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Journal of Fungi, Volume 11, Issue 12

December 2025 - 74 articles

Cover Story: Coccidioidomycosis (CM), also known as Valley Fever, is endemic to the alkaline deserts of North and South America. Inhalation of spores from the causative agents Coccidioides immitis and Coccidioides posadasii often presents as flu-like symptoms or pneumonia. Severe disseminated CM, while rare, often requires long-term antifungal treatment. Current CM treatments focus on azoles, such as fluconazole and itraconazole, and the polyene amphotericin B. However, due to the concern of polyene cytotoxicity and evolving azole-resistant fungal strains, development of new antifungals against CM is urgently needed. This review highlights the limitations of current antifungal treatments and the efforts to address the gap through surveys of emerging antifungal compounds undergoing clinical trials and drug repurposing via high-throughput screening. View this paper
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Articles (74)

  • Article
  • Open Access
426 Views
13 Pages

Vaccine-Mediated Protection of Mice Against African and Asian Clinical Strains of Cryptococcus neoformans

  • Diana Carlson,
  • Ruiying Wang,
  • Zachary Hastings,
  • Lorena V. N. Oliveira,
  • Maureen M. Hester,
  • Nicolle Rodriguez,
  • Gabriel Kristian Pedersen,
  • Jennifer L. Tenor,
  • John R. Perfect and
  • Charles A. Specht
  • + 1 author

16 December 2025

Infections with strains of the Cryptococcus neoformans species complex are responsible for over 100,000 deaths per year, predominantly due to meningitis in immunocompromised individuals. Despite much research, there are no licensed fungal vaccines av...

  • Article
  • Open Access
720 Views
19 Pages

Optimized Selective Media Enhance the Isolation and Characterization of Gut-Derived Probiotic Yeasts

  • Kevin Mok,
  • Kwantida Popitool,
  • Areerat Songla,
  • Tawisa Pongsuwanporn,
  • Pitchsupang Torrungruang,
  • Sunee Nitisinprasert,
  • Jiro Nakayama and
  • Massalin Nakphaichit

15 December 2025

This study applied a guided culturomics workflow to isolate and characterize gut-associated yeasts as probiotic candidates. Culture conditions were optimized using Dixon agar and Modified Schädler Agar with a moderate antibiotic cocktail (colist...

  • Article
  • Open Access
470 Views
17 Pages

15 December 2025

Extracellular vesicles (EVs) secreted by Fusarium oxysporum play an important role in the process of its infestation of the host, but the in vitro research system for EVs of F. oxysporum (Fo-EVs) has not yet been improved, and the mechanism of its ac...

  • Article
  • Open Access
418 Views
19 Pages

Effect of Heat Stress on the Biosynthesis of Exopolysaccharides from Rhodotorula glutinis YM25079 and Its Underlying Mechanisms

  • Rong Huang,
  • Minrao Lu,
  • Caina Guo,
  • Taishen Wang,
  • Jingdie Fan,
  • Chengmei Zhang,
  • Jingwen Qiu,
  • Yuan Chen and
  • Qi Zhang

14 December 2025

In this study, the effect of heat stress on the synthesis and the structural and physicochemical properties of exopolysaccharides (EPSs) from Rhodotorula glutinis YM25079 as well as its underlying mechanisms were explored. The results showed that the...

  • Article
  • Open Access
458 Views
24 Pages

Genomic and Transcriptomic Insights into Carbon-Source and Temporal Induction of a Diverse Set of Lignocellulolytic Enzymes in Irpex lacteus QJ

  • Liye Song,
  • Baorui Liu,
  • Qijun Zhu,
  • Kun Meng,
  • Hongying Cai,
  • Yunsheng Han,
  • Weiwei Liu and
  • Peilong Yang

13 December 2025

The white-rot fungus Irpex lacteus is recognized for its strong ligninolytic and polysaccharide-degrading capacity, but the key advantages in degrading lignocellulose and the regulation of its enzyme systems remain poorly understood. In this study, w...

  • Article
  • Open Access
480 Views
19 Pages

The Effects of Subalpine Forest Succession on Soil Fungal Community Composition and Diversity Vary with Soil Depth and Trophic Mode on the Eastern Qinghai–Tibetan Plateau

  • Miao Chen,
  • Jian Chen,
  • Xiaoqiang Tang,
  • Shun Liu,
  • Hongshuang Xing,
  • Xuhua Li,
  • Lei Cai,
  • Zhengjingru Xu,
  • Wenhao Miao and
  • Xia Hu
  • + 1 author

12 December 2025

Soil fungi play an indispensable role in maintaining soil ecosystem functions. However, how forest succession and soil depth interactively shape fungal community composition and diversity remains poorly understood. To address this, we investigated fu...

  • Article
  • Open Access
633 Views
37 Pages

Diversity of Sordariales Fungi: Identification of Seven New Species of Naviculisporaceae Through Morphological Analyses and Genome Sequencing

  • Narumon Tangthirasunun,
  • Valérie Gautier,
  • Christophe Lalanne,
  • Lucas Bonometti,
  • Sandrine Cros-Arteil,
  • Richard D. Hayes,
  • Sarah Calhoun,
  • Robert Riley,
  • Jasmyn Pangilinan and
  • Anna Lipzen
  • + 5 authors

12 December 2025

Thanks to next-generation sequencing (NGS) technologies, the diversity of fungi can now be investigated through the analysis of their genome sequences. Naviculisporaceae is a family within the Sordariales, whose diversity is not well-known, with only...

  • Article
  • Open Access
450 Views
21 Pages

11 December 2025

Panax notoginseng is a traditional medicinal and food-homologous plant in China; however, root rot, primarily caused by Fusarium solani, has become a devastating disease that severely compromises the yield and quality of P. notoginseng. In this study...

  • Article
  • Open Access
487 Views
19 Pages

11 December 2025

Deep-sea cold seep ecosystems, known for their unique geochemical niches and chemosynthetic communities, harbor numerous “dark matter fungi (DMF)” that remain understudied compared to their bacterial and archaeal counterparts. Integrating...

  • Article
  • Open Access
500 Views
24 Pages

11 December 2025

Functionally similar to a plant vacuole or a mammalian lysosome, the fungal vacuole plays a vital role in many cellular processes. Most studies of the vacuole have been performed in the nonpathogenic yeast Saccharomyces cerevisiae; however, the vacuo...

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J. Fungi - ISSN 2309-608X