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Journal of Fungi, Volume 11, Issue 12

December 2025 - 74 articles

Cover Story: Coccidioidomycosis (CM), also known as Valley Fever, is endemic to the alkaline deserts of North and South America. Inhalation of spores from the causative agents Coccidioides immitis and Coccidioides posadasii often presents as flu-like symptoms or pneumonia. Severe disseminated CM, while rare, often requires long-term antifungal treatment. Current CM treatments focus on azoles, such as fluconazole and itraconazole, and the polyene amphotericin B. However, due to the concern of polyene cytotoxicity and evolving azole-resistant fungal strains, development of new antifungals against CM is urgently needed. This review highlights the limitations of current antifungal treatments and the efforts to address the gap through surveys of emerging antifungal compounds undergoing clinical trials and drug repurposing via high-throughput screening. View this paper
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Articles (74)

  • Review
  • Open Access
456 Views
22 Pages

18 December 2025

Powdery mildew poses a persistent threat to global vegetable and fruit production, particularly affecting leafy crops such as lettuce, spinach, and cucurbits. Conventional control strategies including chemical fungicides, biological agents, and resis...

  • Article
  • Open Access
563 Views
18 Pages

Antifungal Susceptibility and Resistance-Associated Gene Expression in Nosocomial Candida Isolates

  • Fabiola Berenice Hernandez-Reyes,
  • Luis Alfonso Muñoz-Miranda,
  • Manuel R. Kirchmayr,
  • Pablo César Ortiz-Lazareno,
  • Rafael Cortés-Zárate,
  • Maricarmen Iñiguez-Moreno,
  • Heriberto Jacobo-Cuevas and
  • Cesar Arturo Nava-Valdivia

18 December 2025

Background: Nosocomial infections represent a significant clinical burden due to high morbidity, mortality and healthcare costs. Invasive fungal infections, particularly those caused by Candida species, are of growing concern due to increasing antifu...

  • Article
  • Open Access
379 Views
14 Pages

Extracts of the Algerian Fungus Phlegmacium herculeum: Chemical Analysis, Antioxidant, Antibacterial, and Cytotoxicity Evaluation

  • Roukia Zatout,
  • Stefania Garzoli,
  • Lounis Youcef Khodja,
  • Ouided Abdelaziz,
  • Maria Michela Salvatore,
  • Anna Andolfi,
  • Marco Masi and
  • Alessio Cimmino

18 December 2025

This study reports the first molecularly confirmed occurrence of Phlegmacium herculeum in Algeria, identified through morphological features and ITS sequence analysis (GenBank accession: PQ133121). Phytochemical profiling revealed a diverse compositi...

  • Brief Report
  • Open Access
439 Views
8 Pages

Potato Elicitor Peptide StPep1 Enhances Resistance to Phytophthora infestans in Solanum tuberosum

  • Alexander Skripnikov,
  • Tatiana Suprunova,
  • Natalia O. Kalinina and
  • Michael Taliansky

18 December 2025

Plant peptides represent a novel molecular tool in crop science due to their essential regulatory roles in plant growth, development, and responses to biotic and abiotic stresses. Although numerous bioactive plant peptides have been identified, a maj...

  • Review
  • Open Access
788 Views
20 Pages

The Conservation Crisis of Ophiocordyceps sinensis: Strategies, Challenges, and Sustainable Future of Artificial Cultivation

  • Zhoujian He,
  • Meng Ye,
  • Huaxue Wu,
  • Dan Liang,
  • Jie Huan,
  • Yuan Yao,
  • Xinyue Wu and
  • Xiaomei Luo

18 December 2025

Ophiocordyceps sinensis, a fungus revered in traditional Asian medicine, is critically endangered due to climate change and overharvesting. Artificial cultivation is thus essential to meet demand and promote conservation. This review systematically a...

  • Article
  • Open Access
565 Views
20 Pages

Five New Species of Gibellula (Hypocreales, Cordycipitaceae) from China

  • Bo Tu,
  • Hui Chen,
  • Xu Zhang,
  • Yu-Hu Guan,
  • De-Xiang Tang,
  • Qi-Rui Li and
  • Yao Wang

17 December 2025

The genus Gibellula (Cordycipitaceae, Hypocreales) comprises highly specialized, obligate pathogens that exclusively parasitize spiders. In this study, five new species were delimited based on morphological and phylogenetic evidence from a six-locus...

  • Article
  • Open Access
415 Views
16 Pages

Unravelling the Potential of Fungal Division of Labour in the Laccase Producer Coriolopsis trogii MUT3379 Through Protoplast Formation and Regeneration

  • Luca Mellere,
  • Adriana Bava,
  • Jean Armengaud,
  • Francesca Berini,
  • Flavia Marinelli,
  • Giovanna Cristina Varese,
  • Federica Spina and
  • Fabrizio Beltrametti

17 December 2025

The white-rot fungus Coriolopsis trogii MUT3379 produces Lac3379-1 laccase at high yields due to the previous development of a robust fermentation process. Throughout the extended use of this strain, we observed the occurrence of substrate-specific g...

  • Article
  • Open Access
382 Views
8 Pages

17 December 2025

The fungal pathogen Candida albicans can infect diverse tissues, a reflection of its broad metabolic repertoire. The transcription factor Adr1 is required for utilization of several citric acid cycle intermediates that are found in tissue. Many Adr1-...

  • Article
  • Open Access
547 Views
22 Pages

Molecular and Morphological Identification and Pathogenicity of Fusarium Species Causing Melon Wilt in Russia

  • Irina Engalycheva,
  • Elena Kozar,
  • Alina Kameneva,
  • Maria Sletova,
  • Svetlana Vetrova,
  • Vera Chizhik,
  • Maria Kornilova and
  • Viktor Martynov

17 December 2025

Fusarium wilt of melon, caused by Fusarium fungi, results in sizeable economic losses worldwide. In Russia, data on the species composition of the causative pathogens of this disease on melon are lacking. From 2022 to 2025, 19 Fusarium isolates from...

  • Article
  • Open Access
564 Views
16 Pages

Three New Fungi from China: A Potentially Psychoactive Psilocybe and Two Deconica Species

  • Hai-Ying Feng,
  • Jia-Xin Li,
  • Wen-Qiang Yang,
  • Bin Cao and
  • Rui-Lin Zhao

16 December 2025

The saprotrophic genera Deconica and Psilocybe exhibit broad geographic distributions across temperate and subtropical biomes globally. Despite China’s rich fungal diversity, taxonomic studies of these genera remain limited, with few species pr...

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J. Fungi - ISSN 2309-608X