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Bioengineering, Volume 9, Issue 8

August 2022 - 77 articles

Cover Story: Shake flasks are often used as small-scale bioreactors during process development, especially in cell line and process parameter screening. In most cases, this is performed in a ‘black box’ system, without the use of sensors and with manual sampling. In our study, the use of online data (pH, DO and backscattered light) was evaluated in the cultivation of microorganisms such as E. coli and S. cerevisiae, as well as for plant (V. vinifera) and animal (CHO, HEK, High Five) cell cultures, to allow for the characterization of growth and oxygen consumption to be completed online. Subsequently, a data science workflow using the online data as input was developed and evaluated, enabling the automatic determination of key performance indicators such as the specific growth rate or the cell-specific oxygen uptake rate. View this paper
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Articles (77)

  • Systematic Review
  • Open Access
34 Citations
6,891 Views
35 Pages

Biodegradable Bone Implants as a New Hope to Reduce Device-Associated Infections—A Systematic Review

  • José C. C. Paiva,
  • Luís Oliveira,
  • Maria Fátima Vaz and
  • Sofia Costa-de-Oliveira

Bone fractures often require fixation devices that frequently need to be surgically removed. These temporary implants and procedures leave the patient more prone to developing medical device-associated infections, and osteomyelitis associated with tr...

  • Article
  • Open Access
6 Citations
2,751 Views
16 Pages

A Population-Based 3D Atlas of the Pathological Lumbar Spine Segment

  • Vincenza Sciortino,
  • Salvatore Pasta,
  • Tommaso Ingrassia and
  • Donatella Cerniglia

The spine is the load-bearing structure of human beings and may present several disorders, with low back pain the most frequent problem during human life. Signs of a spine disorder or disease vary depending on the location and type of the spine condi...

  • Article
  • Open Access
7 Citations
4,807 Views
22 Pages

Mesenchymal Stem Cell Use in Acute Tendon Injury: In Vitro Tenogenic Potential vs. In Vivo Dose Response

  • Kristin Bowers,
  • Lisa Amelse,
  • Austin Bow,
  • Steven Newby,
  • Amber MacDonald,
  • Xiaocun Sun,
  • David Anderson and
  • Madhu Dhar

Stem cell therapy for the treatment of tendon injury is an emerging clinical practice in the fields of human and veterinary sports medicine; however, the therapeutic benefit of intralesional transplantation of mesenchymal stem cells in tendonitis cas...

  • Review
  • Open Access
19 Citations
4,760 Views
29 Pages

Hepatocellular carcinoma (HCC) is the most common and serious type of primary liver cancer. HCC patients have a high death rate and poor prognosis due to the lack of clear signs and inadequate treatment interventions. However, the molecular pathways...

  • Article
  • Open Access
7 Citations
3,582 Views
14 Pages

Platelet concentrates (PCs), including platelet-rich plasma (PRP) gel and platelet-rich fibrin (PRF), are autologous blood-derived biomaterials containing numerous growth factors. This study aimed to evaluate the initial healing effects of PRP gel an...

  • Article
  • Open Access
7 Citations
2,523 Views
14 Pages

Anti-Reflective Zeolite Coating for Implantable Bioelectronic Devices

  • Giuseppe Oliva,
  • Maria Giovanna Bianco,
  • Antonino S. Fiorillo and
  • Salvatore A. Pullano

Since sunlight is one of the most easily available and clean energy supplies, solar cell development and the improvement of its conversion efficiency represent a highly interesting topic. Superficial light reflection is one of the limiting factors of...

  • Article
  • Open Access
11 Citations
4,989 Views
18 Pages

Molecular and Morphological Characterization of Exserohilum turcicum (Passerini) Leonard and Suggs Causing Northern Corn Leaf Blight of Maize in Bihar

  • Md Arshad Anwer,
  • Ram Niwas,
  • Tushar Ranjan,
  • Shyam Sundar Mandal,
  • Mohammad Ansar,
  • Jitendra Nath Srivastava,
  • Jitesh Kumar,
  • Khushbu Jain,
  • Neha Kumari and
  • Aditya Bharti

Maize is considered the third most important cereal crop in Asia after rice and wheat. Many diseases affect this crop due to the cultivation of various hybrids. This research aimed to characterize the causative agent of northern corn leaf blight dise...

  • Article
  • Open Access
13 Citations
4,376 Views
12 Pages

Subject-Based Model for Reconstructing Arterial Blood Pressure from Photoplethysmogram

  • Qunfeng Tang,
  • Zhencheng Chen,
  • Rabab Ward,
  • Carlo Menon and
  • Mohamed Elgendi

The continuous prediction of arterial blood pressure (ABP) waveforms via non-invasive methods is of great significance for the prevention and treatment of cardiovascular disease. Photoplethysmography (PPG) can be used to reconstruct ABP signals due t...

  • Article
  • Open Access
3 Citations
3,585 Views
22 Pages

Investigating the Transient Regenerative Potential of Cardiac Muscle Using a Neonatal Pig Partial Apical Resection Model

  • Katherine M. Copeland,
  • Bryn L. Brazile,
  • J. Ryan Butler,
  • Jim Cooley,
  • Erin Brinkman-Ferguson,
  • Andrew Claude,
  • Sallie Lin,
  • Sammira Rais-Rohani,
  • Bradley Welch and
  • Sara R. McMahan
  • + 7 authors

Researchers have shown that adult zebrafish have the potential to regenerate 20% of the ventricular muscle within two months of apex resection, and neonatal mice have the capacity to regenerate their heart after apex resection up until day 7 after bi...

  • Article
  • Open Access
14 Citations
3,183 Views
14 Pages

3D-printed hemipelvic endoprosthesis is an emerging solution for personalized limb-salvage reconstruction after periacetabular tumor resection. Further clinical studies are still required to report its surgical characteristics, outcomes, benefits and...

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Bioengineering - ISSN 2306-5354