Next Article in Journal
In Vitro Assessment of Total Phenolic and Flavonoid Contents, Antioxidant and Photoprotective Activities of Crude Methanolic Extract of Aerial Parts of Capnophyllum peregrinum (L.) Lange (Apiaceae) Growing in Algeria
Next Article in Special Issue
Beneficial Effect of Ocimum sanctum (Linn) against Monocrotaline-Induced Pulmonary Hypertension in Rats
Previous Article in Journal
Gender Differences in Laser Acupuncture—Results of a Crossover Study with Green and Yellow Laser at the Ear Point Shenmen
Previous Article in Special Issue
Dental Application of Natural Products
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessArticle
Medicines 2018, 5(2), 25; https://doi.org/10.3390/medicines5020025

Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum

Natural Science Division, Pepperdine University, 24255 Pacific Coast Highway, Malibu, CA 90263, USA
*
Author to whom correspondence should be addressed.
Received: 20 February 2018 / Revised: 12 March 2018 / Accepted: 18 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Bioactivities and Medical Use of Herbs and Plants)
Full-Text   |   PDF [953 KB, uploaded 3 May 2018]   |  

Abstract

Background: The woody shrub Trichostema lanatum Benth. (Lamiaceae) is native to Southern California and was reportedly used by the Chumash people as a disinfectant and for the treatment of rheumatism. Based on its traditional uses, this study investigated the antibacterial and immunomodulatory properties of extracts from T. lanatum. Methods: A methanolic extract of the leaves and stems of T. lanatum was tested for immunomodulatory activity by measuring the proliferation of murine macrophage cell cultures and the production of the pro-inflammatory cytokine TNF-α by the cells after treatment with T. lanatum. Antibacterial activity of the extract against a panel of six Gram-positive bacteria and two Gram-negative bacteria was evaluated using a disc-diffusion assay. Results: The T. lanatum extract inhibited the growth of Gram-positive bacteria, but not Gram-negative bacteria. Treatment of activated macrophage cell cultures with T. lanatum extract resulted in decreased proliferation of the activated macrophages and a decrease in the production of TNF-α. Conclusions: These results provide the first pharmacological support for the traditional use of T. lanatum by the Chumash people of Southern California as a disinfectant and treatment for rheumatism. View Full-Text
Keywords: Trichostema lanatum; immunomodulatory; antibacterial; macrophage; TNF-α; traditional medicines of North America Trichostema lanatum; immunomodulatory; antibacterial; macrophage; TNF-α; traditional medicines of North America
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Fleming, M.C.; Hester, V.; Allison, B.J.; Foster, M.C.; Nofziger, D.; Joyner, P.M. Immunomodulatory and Antibacterial Properties of the Chumash Medicinal Plant Trichostema lanatum. Medicines 2018, 5, 25.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicines EISSN 2305-6320 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top