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Medicines 2018, 5(2), 36; https://doi.org/10.3390/medicines5020036

Antiproliferative and Antioxidant Activities of Two Extracts of the Plant Species Euphorbia dendroides L.

1
Laboratory of Biomolecules and Plant Breeding, Life Science and Nature Department, Faculty of Exact Science and Life Science and Nature, University of Larbi Ben Mhidi, Oum El Bouaghi 04000, Algeria
2
Department of Chemistry, Faculty of Exact Science and Life Science and Nature, University of Larbi Ben, Mhidi Oum El Bouaghi 04000, Algeria
3
Laboratory of Plant Research, Department of Chemistry, Faculty of Science, Uluyazi Campus, Cankiri Karatekin University, Cankiri 18100, Turkey
4
Department of Pathological Anatomy, University Hospital Center of Constantine, Constantine 25000, Algeria
5
Laboratory of Molecular Toxicology, University of Jijel, Jijel 18000, Algeria
6
Department of Food Technology, Nutrition and Food Science, Faculty of Veterinary Sciences, University of Murcia, Campus de Espinardo, Espinardo, Murcia 30100, Spain
7
Laboratoire de Phytochimie et Analyses Physico-Chimiques et Biologiques, Université Mentouri de Constantine, Route de Aïn El Bey, Constantine 25000, Algeria
*
Author to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 10 April 2018 / Accepted: 13 April 2018 / Published: 20 April 2018
(This article belongs to the Special Issue Medicinal Plants and Foods)
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Abstract

Background: These days, the desire for naturally occurring antioxidants has significantly increased, especially for use in foodstuffs, cosmetics, and pharmaceutical products, to replace synthetic antioxidants that are regularly constrained due to their carcinogenicity. Methods: The study in hand aimed to appraise the antioxidant effect of two Euphorbia dendroides extracts using reducing power, anti-peroxidation, and DPPH (1,1 Diphenyl 2 Pycril Hydrazil) scavenging essays, in addition to the anticancer activity against two tumor cell lines, namely C6 (rat brain tumor)cells, and Hela (human uterus carcinoma)cell lines. Results: The results indicated that the ethyl acetate extract exhibited antiradical activity of 29.49%, higher than that of n-butanol extract (18.06%) at 100 µg/mL but much lower than that of gallic acid (78.21%).The ethyl acetate extract exhibits better reducing capacity and lipid peroxidation inhibitory activity compared to n-butanol extract but less than all tested standards. Moreover, the ethyl acetate extract was found to have an antiproliferative activity of more than 5-FU (5-fluoro-Uracil) against C6 cells at 250 µg/mL with IC50 and IC75 of 113.97, 119.49 µg/mL, respectively, and good cytotoxic activity against the Hela cell lines at the same concentration. The HPLC-TOF-MS (high performance liquid chromatography-Time-of-flight-Mass Spectrometry) analyses exposed the presence of various compounds, among which Gallic and Chlorogenic acids functioned as major compounds. Conclusions: The two extracts exhibited moderate anticancer abilities and behaved somewhat as average antioxidant agents. Based on the total phenolics and flavonoids contents, as well as HPLC results, it could be concluded that antiproliferative and antioxidant activities depend upon the content of different phenolics and flavonoids. View Full-Text
Keywords: Euphorbia dendroides; phenolic compounds; HPLC; antioxidant activity; antiproliferative activity Euphorbia dendroides; phenolic compounds; HPLC; antioxidant activity; antiproliferative activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ghout, A.; Zellagui, A.; Gherraf, N.; Demirtas, I.; Ayse Sahin, Y.; Boukhenaf, M.; Lahouel, M.; Nieto, G.; Akkal, S. Antiproliferative and Antioxidant Activities of Two Extracts of the Plant Species Euphorbia dendroides L.. Medicines 2018, 5, 36.

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