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Medicines, Volume 5, Issue 2

2018 June - 34 articles

Cover Story: The Chumash people lived in the coastal region of Southern California for thousands of years before European explores arrived. Through generations of shared experience, the Chumash developed an extensive collection of practices using the diverse native plants species in this region as medicine. The woody shrub Trichostema lanatum Benth. View this paper. (Lamiaceae) is native to Southern California and was reportedly used by the Chumash people as a disinfectant and for the treatment of rheumatism. The report in this issue by Fleming et al. provides support for the traditional use of this plant as a medicine, demonstrating its antibacterial and anti-inflammatory properties. View this paper.
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Articles (34)

  • Article
  • Open Access
21 Citations
8,499 Views
16 Pages

Background: Cancer patients often take over-the-counter anti-oxidants as primary treatment or in combination with chemotherapy. Data about such use in glioblastoma is limited. Methods: Cultured U87-MG cells, a primary glioblastoma cell line (MU1454),...

  • Article
  • Open Access
5 Citations
6,296 Views
9 Pages

Effect of Different Dosages of ST36 Indirect Moxibustion on the Skin Temperature of the Lower Legs and Feet

  • Hiroshi Kuge,
  • Hidetoshi Mori,
  • Tateyuki Morisawa,
  • Kazuyo Hanyu,
  • Junji Miyazaki,
  • Mayumi Watanabe and
  • Tim Hideaki Tanaka

Background: Indirect moxibustion (IM) has been previously performed between the spinous process while recording skin temperature of the trunk. However, moxibustion is often applied not only to acupuncture points on the back, but also to points locate...

  • Protocol
  • Open Access
1 Citations
10,129 Views
16 Pages

Background: Anxiety and depression are conferring an increasing burden on society. Although treatments exist for both conditions, side effects, and difficulties accessing treatment prevent many people from receiving adequate assistance. Nutritional a...

  • Feature Paper
  • Article
  • Open Access
3,772 Views
8 Pages

Background: The effect of synchronous chemotherapy in squamous cell carcinoma of the head and neck (SCCHN) has been modelled as additional Biologically Effective Dose (BED) or as a prolonged tumour cell turnover time during accelerated repopulation....

  • Case Report
  • Open Access
1 Citations
5,896 Views
8 Pages

Use of Acupuncture in an Infant with Restlessness and Agitation

  • Katharina Murg,
  • Wolfgang Raith and
  • Berndt Urlesberger

Abstract: Background: We are reporting here about a 3-month-old boy with a history of failure to thrive, hypertrophic obstructive cardiomyopathy and neurological misbehaviour including hypotension in body muscles, who was found to have screaming atta...

  • Article
  • Open Access
18 Citations
5,962 Views
8 Pages

Background: According to recent studies, reactive oxygen is the leader of human metabolic disease development. The use of natural antioxidants is the best way to stop or prevent this problem. Therefore, the aim of this study was to evaluate the antio...

  • Feature Paper
  • Review
  • Open Access
16 Citations
7,324 Views
10 Pages

The Role of Cannabinoids in the Setting of Cirrhosis

  • Pratima Dibba,
  • Andrew A. Li,
  • George Cholankeril,
  • Umair Iqbal,
  • Chiranjeevi Gadiparthi,
  • Muhammad Ali Khan,
  • Donghee Kim and
  • Aijaz Ahmed

Although the mortality rates of cirrhosis are underestimated, its socioeconomic burden has demonstrated a significant global impact. Cirrhosis is defined by the disruption of normal liver architecture after years of chronic insult by different etiolo...

  • Feature Paper
  • Review
  • Open Access
31 Citations
7,055 Views
15 Pages

The increasing devolution of healthcare towards community care has meant that the management of many conditions is conducted within the home either by community nurses or by the patients themselves. The administration of medicines within home healthc...

