranded DNA viruses known to induce a variety of epithelial lesions in dogs, ranging from benign hyperplasia to malignancies. In regions of rich biodiversity such as the Western Amazon, data on the circulation and genetic composition of canine papillomaviruses (CPVs) remain scarce. This study investigated CPV types present in oral and cutaneous papillomatous lesions in domiciled dogs from Acre and Rondônia States, Brazil. Sixty-one dogs with macroscopically consistent lesions were clinically evaluated, and tissue samples were collected for histopathological examination and PCR targeting the L1 gene. Among these, 37% were histologically diagnosed as squamous papillomas or fibropapillomas, and 49.2% (30/61) tested positive for papillomavirus DNA. Sequencing of the L1 gene revealed that most positive samples belonged to CPV1 (Lambdapapillomavirus 2), while one case was identified as CPV8 (Chipapillomavirus 3). Complete genomes of three CPV1 strains were obtained via high-throughput sequencing and showed high identity with CPV1 strains from other Brazilian regions. Phylogenetic analysis confirmed close genetic relationships among isolates across distinct geographic areas. These findings demonstrate the circulation of genetically conserved CPVs in the Amazon and reinforce the value of molecular and histopathological approaches for the accurate diagnosis and surveillance of viral diseases in domestic dogs, especially in ecologically complex regions. Full article

(This article belongs to the Topic Advances in Infectious and Parasitic Diseases of Animals)

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24 pages, 4301 KiB

Open AccessArticle

Estimation of the Kinetic Coefficient of Friction of Asphalt Pavements Using the Top Topography Surface Roughness Power Spectrum

by Bo Sun, Haoyuan Luo, Yibo Rong and Yanqin Yang

Materials 2025, 18(15), 3643; https://doi.org/10.3390/ma18153643 (registering DOI) - 2 Aug 2025

Abstract

This study proposes a method for estimating the kinetic coefficient of friction (COF) for asphalt pavements by improving and applying Persson’s friction theory. The method utilizes the power spectral density (PSD) of the top surface topography instead of the full PSD to better [...] Read more.

This study proposes a method for estimating the kinetic coefficient of friction (COF) for asphalt pavements by improving and applying Persson’s friction theory. The method utilizes the power spectral density (PSD) of the top surface topography instead of the full PSD to better reflect the actual contact conditions. This approach avoids including deeper roughness components that do not contribute to real rubber–pavement contact due to surface skewness. The key aspect of the method is determining an appropriate cutting plane to isolate the top surface. Four cutting strategies were evaluated. Results show that the cutting plane defined at 0.5 times the root mean square (RMS) height exhibits the highest robustness across all pavement types, with the estimated COF closely matching the measured values for all four tested surfaces. This study presents an improved method for estimating the kinetic coefficient of friction (COF) of asphalt pavements by employing the power spectral density (PSD) of the top surface roughness, rather than the total surface profile. This refinement is based on Persson’s friction theory and aims to exclude the influence of deep surface irregularities that do not make actual contact with the rubber interface. The core of the method lies in defining an appropriate cutting plane to isolate the topographical features that contribute most to frictional interactions. Four cutting strategies were investigated. Among them, the cutting plane positioned at 0.5 times the root mean square (RMS) height demonstrated the best overall applicability. COF estimates derived from this method showed strong consistency with experimentally measured values across all four tested asphalt pavement surfaces, indicating its robustness and practical potential. Full article

(This article belongs to the Section Construction and Building Materials)

30 pages, 8223 KiB

Open AccessArticle

Optimal Time–Jerk Trajectory Planning for Manipulators Based on a Constrained Multi-Objective Dream Optimization Algorithm

by Zhijun Wu, Fang Wang and Tingting Bao

Machines 2025, 13(8), 682; https://doi.org/10.3390/machines13080682 (registering DOI) - 2 Aug 2025

Abstract

A multi-objective optimal trajectory planning method is proposed for manipulators in this paper to enhance motion efficiency and to reduce component wear while ensuring motion smoothness. The trajectory is initially interpolated in the joint space by using quintic non-uniform B-splines with virtual points, [...] Read more.

A multi-objective optimal trajectory planning method is proposed for manipulators in this paper to enhance motion efficiency and to reduce component wear while ensuring motion smoothness. The trajectory is initially interpolated in the joint space by using quintic non-uniform B-splines with virtual points, achieving the C⁴ continuity of joint motion and satisfying dynamic, kinematic, geometric, synchronization, and boundary constraints. The interpolation reformulates the trajectory planning problem into an optimization problem, where the time intervals between desired adjacent waypoints serve as variables. Travelling time and the integral of the squared jerk along the entire trajectories comprise the multi-objective functions. A constrained multi-objective dream optimization algorithm is designed to solve the time–jerk optimal trajectory planning problem and generate Pareto solutions for optimized trajectories. Simulations conducted on 6-DOF manipulators validate the effectiveness and superiority of the proposed method in comparison with existing typical trajectory planning methods. Full article

