Advancement in Cancer Research through 3D Tumor Modeling and Imaging System

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 3029

Special Issue Editors


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Guest Editor
Medical Laboratory Sciences and Public Health Department, Tarleton State University, Fort Worth, TX 76104, USA
Interests: 3D tumor models; cancer cell signatures; anticancer drug delivery systems; hydrogels; 3D bioprinting systems
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Guest Editor
Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, USA
Interests: medical imaging; ultrasound; MRI; multidimensional signal processing in the context of biomedical applications; the design and implementation of medical instruments; embedded systems in biomedical applications

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Guest Editor
Department of Bioengineering, University of Texas as Dallas, Richardson, TX 75080, USA
Interests: multiparametric ultrasound; image-guided focused ultrasound therapy; multifocused ultrasound therapy and tumor studies

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Guest Editor
Department of Clinical Immunology, Uniwersytet Jagielloński Collegium Medicum, Krakow, Poland
Interests: extracellular vesicles; cancer immunology and immunotherapy; biology of monocytes and macrophages; myeloid derived suppressor cells in cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ex vivo 3D scaffolding systems, tumoroids, and spheroids are commonly used 3D substrata for the study of various tumorigenesis. Different kinds of biomaterials with or without blended forms have been used and seen significant advances in the formation of tumor models that could mimic the natural microenvironment. A complex heterogeneity tumor which represents biological relevant tumors is not only necessary for tumor studies, for example, proliferation, growth, and cell signatures, but it is equally important to discover the efficacies of anticancer drugs. The implantation of 3D tumors into an animal is a common practice to generate xenograft tumors. Because of physiological and metabolic complexities, we cannot precisely monitor the growth of the tumor inside the animal, and there is always a challenge to trace the cell signatures that play a significant role in the tumor development. In addition, we do not have a complete set of physiological systems that actually resembles the in vivo tissue environment yet, and we therefore rely on the outcomes of animal studies. To understand the mechanism of tumor development in an animal, various techniques are emerging today, for example, in vivo imaging systems, H-scan ultrasound technologies, and various fluorescent dye-tagged cell technologies. The topics of interest of this Special Issue therefore include but are not limited to the following:

  • Advancements in 3D tumor systems, tumoroids, and spheroids;
  • Advancements in in vivo imaging systems to trace cells or molecules during tumor development, for example, their migration, involvement of tumor and protein expression;
  • Studies on cancer cell signatures in tissue mimicking the ex vivo environment and after implantation into an animal during xenograft development;
  • Development of innovative 3D substrata that could resemble biologically relevant conditions to the cells of interest;
  • Studies on different biomaterials, tumoroids or spheroids using innovative methodologies;
  • Study or design of any tissue heterogeneity or complexity for the cancer studies;
  • Application of ex vivo imaging systems to study ex vivo growing tumors.

Dr. Girdhari Rijal
Dr. Mawia Khairalseed
Dr. Lokesh Basavarajappa
Prof. Dr. Jarek Baran
Guest Editors

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Keywords

  • 3D tumor models
  • xenograft tumors
  • cancer cell signatures
  • H-scan ultrasound
  • in vivo imaging systems
  • dye-tagged cell technologies
  • scaffold
  • tumoroids
  • spheroids
  • anticancer drugs

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Published Papers (1 paper)

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14 pages, 2500 KiB  
Article
Computer-Aided Design and 3D Printing of Hemipelvic Endoprosthesis for Personalized Limb-Salvage Reconstruction after Periacetabular Tumor Resection
by Xianglin Hu, Yong Chen, Weiluo Cai, Mo Cheng, Wangjun Yan and Wending Huang
Bioengineering 2022, 9(8), 400; https://doi.org/10.3390/bioengineering9080400 - 18 Aug 2022
Cited by 9 | Viewed by 2425
Abstract
3D-printed hemipelvic endoprosthesis is an emerging solution for personalized limb-salvage reconstruction after periacetabular tumor resection. Further clinical studies are still required to report its surgical characteristics, outcomes, benefits and drawbacks. Sixteen consecutive patients underwent periacetabular tumor wide resection and pelvic reconstruction with a [...] Read more.
3D-printed hemipelvic endoprosthesis is an emerging solution for personalized limb-salvage reconstruction after periacetabular tumor resection. Further clinical studies are still required to report its surgical characteristics, outcomes, benefits and drawbacks. Sixteen consecutive patients underwent periacetabular tumor wide resection and pelvic reconstruction with a 3D-printed hemipelvic endoprosthesis from 2018 to 2021. The surgical characteristics and outcomes are described. The mean follow-up duration was 17.75 months (range, 6 to 46 months). Five patients underwent surgery for type I + II resection and reconstruction, seven for type II + III resection and reconstruction, three for type II resection and reconstruction, and one for type I + II + IV resection and reconstruction. The incidence of postoperative complication was 12.5% (2/16) for deep venous thrombosis (DVT), 12.5% (2/16) for pneumonia, and 12.5% (2/16) for would deep or superficial infection. During follow-up, two patients (12.5%) suffered hip dislocation and underwent revision surgery. CT demonstrated an obvious prosthetic porous structure–bone fusion after follow-up of at least 6 months. At the final follow-up, 12 lived with no evidence of disease while four lived with disease; no patients experienced pain; and 15 had independent ambulation, with a mean Musculoskeletal Tumor Society (MSTS) score of 85.8% (range, 26.7% to 100%). 3D-printed hemipelvic endoprosthesis facilitates wide resection of periacetabular tumor and limb-salvage reconstruction, thus resulting in good oncological and functional outcomes. The custom-made nature is able to well mimic the skeletal anatomy and microstructure and promote osseointegration. Perioperative complications and rehabilitation exercise still need to be stressed for this engineering technology-assisted major orthopedic surgery. Full article
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