  • Concept Paper
  • Open Access
7 Citations
8,505 Views
16 Pages

Accreditation Standard Guideline Initiative for Tai Chi and Qigong Instructors and Training Institutions

  • Byeongsang Oh,
  • Albert Yeung,
  • Penelope Klein,
  • Linda Larkey,
  • Carolyn Ee,
  • Chris Zaslawski,
  • Tish Knobf,
  • Peter Payne,
  • Elisabet Stener-Victorin and
  • David Rosenthal
  • + 15 authors

Evidence of the health and wellbeing benefits of Tai Chi and Qigong (TQ) have emerged in the past two decades, but TQ is underutilized in modern health care in Western countries due to lack of promotion and the availability of professionally qualifie...

  • Article
  • Open Access
3 Citations
4,350 Views
11 Pages

Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis

  • Paul Cos,
  • Jo Janssens,
  • Abel Piñón,
  • Osmany Cuesta-Rubio,
  • Arianna Yglesias-Rivera,
  • Alexis Díaz-García,
  • Wagner Vilegas and
  • Lianet Monzote

Background: Leishmaniasis is a complex protozoa disease caused by Leishmania genus (Trypanosomatidae family). Currently, there have been renewed interests worldwide in plants as pharmaceutical agents. In this study, the in vivo efficacy of Solanum sp...

  • Feature Paper
  • Review
  • Open Access
3 Citations
4,499 Views
15 Pages

Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System

  • Saritha Adepu,
  • Erik F. J. Oosterwerff,
  • Vincent M. Christoffels and
  • Gerard J. J. Boink

The regenerative medicine field has been revolutionized by the direct conversion of one cell type to another by ectopic expression of lineage-specific transcription factors. The direct reprogramming of fibroblasts to induced cardiac myocytes (iCMs) b...

  • Feature Paper
  • Review
  • Open Access
22 Citations
4,819 Views
9 Pages

Mechanistic Potential and Therapeutic Implications of Cannabinoids in Nonalcoholic Fatty Liver Disease

  • Pratima Dibba,
  • Andrew Li,
  • George Cholankeril,
  • Umair Iqbal,
  • Chiranjeevi Gadiparthi,
  • Muhammad Ali Khan,
  • Donghee Kim and
  • Aijaz Ahmed

Nonalcoholic fatty liver disease (NAFLD) is comprised of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). It is defined by histologic or radiographic evidence of steatosis in the absence of alternative etiologies, including si...

  • Review
  • Open Access
73 Citations
8,755 Views
16 Pages

Evaluation of the Pharmaceutical Properties and Value of Astragali Radix

  • Amy G. W. Gong,
  • Ran Duan,
  • Huai Y. Wang,
  • Xiang P. Kong,
  • Tina T. X. Dong,
  • Karl W. K. Tsim and
  • Kelvin Chan

Astragali Radix (AR), a Chinese materia medica (CMM) known as Huangqi, is an important medicine prescribed in herbal composite formulae (Fufang) by Traditional Chinese medicine (TCM) practitioners for thousands of years. According to the literature,...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,409 Views
12 Pages

In Vitro Iron Bioavailability of Brazilian Food-Based by-Products

  • Gabriela M. Chiocchetti,
  • Elisabete A. De Nadai Fernandes,
  • Anna A. Wawer,
  • Susan Fairweather-Tait and
  • Tatiana Christides

Background: Iron deficiency is a public health problem in many low- and middle-income countries. Introduction of agro-industrial food by-products, as additional source of nutrients, could help alleviate this micronutrient deficiency, provide alternat...

  • Article
  • Open Access
4 Citations
4,871 Views
13 Pages

Pharmacological Treatment for Long-Term Patients with Schizophrenia and Its Effects on Sleep in Daily Clinical Practice: A Pilot Study

  • Peggy Bosch,
  • Sabina Lim,
  • Heike Staudte,
  • Sujung Yeo,
  • Sook-Hyun Lee,
  • Pia Barisch,
  • Benoît Perriard and
  • Maurits Van den Noort

Background: Pharmacological treatment is still the key intervention in the disease management of long-term patients with schizophrenia; however, how it affects sleep and whether gender differences exist remains unclear. Methods: Forty-six long-term o...