(This article belongs to the Special Issue Cutting-Edge Automation in Robotic Machining)

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21 pages, 672 KiB

Open AccessSystematic Review

Assessing and Understanding Educators’ Experiences of Synchronous Hybrid Learning in Universities: A Systematic Review

by Hannah Clare Wood, Michael Detyna and Eleanor Jane Dommett

Educ. Sci. 2025, 15(8), 987; https://doi.org/10.3390/educsci15080987 (registering DOI) - 2 Aug 2025

Abstract

The rise in online learning, accelerated by the COVID-19 pandemic, has led to greater use of synchronous hybrid learning (SHL) in higher education. SHL allows simultaneous teaching of in-person and online learners through videoconferencing tools. Previous studies have identified various benefits (e.g., flexibility) [...] Read more.

The rise in online learning, accelerated by the COVID-19 pandemic, has led to greater use of synchronous hybrid learning (SHL) in higher education. SHL allows simultaneous teaching of in-person and online learners through videoconferencing tools. Previous studies have identified various benefits (e.g., flexibility) and challenges (e.g., student engagement) to SHL. Whilst systematic reviews have emerged on this topic, few studies have considered the experiences of staff. The aim of this review was threefold: (i) to better understand how staff experiences and perceptions are assessed, (ii) to understand staff experiences in terms of the benefits and challenges of SHL and (iii) to identify recommendations for effective teaching and learning using SHL. In line with the PRISMA guidance, we conducted a systematic review across four databases, identifying 14 studies for inclusion. Studies were conducted in nine different countries and covered a range of academic disciplines. Most studies adopted qualitative methods, with small sample sizes. Measures used were typically novel and unvalidated. Four themes were identified relating to (i) technology, (ii) redesigning teaching and learning, (iii) student engagement and (iv) staff workload. In terms of recommendations, ensuring adequate staff training and ongoing classroom support were considered essential. Additionally, active and collaborative learning were considered important to address issues with interactivity. Whilst these findings largely aligned with previous work, this review also identified limited reporting in research in this area, and future studies are needed to address this. Full article

(This article belongs to the Section Higher Education)

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31 pages, 9769 KiB

Open AccessReview

Recent Advances of Hybrid Nanogenerators for Sustainable Ocean Energy Harvesting: Performance, Applications, and Challenges

by Enrique Delgado-Alvarado, Enrique A. Morales-Gonzalez, José Amir Gonzalez-Calderon, Ma. Cristina Irma Peréz-Peréz, Jesús Delgado-Maciel, Mariana G. Peña-Juarez, José Hernandez-Hernandez, Ernesto A. Elvira-Hernandez, Maximo A. Figueroa-Navarro and Agustin L. Herrera-May

Technologies 2025, 13(8), 336; https://doi.org/10.3390/technologies13080336 (registering DOI) - 2 Aug 2025

Abstract

Ocean energy is an abundant, eco-friendly, and renewable energy resource that is useful for powering sensor networks connected to the maritime Internet of Things (MIoT). These sensor networks can be used to measure different marine environmental parameters that affect ocean infrastructure integrity and [...] Read more.

Ocean energy is an abundant, eco-friendly, and renewable energy resource that is useful for powering sensor networks connected to the maritime Internet of Things (MIoT). These sensor networks can be used to measure different marine environmental parameters that affect ocean infrastructure integrity and harm marine ecosystems. This ocean energy can be harnessed through hybrid nanogenerators that combine triboelectric nanogenerators, electromagnetic generators, piezoelectric nanogenerators, and pyroelectric generators. These nanogenerators have advantages such as high-power density, robust design, easy operating principle, and cost-effective fabrication. However, the performance of these nanogenerators can be affected by the wear of their main components, reduction of wave frequency and amplitude, extreme corrosion, and sea storms. To address these challenges, future research on hybrid nanogenerators must improve their mechanical strength, including materials and packages with anti-corrosion coatings. Herein, we present recent advances in the performance of different hybrid nanogenerators to harvest ocean energy, including various transduction mechanisms. Furthermore, this review reports potential applications of hybrid nanogenerators to power devices in marine infrastructure or serve as self-powered MIoT monitoring sensor networks. This review discusses key challenges that must be addressed to achieve the commercial success of these nanogenerators, regarding design strategies with advanced simulation models or digital twins. Also, these strategies must incorporate new materials that improve the performance, reliability, and integration of future nanogenerator array systems. Thus, optimized hybrid nanogenerators can represent a promising technology for ocean energy harvesting with application in the maritime industry. Full article

(This article belongs to the Special Issue Technological Advances in Science, Medicine, and Engineering 2024)

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19 pages, 443 KiB

Open AccessArticle

Effects of a Flipped Classroom College Business Course on Students’ Pre-Class Preparation, In-Class Participation, Learning, and Skills Development

by Gordon Wang

Adm. Sci. 2025, 15(8), 301; https://doi.org/10.3390/admsci15080301 (registering DOI) - 2 Aug 2025

Abstract

As an example of pedagogical approaches that blend online and face-to-face instruction, the flipped classroom model has seen exponential growth in business schools. To explore its effectiveness, expectancy-value theory and cognitive load theory were employed to develop a framework linking students’ perceived usefulness [...] Read more.

