Advancement in Cancer Research through 3D Tumor Modeling and Imaging System
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 3029
Special Issue Editors
Interests: 3D tumor models; cancer cell signatures; anticancer drug delivery systems; hydrogels; 3D bioprinting systems
Special Issues, Collections and Topics in MDPI journals
Interests: medical imaging; ultrasound; MRI; multidimensional signal processing in the context of biomedical applications; the design and implementation of medical instruments; embedded systems in biomedical applications
Interests: multiparametric ultrasound; image-guided focused ultrasound therapy; multifocused ultrasound therapy and tumor studies
Interests: extracellular vesicles; cancer immunology and immunotherapy; biology of monocytes and macrophages; myeloid derived suppressor cells in cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ex vivo 3D scaffolding systems, tumoroids, and spheroids are commonly used 3D substrata for the study of various tumorigenesis. Different kinds of biomaterials with or without blended forms have been used and seen significant advances in the formation of tumor models that could mimic the natural microenvironment. A complex heterogeneity tumor which represents biological relevant tumors is not only necessary for tumor studies, for example, proliferation, growth, and cell signatures, but it is equally important to discover the efficacies of anticancer drugs. The implantation of 3D tumors into an animal is a common practice to generate xenograft tumors. Because of physiological and metabolic complexities, we cannot precisely monitor the growth of the tumor inside the animal, and there is always a challenge to trace the cell signatures that play a significant role in the tumor development. In addition, we do not have a complete set of physiological systems that actually resembles the in vivo tissue environment yet, and we therefore rely on the outcomes of animal studies. To understand the mechanism of tumor development in an animal, various techniques are emerging today, for example, in vivo imaging systems, H-scan ultrasound technologies, and various fluorescent dye-tagged cell technologies. The topics of interest of this Special Issue therefore include but are not limited to the following:
- Advancements in 3D tumor systems, tumoroids, and spheroids;
- Advancements in in vivo imaging systems to trace cells or molecules during tumor development, for example, their migration, involvement of tumor and protein expression;
- Studies on cancer cell signatures in tissue mimicking the ex vivo environment and after implantation into an animal during xenograft development;
- Development of innovative 3D substrata that could resemble biologically relevant conditions to the cells of interest;
- Studies on different biomaterials, tumoroids or spheroids using innovative methodologies;
- Study or design of any tissue heterogeneity or complexity for the cancer studies;
- Application of ex vivo imaging systems to study ex vivo growing tumors.
Dr. Girdhari Rijal
Dr. Mawia Khairalseed
Dr. Lokesh Basavarajappa
Prof. Dr. Jarek Baran
Guest Editors
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Keywords
- 3D tumor models
- xenograft tumors
- cancer cell signatures
- H-scan ultrasound
- in vivo imaging systems
- dye-tagged cell technologies
- scaffold
- tumoroids
- spheroids
- anticancer drugs
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