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Children, Volume 12, Issue 11

November 2025 - 153 articles

Cover Story: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are reshaping pediatric obesity and type 2 diabetes management, with approved products offering significant BMI and weight reductions. However, major knowledge gaps remain. Long-term safety and durability of effect in youth are unknown, particularly regarding bone health, lean mass preservation, and neurohormonal development. Optimal dosing, duration, and criteria for treatment discontinuation risk for weight rebound require further study. This review integrates clinical and mechanistic evidence while underscoring the urgent need for longitudinal, pediatric-specific research to inform safe and effective obesity pharmacotherapy in growing children. View this paper
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Articles (153)

  • Article
  • Open Access
360 Views
15 Pages

The Edmonton Obesity Staging System for Pediatrics (EOSS-P) in Mexican Children and Adolescents Living with Obesity: Beyond BMI Obesity Classes

  • Isabel Omaña-Guzmán,
  • Roberto Carlos Rodríguez Quintero,
  • Arturo Ruíz-Arroyo,
  • Edith Prado Díaz,
  • Juan Carlos López-Alvarenga,
  • Ana María Hernández López,
  • Zendy Fuentes Corona,
  • Karina Aguilar Cuarto,
  • Karen Pedraza Escudero and
  • Alejandra Ruíz Barranco
  • + 2 authors

17 November 2025

Background/Objectives: The Edmonton Obesity Staging System (EOSS) was developed to stage the obesity in adult populations. Subsequently, this staging system was designed for pediatric populations (EOSS-P). This study aimed to describe obesity severit...

  • Article
  • Open Access
339 Views
10 Pages

17 November 2025

Objective: To compare the efficacy of endoscopic retrograde cholangiopancreatography (ERCP) and the Frey procedure in the treatment of pediatric pancreatic duct stones (PDS). Methods: A retrospective analysis was conducted on 65 pediatric patients tr...

  • Article
  • Open Access
574 Views
18 Pages

Injectable Hyaluronic Acid and Amino Acids Complex for Pediatric Hard-to-Heal Wounds: A Prospective Case Series and Therapeutic Protocol

  • Guido Ciprandi,
  • Biagio Nicolosi,
  • Gabriele Storti,
  • Simone F. Marino,
  • Carlotta Scarpa and
  • Franco Bassetto

17 November 2025

Background: Pediatric hard-to-heal wounds are rare but clinically demanding due to skin immaturity, comorbidities, and infection risk. Methods: This prospective case series evaluated the feasibility, safety, and clinical outcomes of an injectable hya...

  • Article
  • Open Access
285 Views
13 Pages

Effect of Abdominal Adiposity on the Impact of Plantar Force in the Foot Support of Obese and Overweight Schoolchildren

  • Ana Paula Ribeiro,
  • Daniel Borges Pereira,
  • Gabrielle Fontura Berger,
  • Kemely Muraiber Ismail,
  • Maitê Duarte Morais and
  • Mayara Slaiman Fares Martins

17 November 2025

Background: Childhood obesity is a growing global concern associated with early-onset orthopedic complications that may persist into adulthood. Among the anthropometric indicators, abdominal adiposity plays a key role in assessing health risks during...

  • Article
  • Open Access
304 Views
19 Pages

Subtalar Arthroereisis with Calcaneus Stop Screws—Can the Angles on Pre- and Post-Surgical X-Ray Images Be Reliably Measured by Artificial Intelligence?

  • Lea Alexandra Simmler,
  • Monika Herten,
  • Samuel Hohenberger,
  • Cedric Rubenthaler,
  • Heinz-Lothar Meyer,
  • Bastian Mester,
  • Stephanie Herbstreit,
  • Johannes Haubold,
  • Manuel Burggraf and
  • Marcel Dudda
  • + 1 author

17 November 2025

Background/Objectives: Flexible symptomatic flat foot in children can be surgically treated with calcaneus stop screws. This raises the question of whether pre- and postoperative radiographs (X-ray) can be analyzed in two planes using AI. Methods: In...

  • Article
  • Open Access
301 Views
12 Pages

17 November 2025

Background/Objectives: This randomized, single-blinded trial compared the effects of Kinesio taping (KT) and rigid taping (RT) on gross motor function, balance, and functional capacity in children with hemiplegic cerebral palsy (HCP). Methods: Fifty-...

  • Review
  • Open Access
926 Views
19 Pages

Small Intestinal Bacterial Overgrowth in Children with Short Bowel Syndrome

  • Hannah DeGonza,
  • Thu Anh Pham,
  • Rasha Elmaoued,
  • Razan Alkhouri,
  • Ricardo Orlando Castillo and
  • Rajmohan Dharmaraj

16 November 2025

Small Intestinal Bacterial Overgrowth (SIBO) is characterized by an abnormal proliferation of bacteria in the small intestine, leading to gastrointestinal symptoms and nutritional deficiencies. Short Bowel Syndrome (SBS), resulting from extensive sur...

  • Systematic Review
  • Open Access
230 Views
37 Pages

Acid–Base Status and Cerebral Oxygenation in Neonates: A Systematic Qualitative Review of the Literature

  • Christian Mattersberger,
  • Bernhard Schwaberger,
  • Nariae Baik-Schneditz and
  • Gerhard Pichler

16 November 2025

Introduction: Blood gas analysis is utilized to assess parameters of oxygenation and ventilation, including acid–base status [pH value, base excess (BE) or base deficit (BD), and bicarbonate (HCO3)], to evaluate systemic metabolism status. Acid...

  • Article
  • Open Access
323 Views
12 Pages

Facilitators and Barriers to the Implementation of Family Integrated Care in Ontario Level II Neonatal Intensive Care Units

  • Ayah Al Bizri,
  • Mariana Bueno,
  • Vibhuti Shah,
  • Fabiana Bacchini,
  • Douglas M. Campbell,
  • Karen M. Benzies and
  • Karel O’Brien

16 November 2025

Background/Objectives: In Ontario, approximately 8% (11,000) of infants are born preterm (22–<37 weeks gestation) each year. Many of these infants are cared for in a Level II Neonatal Intensive Care Unit (NICU). Family Integrated Care (FICar...

  • Article
  • Open Access
306 Views
10 Pages

15 November 2025

Background: The COVID-19 pandemic has been associated with increased sedentary behavior in children, raising concerns about posture and spinal health. This study compared standardized measures of sitting spinal alignment in two independent cohorts as...

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Children - ISSN 2227-9067