As an example of pedagogical approaches that blend online and face-to-face instruction, the flipped classroom model has seen exponential growth in business schools. To explore its effectiveness, expectancy-value theory and cognitive load theory were employed to develop a framework linking students’ perceived usefulness of the online and in-person content to their pre-class preparation, class participation, perceived learning, and skills development. A preliminary test of this framework was conducted using a flipped Organizational Behavior course within a business diploma program at a publicly funded Canadian college. The perceived usefulness of the online component was positively associated with students’ pre-class preparation, which, in turn, was positively related to both their perceived learning and skills development. Implications for practice and directions for future research are discussed. Full article

(This article belongs to the Section Organizational Behavior)

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22 pages, 3994 KiB

Open AccessArticle

Analysis of Foaming Properties, Foam Stability, and Basic Physicochemical and Application Parameters of Bio-Based Car Shampoos

by Bartosz Woźniak, Agata Wawrzyńczak and Izabela Nowak

Coatings 2025, 15(8), 907; https://doi.org/10.3390/coatings15080907 (registering DOI) - 2 Aug 2025

Abstract

Environmental protection has become one of the key challenges of our time. This has led to an increase in pro-environmental activities in the field of cosmetics and household chemicals, where manufacturers are increasingly trying to meet the expectations of consumers who are aware [...] Read more.

Environmental protection has become one of the key challenges of our time. This has led to an increase in pro-environmental activities in the field of cosmetics and household chemicals, where manufacturers are increasingly trying to meet the expectations of consumers who are aware of the potential risks associated with the production of cosmetics and household chemistry products. This is one of the most important challenges of today’s industry, given that some of the raw materials still commonly used, such as surfactants, may be toxic to aquatic organisms. Many companies are choosing to use natural raw materials that have satisfactory performance properties but are also environmentally friendly. In addition, modern products are also characterized by reduced consumption of water, resources, and energy in production processes. These measures reduce the carbon footprint and reduce the amount of plastic packaging required. In the present study, seven formulations of environmentally friendly car shampoo concentrates were developed, based entirely on mixtures of bio-based surfactants. The developed formulations were tested for application on the car body surface, allowing the selection of the two best products. For these selected formulations, an in-depth physicochemical analysis was carried out, including pH, density, and viscosity measurements. Comparison of the results with commercial products available on the market was also performed. Additionally, using the multiple light scattering method, the foamability and foam stability were determined for the car shampoos developed. The results obtained indicate the very high application potential of the products under study, which combine high performance and environmental concerns. Full article

(This article belongs to the Section Environmental Aspects in Colloid and Interface Science)

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56 pages, 1035 KiB

Open AccessReview

Trace Elements—Role in Joint Function and Impact on Joint Diseases

by Łukasz Bryliński, Katarzyna Brylińska, Filip Woliński, Jolanta Sado, Miłosz Smyk, Olga Komar, Robert Karpiński, Marcin Prządka and Jacek Baj

Int. J. Mol. Sci. 2025, 26(15), 7493; https://doi.org/10.3390/ijms26157493 (registering DOI) - 2 Aug 2025

Abstract

Proper joint function has a significant impact on people’s quality of life. Joints are the point of connection between two or more bones and consist of at least three elements: joint surfaces, the joint capsule, and the joint cavity. Joint diseases are a [...] Read more.

Proper joint function has a significant impact on people’s quality of life. Joints are the point of connection between two or more bones and consist of at least three elements: joint surfaces, the joint capsule, and the joint cavity. Joint diseases are a serious social problem. Risk factors for the development of these diseases include overweight and obesity, gender, and intestinal microbiome disorders. Another factor that is considered to influence joint diseases is trace elements. Under normal conditions, elements such as iron (Fe), copper (Cu), cobalt (Co), iodine (I), manganese (Mn), zinc (Zn), silver (Ag), cadmium (Cd), mercury (Hg), lead (Pb), nickel (Ni) selenium (Se), boron (B), and silicon (Si) are part of enzymes involved in reactions that determine the proper functioning of cells, regulate redox metabolism, and determine the maturation of cells that build joint components. However, when the normal concentration of the above-mentioned elements is disturbed and toxic elements are present, dangerous joint diseases can develop. In this article, we focus on the role of trace elements in joint function. We describe the molecular mechanisms that explain their interaction with chondrocytes, osteocytes, osteoblasts, osteoclasts, and synoviocytes, as well as their proliferation, apoptosis, and extracellular matrix synthesis. We also focus on the role of these trace elements in the pathogenesis of joint diseases: rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE). We describe the roles of increased or decreased concentrations of individual elements in the pathogenesis and development of joint diseases and their impact on inflammation and disease progression, referring to molecular mechanisms. We also discuss their potential application in the treatment of joint diseases. Full article