  • Article
  • Open Access
8 Citations
5,279 Views
13 Pages

Background: Burkina Faso is classified among the countries with a high prevalence (˃12%) of hepatitis. Hepatic diseases, such as cirrhosis—related to alcoholism—and hepatitis B and C, are the cause of the increase in cases of liver cancer...

  • Article
  • Open Access
13 Citations
5,834 Views
8 Pages

Bibliometric Analysis of Traditional Chinese Medicine Scientific Production between 1982 and 2016 Indexed in PubMed

  • Ricardo Consentino,
  • Maria João Santos,
  • Luís Carlos Matos and
  • Jorge Pereira Machado

Background: Traditional Chinese medicine (TCM) may be understood as a system of sensations and findings designed to establish the functional vegetative state of the body. This state may be treated by several therapeutic methods such as acupuncture, C...

  • Perspective
  • Open Access
10 Citations
9,539 Views
9 Pages

Thirty years after the rise of the evidence-based medicine (EBM) movement, formal training in philosophy remains poorly represented among medical students and their educators. In this paper, I argue that EBM’s reception in this context has resu...

  • Review
  • Open Access
13 Citations
6,896 Views
10 Pages

Cardiovascular diseases (CVDs) have become prominent in mortality and morbidity rates. Prevalent cardiovascular conditions, such as hypertension, atherosclerosis and oxidative stress, are increasing at an alarming rate. Conventional drugs have been a...

  • Article
  • Open Access
31 Citations
11,221 Views
13 Pages

Background: Garlics and onions have been used for the treatment of diseases caused by parasites and microbes since ancient times. Trypanosomiasis and leishmaniasis are a concern in many areas of the world, especially in poor countries. Methods: Trypa...

  • Article
  • Open Access
9 Citations
5,355 Views
13 Pages

Antiproliferative and Antioxidant Activities of Two Extracts of the Plant Species Euphorbia dendroides L.

  • Agena Ghout,
  • Amar Zellagui,
  • Noureddine Gherraf,
  • Ibrahim Demirtas,
  • Yaglioglu Ayse Sahin,
  • Meriem Boukhenaf,
  • Mesbah Lahouel,
  • Gema Nieto and
  • Salah Akkal

Background: These days, the desire for naturally occurring antioxidants has significantly increased, especially for use in foodstuffs, cosmetics, and pharmaceutical products, to replace synthetic antioxidants that are regularly constrained due to the...

  • Review
  • Open Access
11 Citations
9,134 Views
11 Pages

A Review of Evidence for a Therapeutic Application of Traditional Japanese Kampo Medicine for Oral Diseases/Disorders

  • Marie-Pier Veilleux,
  • Satomi Moriyama,
  • Masami Yoshioka,
  • Daisuke Hinode and
  • Daniel Grenier

Kampo medicines prescribed by specialized medical practitioners and Japanese physicians have gradually reemerged in Japan as alternatives to Western medications. Kampo formulations are composed of several plant extracts and, as such, the broad variet...

  • Article
  • Open Access
10 Citations
6,267 Views
15 Pages

Beneficial Effect of Ocimum sanctum (Linn) against Monocrotaline-Induced Pulmonary Hypertension in Rats

  • Himanshu Meghwani,
  • Pankaj Prabhakar,
  • Soheb A. Mohammed,
  • Pamila Dua,
  • Sandeep Seth,
  • Milind P. Hote,
  • Sanjay K. Banerjee,
  • Sudheer Arava,
  • Ruma Ray and
  • Subir Kumar Maulik

Background: The study was designed to explore any beneficial effect of Ocimum sanctum (Linn) (OS) in experimental pulmonary hypertension (PH) in rats. OS is commonly known as “holy basil” and “Tulsi” and is used in the Indian...

  • Feature Paper
  • Article
  • Open Access
82 Citations
8,649 Views
9 Pages

Background: Natural antioxidants, which can replace synthetic ones due to their potential implications for health problems in children, have gained significant popularity. Therefore, the antioxidant potential of extracts obtained from three brown mac...

