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Article

Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum

Natural Science Division, Pepperdine University, 24255 Pacific Coast Highway, Malibu, CA 90263, USA
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Medicines 2018, 5(2), 25; https://doi.org/10.3390/medicines5020025
Received: 20 February 2018 / Revised: 12 March 2018 / Accepted: 18 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Bioactivities and Medical Use of Herbs and Plants)
Background: The woody shrub Trichostema lanatum Benth. (Lamiaceae) is native to Southern California and was reportedly used by the Chumash people as a disinfectant and for the treatment of rheumatism. Based on its traditional uses, this study investigated the antibacterial and immunomodulatory properties of extracts from T. lanatum. Methods: A methanolic extract of the leaves and stems of T. lanatum was tested for immunomodulatory activity by measuring the proliferation of murine macrophage cell cultures and the production of the pro-inflammatory cytokine TNF-α by the cells after treatment with T. lanatum. Antibacterial activity of the extract against a panel of six Gram-positive bacteria and two Gram-negative bacteria was evaluated using a disc-diffusion assay. Results: The T. lanatum extract inhibited the growth of Gram-positive bacteria, but not Gram-negative bacteria. Treatment of activated macrophage cell cultures with T. lanatum extract resulted in decreased proliferation of the activated macrophages and a decrease in the production of TNF-α. Conclusions: These results provide the first pharmacological support for the traditional use of T. lanatum by the Chumash people of Southern California as a disinfectant and treatment for rheumatism. View Full-Text
Keywords: Trichostema lanatum; immunomodulatory; antibacterial; macrophage; TNF-α; traditional medicines of North America Trichostema lanatum; immunomodulatory; antibacterial; macrophage; TNF-α; traditional medicines of North America
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MDPI and ACS Style

Fleming, M.C.; Hester, V.; Allison, B.J.; Foster, M.C.; Nofziger, D.; Joyner, P.M. Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum. Medicines 2018, 5, 25. https://doi.org/10.3390/medicines5020025

AMA Style

Fleming MC, Hester V, Allison BJ, Foster MC, Nofziger D, Joyner PM. Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum. Medicines. 2018; 5(2):25. https://doi.org/10.3390/medicines5020025

Chicago/Turabian Style

Fleming, Matthew C., Victoria Hester, Brittany J. Allison, Majie C. Foster, Donna Nofziger, and P. Matthew Joyner. 2018. "Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum" Medicines 5, no. 2: 25. https://doi.org/10.3390/medicines5020025

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