(This article belongs to the Special Issue Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach)

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17 pages, 745 KiB

Open AccessFeature PaperArticle

The Relationship Between Parental Phubbing and Preschoolers’ Behavioral Problems: The Mediation Role of Mindful Attention Awareness

by Antonio Puligheddu, Annamaria Porru, Andrea Spano, Stefania Cataudella, Maria Lidia Mascia, Dolores Rollo, Cristina Cabras, Maria Pietronilla Penna and Daniela Lucangeli

Children 2025, 12(8), 1022; https://doi.org/10.3390/children12081022 (registering DOI) - 2 Aug 2025

Abstract

Phubbing, a relatively new phenomenon in the field of digital risks, refers to the act of ignoring someone in favor of focusing on a smartphone during face-to-face interactions. Parental phubbing, a specific form of this behavior, is a prevalent negative parenting practice that [...] Read more.

Phubbing, a relatively new phenomenon in the field of digital risks, refers to the act of ignoring someone in favor of focusing on a smartphone during face-to-face interactions. Parental phubbing, a specific form of this behavior, is a prevalent negative parenting practice that can affect parent–child relationships and child development. However, the impact of parental phubbing on the emotional and behavioral development of preschool children remains unclear. This study aims to explore the relationship between parental phubbing and preschoolers’ behavioral problems, as well as test whether parents’ mindful attention awareness (MAA) acts as a mediator between them. Method: A questionnaire was administered to 138 Italian parents (mean age = 38.5, SD = 6.2) of 138 kindergarten preschoolers (mean age = 3.9, SD = 1.03). Questionnaires included the Generic Scale of Phubbing (GSP), the Mindful Attention Awareness Scale (MAAS), and the Strengths and Difficulties Questionnaire (SDQ). Results: Analyses revealed a significant negative correlation between the MAAS and SDQ total scores, a positive correlation between the GSP total score and the SDQ total score, and a negative correlation between the GSP total score and the MAAS total score. The mediation analysis did not show a direct effect of GSP on SDQ, suggesting that parental phubbing did not directly predict children’s behavioral difficulties. Nevertheless, the indirect effect measured by bootstrapping was significant, indicating that parental MAA fully mediated the relationship between parental phubbing and preschoolers’ problematic behaviors. Conclusions: Although further research is needed, parental mindfulness may influence phubbing behaviors in parents providing valuable insights for early interventions aimed at reducing problem behaviors in young children. Full article

(This article belongs to the Section Pediatric Mental Health)

18 pages, 4468 KiB

Open AccessArticle

Proteomic and Functional Analysis Reveals Temperature-Driven Immune Evasion Strategies of Streptococcus iniae in Yellowfin Seabream (Acanthopagrus latus)

by Yanjian Yang, Guanrong Zhang, Ruilong Xu, Yiyang Deng, Zequan Mo, Yanwei Li and Xueming Dan

Biology 2025, 14(8), 986; https://doi.org/10.3390/biology14080986 (registering DOI) - 2 Aug 2025

Abstract

Streptococcus iniae (S. iniae) is a globally significant aquatic pathogen responsible for severe economic losses in aquaculture. While the S. iniae infection often exhibits distinct seasonal patterns strongly correlated with water temperature, there is limited knowledge regarding the temperature-dependent immune evasion [...] Read more.

Streptococcus iniae (S. iniae) is a globally significant aquatic pathogen responsible for severe economic losses in aquaculture. While the S. iniae infection often exhibits distinct seasonal patterns strongly correlated with water temperature, there is limited knowledge regarding the temperature-dependent immune evasion strategies of S. iniae. Our results demonstrated a striking temperature-dependent virulence phenotype, with significantly higher A. latus mortality rates observed at high temperature (HT, 33 °C) compared to low temperature (LT, 23 °C). Proteomic analysis revealed temperature-dependent upregulation of key virulence factors, including streptolysin S-related proteins (SagG, SagH), antioxidant-related proteins (SodA), and multiple capsular polysaccharide (cps) synthesis proteins (cpsD, cpsH, cpsL, cpsY). Flow cytometry analysis showed that HT infection significantly reduced the percentage of lymphocyte and myeloid cell populations in the head kidney leukocytes of A. latus, which was associated with elevated caspase-3/7 expression and increased apoptosis. In addition, HT infection significantly inhibited the release of reactive oxygen species (ROS) but not nitric oxide (NO) production. Using S. iniae cps-deficient mutant, Δcps, we demonstrated that the cps is essential for temperature-dependent phagocytosis resistance in S. iniae, as phagocytic activity against Δcps remained unchanged across temperatures, while NS-1 showed significantly reduced uptake at HT. These findings provide new insights into the immune evasion of S. iniae under thermal regulation, deepening our understanding of the thermal adaptation of aquatic bacterial pathogens. Full article

(This article belongs to the Special Issue Aquatic Economic Animal Breeding and Healthy Farming)