  • Feature Paper
  • Article
  • Open Access
4 Citations
5,748 Views
9 Pages

Background: Magnetic resonance (MR)-fusion contouring is the standard of care in prostate stereotactic body radiotherapy (SBRT) for target volume localisation. However, the planning computerised tomography (CT) scan continues to be used for dose calc...

  • Feature Paper
  • Review
  • Open Access
9 Citations
10,347 Views
14 Pages

Acupuncture as Add-On Treatment of the Positive, Negative, and Cognitive Symptoms of Patients with Schizophrenia: A Systematic Review

  • Maurits Van den Noort,
  • Sujung Yeo,
  • Sabina Lim,
  • Sook-Hyun Lee,
  • Heike Staudte and
  • Peggy Bosch

Background: Schizophrenia is a severe psychiatric disorder that has a large impact on patients’ lives. In addition to Western medicine, the use of additional treatments, such as acupuncture, in treating the positive, negative, and cognitive symptoms...

  • Article
  • Open Access
11 Citations
8,152 Views
16 Pages

Biopsychosocial Assessment of Pain with Thermal Imaging of Emotional Facial Expression in Breast Cancer Survivors

  • David Alberto Rodríguez Medina,
  • Benjamín Domínguez Trejo,
  • Patricia Cortés Esteban,
  • Irving Armando Cruz Albarrán,
  • Luis Alberto Morales Hernández and
  • Gerardo Leija Alva

Background: Recent research has evaluated psychological and biological characteristics associated with pain in survivors of breast cancer (BC). Few studies consider their relationship with inflammatory activity. Voluntary facial expressions modify th...

  • Feature Paper
  • Review
  • Open Access
15 Citations
5,160 Views
12 Pages

Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease

  • Fumihiro Sanada,
  • Yoshiaki Taniyama,
  • Jun Muratsu,
  • Rei Otsu,
  • Hideo Shimizu,
  • Hiromi Rakugi and
  • Ryuichi Morishita

The World Health Organization announced that cardiovascular disease is the number one cause of death globally, representing 31% of all global deaths. Coronary artery disease (CAD) affects approximately 5% of the US population aged 40 years and older....

  • Hypothesis
  • Open Access
1 Citations
6,471 Views
18 Pages

Background: Benveniste’s biology experiments suggested the existence of molecular-like effects without molecules (“memory of water”). In this article, it is proposed that these disputed experiments could have been the consequence of a previously unno...

  • Review
  • Open Access
10 Citations
7,379 Views
11 Pages

Genetic Variations Associated with Sleep Disorders in Patients with Schizophrenia: A Systematic Review

  • Konstantinos Assimakopoulos,
  • Katerina Karaivazoglou,
  • Maria Skokou,
  • Marina Kalogeropoulou,
  • Panagiotis Kolios,
  • Philippos Gourzis,
  • George P. Patrinos and
  • Evangelia Eirini Tsermpini

Background: Schizophrenic patients commonly suffer from sleep disorders which are associated with acute disease severity, worsening prognoses and a poorer quality of life. Research is attempting to disentangle the complex interplay between schizophre...

  • Article
  • Open Access
37 Citations
6,007 Views
10 Pages

Background: Capnophyllum peregrinum (L.) Lange (Apiaceae) is the unique taxon of capnophyllum genus in Algerian flora. It has never been investigated in regards to its total phenolic and flavonoid contents and antioxidant and photoprotective activiti...

  • Article
  • Open Access
1 Citations
5,762 Views
8 Pages

Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum

  • Matthew C. Fleming,
  • Victoria Hester,
  • Brittany J. Allison,
  • Majie C. Foster,
  • Donna Nofziger and
  • P. Matthew Joyner

Background: The woody shrub Trichostema lanatum Benth. (Lamiaceae) is native to Southern California and was reportedly used by the Chumash people as a disinfectant and for the treatment of rheumatism. Based on its traditional uses, this study investi...

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Medicines - ISSN 2305-6320