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Tropical Medicine and Infectious Disease, Volume 7, Issue 12

December 2022 - 56 articles

Cover Story: Cancer and parasitic diseases share similarities that allow for the co-development of new drugs with antiproliferative profiles. We describe herein the design of a series of 1,2,4-oxadiazoles active against both cancer cells and trypanosomatid parasites. One hit compound was identified during in vitro evaluation against drug-sensitive and drug-resistant chronic myeloid leukemia cell lines, Trypanosoma cruzi and Leishmania amazonensis. In silico studies indicate a correlation between in vitro activity and interaction with tubulin at the colchicine binding site. Additionally, ADMET in silico predictions and experimental studies with human serum albumin indicate that the compounds possess a favorable druggability potential due to their physicochemical, pharmacokinetic, and toxicity profiles. View this paper
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Articles (56)

  • Article
  • Open Access
9 Citations
4,565 Views
12 Pages

Distribution of Mycobacterium tuberculosis Lineages and Drug Resistance in Upper Myanmar

  • Aye Nyein Phyu,
  • Si Thu Aung,
  • Prasit Palittapongarnpim,
  • Kyaw Ko Ko Htet,
  • Surakameth Mahasirimongkol,
  • Htin Lin Aung,
  • Angkana Chaiprasert and
  • Virasakdi Chongsuvivatwong

Mycobacterium tuberculosis complex (MTBC) is divided into 9 whole genome sequencing (WGS) lineages. Among them, lineages 1–4 are widely distributed. Multi-drug resistant tuberculosis (MDR-TB) is a major public health threat. For effective TB co...

  • Article
  • Open Access
3 Citations
2,439 Views
14 Pages

COVID-19 Risk Perception and Prevention Practices among High- and Low-Density Populations in Bangladesh: A Mixed-Methods Study

  • Syed Moinuddin Satter,
  • Kamal Ibne Amin Chowdhury,
  • Refah Tamanna,
  • Zarin Abdullah,
  • S. M. Zafor Shafique,
  • Md Saiful Islam,
  • Nadia Ali Rimi,
  • Muhammad Rashedul Alam,
  • Arifa Nazneen and
  • Mustafizur Rahman
  • + 9 authors

We aimed to explore coronavirus disease 2019 (COVID-19) risk perception and prevention practices among people living in high- and low-population density areas in Dhaka, Bangladesh. A total of 623 patients with confirmed COVID-19 agreed to participate...

  • Article
  • Open Access
8 Citations
3,140 Views
14 Pages

Evaluation of Methods for Collecting Mosquitoes (Culicidae: Diptera) in Canopy and Ground Strata in the Brazilian Savanna

  • Luis Filipe Mucci,
  • Eduardo Sterllino Bergo,
  • Juliana Telles de Deus,
  • Simone Luchetta Reginato,
  • Mariza Pereira and
  • Vera Lucia Fonseca de Camargo-Neves

The hand-net is the standard method for capturing mosquitoes with sylvatic diurnal activity in disease outbreaks in Brazil. However, occupational risks and biases related to the collectors’ abilities and attractiveness are important limitations...

  • Article
  • Open Access
15 Citations
3,435 Views
13 Pages

Trypanosoma cruzi Parasite Burdens of Several Triatomine Species in Colombia

  • Natalia Velásquez-Ortiz,
  • Carolina Hernández,
  • Omar Cantillo-Barraza,
  • Nathalia Ballesteros,
  • Lissa Cruz-Saavedra,
  • Giovanny Herrera,
  • Luz Stella Buitrago,
  • Hugo Soto,
  • Manuel Medina and
  • Jatney Palacio
  • + 7 authors

Trypanosoma cruzi, the causal agent of Chagas disease, is mainly transmitted by insects of the Triatominae subfamily. In Colombia, there are 26 triatomine species, and 16 of them are naturally infected with the parasite. The parasite loads of natural...