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16 pages, 2227 KiB

Open AccessArticle

Physiological and Transcriptomic Mechanisms Underlying Vitamin C-Mediated Cold Stress Tolerance in Grafted Cucumber

by Panpan Yu, Junkai Wang, Xuyang Zhang, Zhenglong Weng, Kaisen Huo, Qiuxia Yi, Chenxi Wu, Sunjeet Kumar, Hao Gao, Lin Fu, Yanli Chen and Guopeng Zhu

Plants 2025, 14(15), 2398; https://doi.org/10.3390/plants14152398 (registering DOI) - 2 Aug 2025

Abstract

Cucumbers (Cucumis sativus L.) are highly sensitive to cold, but grafting onto cold-tolerant rootstocks can enhance their low-temperature resilience. This study investigates the physiological and molecular mechanisms by which exogenous vitamin C (Vc) mitigates cold stress in grafted cucumber seedlings. Using cucumber [...] Read more.

Cucumbers (Cucumis sativus L.) are highly sensitive to cold, but grafting onto cold-tolerant rootstocks can enhance their low-temperature resilience. This study investigates the physiological and molecular mechanisms by which exogenous vitamin C (Vc) mitigates cold stress in grafted cucumber seedlings. Using cucumber ‘Chiyu 505’ as the scion and pumpkin ‘Chuangfan No.1’ as the rootstock, seedlings were grafted using the whip grafting method. In the third true leaf expansion stage, seedlings were foliar sprayed with Vc at concentrations of 50, 100, 150, and 200 mg L⁻¹. Three days after initial spraying, seedlings were subjected to cold stress (8 °C) for 3 days, with continued spraying. After that, morphological and physiological parameters were assessed. Results showed that 150 mg L⁻¹ Vc treatment was most impactive, significantly reducing the cold damage index while increasing the root-to-shoot ratio, root vitality, chlorophyll content, and activities of antioxidant enzymes (SOD, POD, CAT). Moreover, this treatment enhanced levels of soluble sugars, soluble proteins, and proline compared to control. However, 200 mg L⁻¹ treatment elevated malondialdehyde (MDA) content, indicating potential oxidative stress. For transcriptomic analysis, leaves from the 150 mg L⁻¹ Vc and CK treatments were sampled at 0, 1, 2, and 3 days of cold stress. Differential gene expression revealed that genes associated with photosynthesis (LHCA1), stress signal transduction (MYC2-1, MYC2-2, WRKY22, WRKY2), and antioxidant defense (SOD-1, SOD-2) were initially up-regulated and subsequently down-regulated, as validated by qRT-PCR. Overall, we found that the application of 150 mg L⁻¹ Vc enhanced cold tolerance in grafted cucumber seedlings by modulating gene expression networks related to photosynthesis, stress response, and the antioxidant defense system. This study provides a way for developing Vc biostimulants to enhance cold tolerance in grafted cucumbers, improving sustainable cultivation in low-temperature regions. Full article

(This article belongs to the Section Plant Response to Abiotic Stress and Climate Change)

23 pages, 2091 KiB

Open AccessArticle

Exploring the Impact of Bioactive Compounds Found in Extra Virgin Olive Oil on NRF2 Modulation in Alzheimer’s Disease

by Marilena M. Bourdakou, Eleni M. Loizidou and George M. Spyrou

Antioxidants 2025, 14(8), 952; https://doi.org/10.3390/antiox14080952 (registering DOI) - 2 Aug 2025

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier dysfunction, oxidative stress (OS), and neuroinflammation. Current treatments provide symptomatic relief, but do not halt the disease’s progression. OS plays a crucial role in AD pathogenesis [...] Read more.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier dysfunction, oxidative stress (OS), and neuroinflammation. Current treatments provide symptomatic relief, but do not halt the disease’s progression. OS plays a crucial role in AD pathogenesis by promoting Aβ accumulation. Nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the antioxidant response, influencing genes involved in OS mitigation, mitochondrial function, and inflammation. Dysregulation of NRF2 is implicated in AD, making it a promising therapeutic target. Emerging evidence suggests that adherence to a Mediterranean diet (MD), which is particularly rich in polyphenols from extra virgin olive oil (EVOO), is associated with improved cognitive function and a reduced risk of mild cognitive impairment. Polyphenols can activate NRF2, enhancing endogenous antioxidant defenses. This study employs a computational approach to explore the potential of bioactive compounds in EVOO to modulate NRF2-related pathways in AD. We analyzed transcriptomic data from AD and EVOO-treated samples to identify NRF2-associated genes, and used chemical structure-based analysis to compare EVOO’s bioactive compounds with known NRF2 activators. Enrichment analysis was performed to identify common biological functions between NRF2-, EVOO-, and AD-related pathways. Our findings highlight important factors and biological functions that provide new insight into the molecular mechanisms through which EVOO consumption might influence cellular pathways associated with AD via modulation of the NRF2 pathway. The presented approach provides a different perspective in the discovery of compounds that may contribute to neuroprotective mechanisms in the context of AD. Full article

(This article belongs to the Special Issue Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection—2nd Edition)

