Fungal Cell Biology

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: 28 February 2026 | Viewed by 573

Special Issue Editor


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Guest Editor
Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, Brazil
Interests: microbiology; biochemistry and immunology; extracellular vesicles; infectious fungal diseases; therapeutic targets and prophylactic tools

Special Issue Information

Dear Colleagues,

Fungi are remarkable eukaryotic organisms characterized by unique cellular structures and complex developmental processes that enable them to inhabit a wide array of ecological niches. Central to their biology is the cell wall—a dynamic, polysaccharide-rich structure that ensures cellular integrity, regulates morphogenesis, and serves as their primary interface with the external environment. The essential role of the cell wall, coupled with the fungal-specific enzymes involved in its biosynthesis, makes it an attractive target for antifungal therapies. Antifungal agents targeting the cell wall have significant therapeutic potential, though they too face the challenges posed by evolving resistance mechanisms.

Recent advances in fungal cell biology have shed light on critical aspects of hyphal growth, polarized cell extension, intracellular trafficking, and the formation of complex multicellular structures, such as mycelia and fruiting bodies. Nonetheless, numerous fundamental questions remain unanswered. Importantly, the interactions between fungal cells and the host immune system are a key area of investigation. Understanding how fungal cell structures modulate or evade immune responses is crucial for elucidating pathogenic mechanisms and developing novel therapeutic strategies, particularly in the context of opportunistic infections in immunocompromised individuals.

This Special Issue invites contributions that explore the cellular and molecular biology of fungi, with a particular interest in studies addressing the structure and function of the fungal cell wall, morphogenetic pathways, host–pathogen interactions, and the cellular basis of immune recognition and response. Submissions employing advanced methodologies—including genetic, biochemical, and imaging approaches—are especially encouraged, as we aim to showcase cutting-edge research that deepens our understanding of fungal cell biology and its biomedical implications.

We look forward to receiving your contributions.

Prof. Dr. Fausto Almeida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal cell biology
  • fungal cell wall
  • host–pathogen interactions
  • antifungal targets
  • morphogenesis
  • immune evasion

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Published Papers (1 paper)

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Review

20 pages, 3541 KiB  
Review
Immunoregulation in Fungal Infections: A Review and Update on the Critical Role of Myeloid-Derived Suppressor Cells
by Valéria de Lima Kaminski, Ana Luiza Oliveira Menezes, Kauan Gonçalves de Lima, Stephani Leonelo de Almeida, Diego Vinícius Alves da Silva, Filipe Nogueira Franco, Nycolas Willian Preite and Flávio Vieira Loures
J. Fungi 2025, 11(7), 496; https://doi.org/10.3390/jof11070496 - 30 Jun 2025
Viewed by 466
Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immune cells that play a central role in regulating host immune responses during fungal infections. Their recruitment is mediated by pathogen recognition receptors, particularly Dectin-1 and CARD9 signaling, which promote the production of reactive [...] Read more.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immune cells that play a central role in regulating host immune responses during fungal infections. Their recruitment is mediated by pathogen recognition receptors, particularly Dectin-1 and CARD9 signaling, which promote the production of reactive oxygen species (ROS) and IL-1β. Once activated, MDSCs suppress T-cell and natural killer cell functions through immunosuppressive cytokines like IL-10 and TGF-β, as well as enzymes such as arginase-1 and indoleamine 2,3-dioxygenase 1 (IDO-1). This review explores the role of MDSCs in fungal infections caused by Candida spp., Paracoccidioides brasiliensis, Aspergillus spp., and Cryptococcus neoformans, emphasizing their impact on immune modulation and disease progression. The emerging evidence suggests that fungal bioactive compounds, such as polysaccharides, can influence MDSC activity and restore immune balance. Notably, therapies targeting MDSCs have demonstrated promise in both fungal infections. In particular, infections with P. brasiliensis and C. neoformans show improved T-cell responses following MDSC-targeted interventions. Additionally, polysaccharides from Grifola frondosa and exposure to Aspergillus sydowii affect MDSC behavior, supporting the potential of modulating these cells therapeutically. Together, these findings highlight the relevance of MDSCs in fungal pathogenesis and underscore their potential as targets for immunotherapeutic strategies in infectious diseases. Full article
(This article belongs to the Special Issue Fungal Cell Biology)
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