  • Review
  • Open Access
14 Citations
4,475 Views
10 Pages

Cutaneous Leishmaniasis Emergence in Southeastern Mexico: The Case of the State of Yucatan

  • Elsy B. Canché-Pool,
  • Jesús A. Panti-May,
  • Hugo A. Ruiz-Piña,
  • Marco Torres-Castro,
  • Francisco J. Escobedo-Ortegón,
  • Paulino Tamay-Segovia,
  • Selene Blum-Domínguez,
  • Jimmy R. Torres-Castro and
  • Enrique Reyes-Novelo

Environmental changes triggered by deforestation, urban expansion and climate change are present-day drivers of the emergence and reemergence of leishmaniasis. This review describes the current epidemiological scenario and the feasible influence of e...

  • Case Report
  • Open Access
5 Citations
2,109 Views
6 Pages

First Human Usutu Virus Reported in Asti (Piedmont, Italy, August 2022) and Early Follow-Up

  • Tommaso Lupia,
  • Fabio Paolo Marletto,
  • Ilvana Tiziana Scuvera,
  • Roberta Bosio,
  • Barbara Rizzello,
  • Valentina Fornari,
  • Daniela Maria Luisa Vivenza,
  • Valeria Ghisetti,
  • Maria Teresa Brusa and
  • Silvia Corcione
  • + 1 author

The Usutu virus (USUV) has recently attracted the attention of scientists because of its rapid spread across Europe and its growth over the previous seasons in Italy. Here, we describe the first case of USUV infection in Asti, Piedmont region, Italy....

  • Article
  • Open Access
4 Citations
3,795 Views
15 Pages

Different In Vitro Drug Susceptibility Profile of Plasmodium falciparum Isolates from Two Adjacent Areas of Northeast Myanmar and Molecular Markers for Drug Resistance

  • Mengxi Duan,
  • Yao Bai,
  • Shuang Deng,
  • Yonghua Ruan,
  • Weilin Zeng,
  • Xiaosong Li,
  • Xun Wang,
  • Wei Zhao,
  • Hui Zhao and
  • Kemin Sun
  • + 6 authors

The Greater Mekong Subregion (GMS) is the epicenter of antimalarial drug resistance. We determined in vitro susceptibilities to 11 drugs of culture-adapted Plasmodium falciparum isolates from adjacent areas (Laiza and Muse) along the China–Myan...

  • Article
  • Open Access
2 Citations
4,130 Views
8 Pages

Individuals’ Vulnerability Based Active Surveillance for TB: Experiences from India

  • Shibu K. Balakrishnan,
  • Rakesh P. Suseela,
  • Sunilkumar Mrithyunjayan,
  • Manu E. Mathew,
  • Suresh Varghese,
  • Shubin Chenayil,
  • Suja Aloysius,
  • Twinkle Prabhakaran and
  • Sreenivas A. Nair

Community-based active TB case finding (ACF) has become an essential part of TB elimination efforts in high-burden settings. In settings such as the state of Kerala in India, which has reported an annual decline of 7.5% in the estimated TB incidence...

  • Article
  • Open Access
4 Citations
2,399 Views
8 Pages

Diagnostic Performance of Plasmodium falciparum Histidine-Rich Protein-2 Antigen-Specific Rapid Diagnostic Test in Children at the Peripheral Health Care Level in Nanoro (Burkina Faso)

  • Massa dit Achille Bonko,
  • Marc Christian Tahita,
  • Francois Kiemde,
  • Palpouguini Lompo,
  • Petra F. Mens,
  • Halidou Tinto and
  • Henk. D. F. H. Schallig

(1) Background: Malaria control has strongly benefited from the implementation of rapid diagnostic tests (RDTs). The malaria RDTs used in Burkina Faso, as per the recommendation of the National Malaria Control Program, are based on the detection of h...

  • Review
  • Open Access
14 Citations
5,772 Views
15 Pages

Human cytomegalovirus (HCMV) is ubiquitous worldwide and elicits global health problems. The diseases associated with HCMV are a serious threat to humans, especially for the sick, infant, elderly and immunocompromised/immunodeficient individuals. Alt...

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Trop. Med. Infect. Dis. - ISSN 2414-6366