26 pages, 1613 KiB

Open AccessArticle

Olive Oil-Based Lipid Coating as a Precursor Organogel for Postharvest Preservation of Lychee: Efficacy Combined with Polyamide/Polyethylene Packaging Under Passive Atmosphere

by Alessandra Culmone, Roberta Passafiume, Pasquale Roppolo, Ilenia Tinebra, Vincenzo Naselli, Alfonso Collura, Antonino Pirrone, Luigi Botta, Alessandra Carrubba, Nicola Francesca, Raimondo Gaglio and Vittorio Farina

Gels 2025, 11(8), 608; https://doi.org/10.3390/gels11080608 (registering DOI) - 2 Aug 2025

Abstract

Lychee (Lychee chinensis Sonn.) is a tropical fruit highly appreciated for its vivid red color, sweet flavor, and nutritional properties. However, it is highly perishable, with postharvest losses often due to oxidative browning and dehydration. This study evaluated the organic olive oil [...] Read more.

Lychee (Lychee chinensis Sonn.) is a tropical fruit highly appreciated for its vivid red color, sweet flavor, and nutritional properties. However, it is highly perishable, with postharvest losses often due to oxidative browning and dehydration. This study evaluated the organic olive oil coating (OC), a natural lipidic system with the potential to act as a precursor for organogel development, combined with polyamide/polyethylene (PA/PE) packaging under passive modified atmosphere. Fruits were harvested at commercial maturity and divided into two groups: OC-treated and untreated control (CTR). Both groups were stored at 5 ± 1 °C and 90 ± 5% relative humidity and analyzed on days 0, 3, 6, and 9. The OC-treated fruits showed significantly better retention of physical, chemical, microbiological, and sensory qualities. The coating reduced oxidative stress and enzymatic browning, preserving color and firmness. The PA/PE packaging regulated gas exchange, lowering oxygen levels and delaying respiration and ripening. As a result, OC fruits had lower weight loss, a slower increase in browning index and maturity index, and better visual and sensory scores than the CTR group. This dual strategy proved effective in extending shelf life while maintaining the fruit’s appearance, flavor, and nutritional value. It represents a sustainable and natural approach to enhancing the postharvest stability of lychee. Full article

(This article belongs to the Special Issue Edible Coatings and Film: Gel-Based Innovations)

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15 pages, 1908 KiB

Open AccessArticle

Chitosan–Glycerol Injectable Hydrogel for Intratumoral Delivery of Macromolecules

by Robert L. Kobrin, Siena M. Mantooth, Abigail L. Mulry, Desmond J. Zaharoff and David A. Zaharoff

Gels 2025, 11(8), 607; https://doi.org/10.3390/gels11080607 (registering DOI) - 2 Aug 2025

Abstract

Intratumoral injections of macromolecules, such as biologics and immunotherapeutics, show promise in overcoming dose-limiting side effects associated with systemic injections and improve treatment efficacy. However, the retention of injectates in the tumor microenvironment is a major underappreciated challenge. High interstitial pressures and dense [...] Read more.

Intratumoral injections of macromolecules, such as biologics and immunotherapeutics, show promise in overcoming dose-limiting side effects associated with systemic injections and improve treatment efficacy. However, the retention of injectates in the tumor microenvironment is a major underappreciated challenge. High interstitial pressures and dense tumor architectures create shear forces that rapidly expel low-viscosity solutions post-injection. Injectable hydrogels may address these concerns by providing a viscoelastic delivery vehicle that shields loaded therapies from rapid expulsion from the tumor. A chitosan–glycerol hydrogel was thus developed and characterized with the goal of improving the injection retention of loaded therapeutics. The gelation parameters and mechanical properties of the hydrogel were explored to reveal a shear-thinning gel that is injectable through a 27-gauge needle. Biocompatibility studies demonstrated that the chitosan–glycerol hydrogel was nontoxic. Retention studies revealed significant improvements in the retention of model therapeutics when formulated with the chitosan–glycerol hydrogel compared to less-viscous solutions. Finally, release studies showed that there was a sustained release of model therapeutics of various molecular sizes from the hydrogel. Overall, the chitosan–glycerol hydrogel demonstrated injectability, enhanced retention, biocompatibility, and sustained release of macromolecules, indicating its potential for future clinical use in intratumoral macromolecule delivery. Full article

(This article belongs to the Special Issue Gels: 10th Anniversary)

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19 pages, 4538 KiB

Open AccessArticle

Structural Optimization of Numerical Simulation for Spherical Grid-Structured Microporous Aeration Reactor

by Yipeng Liu, Hui Nie, Yangjiaming He, Yinkang Xu, Jiale Sun, Nan Chen, Saihua Huang, Hao Chen and Dongfeng Li

Water 2025, 17(15), 2302; https://doi.org/10.3390/w17152302 (registering DOI) - 2 Aug 2025

Abstract

As the core equipment for efficient wastewater treatment, the internal structure of microporous aeration bioreactors directly determines the mass transfer efficiency and treatment performance. Based on Computational Fluid Dynamics (CFD) technology, this study explores the optimization mechanism of a Spherical Grid-Structured on the [...] Read more.

As the core equipment for efficient wastewater treatment, the internal structure of microporous aeration bioreactors directly determines the mass transfer efficiency and treatment performance. Based on Computational Fluid Dynamics (CFD) technology, this study explores the optimization mechanism of a Spherical Grid-Structured on the internal flow field of the reactor through a 3D numerical simulation system, aiming to improve the aeration efficiency and resource utilization. This study used a combination of experimental and numerical simulations to compare and analyze different configurations of the Spherical Grid-Structure. The simulation results show that the optimal equilibrium of the flow field inside the reactor is achieved when the diameter of the grid sphere is 2980 mm: the average flow velocity is increased by 22%, the uniformity of the pressure distribution is improved by 25%, and the peak turbulent kinetic energy is increased by 30%. Based on the Kalman vortex street theory, the periodic vortex induced by the grid structure refines the bubble size to 50–80 microns, improves the oxygen transfer efficiency by 20%, increases the spatial distribution uniformity of bubbles by 35%, and significantly reduces the dead zone volume from 28% to 16.8%, which is a decrease of 40%. This study reveals the quantitative relationship between the structural parameters of the grid and the flow field characteristics through a pure numerical simulation, which provides a theoretical basis and quantifiable optimization scheme for the structural design of the microporous aeration bioreactor, which is of great significance in promoting the development of low-energy and high-efficiency wastewater treatment technology. Full article

(This article belongs to the Section Wastewater Treatment and Reuse)

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22 pages, 3797 KiB

Open AccessArticle

Amygdalin-Doped Biopolymer Composites as Potential Wound Dressing Films: In Vitro Study on E. coli and S. aureus

by Dorinel Okolišan, Gabriela Vlase, Mihaela Maria Budiul, Mariana Adina Matica and Titus Vlase

Gels 2025, 11(8), 609; https://doi.org/10.3390/gels11080609 (registering DOI) - 2 Aug 2025

Abstract

Biopolymer films doped with active substances may become a promising alternative to traditional dressings for skin wounds, as they can deliver drugs while maintaining wound moisture, thus contributing to the healing process. This article describes the preparation of amygdalin-doped biopolymer films for in [...] Read more.

Biopolymer films doped with active substances may become a promising alternative to traditional dressings for skin wounds, as they can deliver drugs while maintaining wound moisture, thus contributing to the healing process. This article describes the preparation of amygdalin-doped biopolymer films for in vitro testing against the bacterial strains typical of chronic wounds: E. coli and S. aureus. Thus, FTIR characterization suggests minimal chemical interaction between amygdalin and the biopolymer matrix components, indicating potential compatibility, while thermogravimetric analysis highlights the thermal behavior of the films as well as the influence of the polymer matrix composition on the amount of bound water and the shift of T_peak value for the decomposition process of the base polymer. Moreover, the identity of the secondary biopolymer (gelatin or CMC) significantly influences film morphology and antibacterial performance. Full article

(This article belongs to the Special Issue Novel Functional Gels for Biomedical Applications (2nd Edition))

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16 pages, 8522 KiB

Open AccessArticle

Plant Extracts as Modulators of the Wound Healing Process—Preliminary Study

by Anna Herman, Aleksandra Leska, Patrycja Wińska and Andrzej Przemysław Herman

Int. J. Mol. Sci. 2025, 26(15), 7490; https://doi.org/10.3390/ijms26157490 (registering DOI) - 2 Aug 2025

Abstract

The treatment of chronic wounds is one of the most complex therapeutic problems of modern medicine. It leads to patients’ protracted recovery, generating high treatment costs. Herbal products may be useful in the treatment of chronic wounds via a wide range of pharmacological [...] Read more.

The treatment of chronic wounds is one of the most complex therapeutic problems of modern medicine. It leads to patients’ protracted recovery, generating high treatment costs. Herbal products may be useful in the treatment of chronic wounds via a wide range of pharmacological properties and multidirectional effects on the wound healing phases. The study aims to determine the ability of selected plant extracts to modulate the processes involved in wound healing. The antimicrobial (MIC, MBC, MFC) and antioxidant (ABTS, DPPH) activities, cytotoxicity (MTT test), scratch wound test, and collagen assay were tested. R. canina (MBC 0.39 mg/mL) and V. venifera (MBC 3.13 mg/mL) extracts had bactericidal activities against P. aeruginosa and S. aureus, respectively. The V. vinifera extract showed the highest antioxidant activity in both ABTS (EC50 0.078 mg/mL) and DPPH (EC50 0.005 mg/mL) methods. The percentage of wound closure observed for C. cardunculus, R. rosea, and R. canina extracts with HaCaT, and V. vinifera extract with Hs27 cells was set as 100%. V. vinifera extract (50 μg/mL) stimulated collagen synthesis 5.16 times more strongly than ascorbic acid. Our preliminary study showed that some plant extracts may be promising modulators of the wound healing process, although further in-depth studies are necessary to determine their effectiveness in the in vivo model. Full article

(This article belongs to the Special Issue Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition)

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11 pages, 715 KiB

Open AccessArticle

One Health Approach to Trypanosoma cruzi: Serological and Molecular Detection in Owners and Dogs Living on Oceanic Islands and Seashore Mainland of Southern Brazil

by Júlia Iracema Moura Pacheco, Louise Bach Kmetiuk, Melissa Farias, Gustavo Gonçalves, Aaronson Ramathan Freitas, Leandro Meneguelli Biondo, Cristielin Alves de Paula, Ruana Renostro Delai, Cláudia Turra Pimpão, João Henrique Perotta, Rogério Giuffrida, Vamilton Alvares Santarém, Helio Langoni, Fabiano Borges Figueiredo, Alexander Welker Biondo and Ivan Roque de Barros Filho

Trop. Med. Infect. Dis. 2025, 10(8), 220; https://doi.org/10.3390/tropicalmed10080220 (registering DOI) - 2 Aug 2025

Abstract

Via a One Health approach, this study concomitantly assessed the susceptibility of humans and dogs to Trypanosoma cruzi infections on three islands and in two mainland seashore areas of southern Brazil. Human serum samples were tested using an enzyme-linked immunosorbent assay (ELISA) to [...] Read more.

Via a One Health approach, this study concomitantly assessed the susceptibility of humans and dogs to Trypanosoma cruzi infections on three islands and in two mainland seashore areas of southern Brazil. Human serum samples were tested using an enzyme-linked immunosorbent assay (ELISA) to detect anti-T. cruzi antibodies, while dog serum samples were tested using indirect fluorescent antibodies in an immunofluorescence assay (IFA). Seropositive human and dog individuals were also tested using quantitative polymerase chain reaction (qPCR) in corresponding blood samples. Overall, 2/304 (0.6%) human and 1/292 dog samples tested seropositive for T. cruzi by ELISA and IFA, respectively, and these cases were also molecularly positive for T. cruzi by qPCR. Although a relatively low positivity rate was observed herein, these cases were likely autochthonous, and the individuals may have been infected as a consequence of isolated events of disturbance in the natural peridomicile areas nearby. Such a disturbance could come in the form of a fire or deforestation event, which can cause stress and parasitemia in wild reservoirs and, consequently, lead to positive triatomines. In conclusion, T. cruzi monitoring should always be conducted in suspicious areas to ensure a Chagas disease-free status over time. Further studies should also consider entomological and wildlife surveillance to fully capture the transmission and spread of T. cruzi on islands and in seashore mainland areas of Brazil and other endemic countries. Full article

(This article belongs to the Section One Health)

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12 pages, 3794 KiB

Open AccessArticle

Enhanced Energy Storage Properties of Ba_0.96Ca_0.04TiO₃ Ceramics Through Doping Bi(Li_1/3Zr_2/3)O₃

by Zhiwei Li, Dandan Zhu, Xuqiang Ding, Lingling Cui and Junlong Wang

Coatings 2025, 15(8), 906; https://doi.org/10.3390/coatings15080906 (registering DOI) - 2 Aug 2025

Abstract

The (1−x)Ba_0.96Ca_0.04TiO₃−xBi(Li_1/3Zr_2/3)O₃ (x = 0.03–0.15) ceramics were fabricated via the traditional solid reaction method. Characterization results revealed that each component exhibited a pure perovskite structure, and the average grain size significantly diminishes [...] Read more.

The (1−x)Ba_0.96Ca_0.04TiO₃−xBi(Li_1/3Zr_2/3)O₃ (x = 0.03–0.15) ceramics were fabricated via the traditional solid reaction method. Characterization results revealed that each component exhibited a pure perovskite structure, and the average grain size significantly diminishes with increasing x. The (1−x)Ba_0.96Ca_0.04TiO₃−xBi(Li_1/3Zr_2/3)O₃ ceramics exhibited prominent relaxor ferroelectric behavior, whose characteristic narrow hysteresis loops effectively enhanced the energy storage performance of the material. Most importantly, the composition with x = 0.10 demonstrated exceptional energy storage properties at 150 kV/cm, achieving a high recoverable energy storage density (W_rec = 1.91 J/cm³) and excellent energy efficiency (η = 90.87%). Under the equivalent electric field, this composition also displayed a superior pulsed discharge performance, including a high current density (871 A/cm²), a high power density (67.3 MW/cm³), an ultrafast discharge time (t_0.9 = 109 ns), and a discharged energy density of 1.47 J/cm³. These results demonstrate that the (1−x)Ba_0.96Ca_0.04TiO₃−xBi(Li_1/3Zr_2/3)O₃ ceramic system establishes a promising design paradigm for the creation and refinement of next-generation dielectrics for pulse power applications. Full article

(This article belongs to the Section Ceramic Coatings and Engineering Technology)

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