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Children
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Advances in Pediatric Gastroenterology (2nd Edition)
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Advances in Pediatric Gastroenterology (2nd Edition)

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Gastroenterology and Nutrition".

Deadline for manuscript submissions: 25 January 2026 | Viewed by 853

Special Issue Editors

Dr. Rajmohan Dharmaraj

E-Mail Website
Guest Editor
Division of Gastroenterology, Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131, USA
Interests: inflammatory bowel disease; pediatric nutrition; endoscopic procedures
Special Issues, Collections and Topics in MDPI journals
Dr. Razan H. Alkhouri

E-Mail Website
Guest Editor
Division of Gastroenterology, Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131, USA
Interests: inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Last year, we successfully proposed a Special Issue on “Advances in Pediatric Gastroenterology”. We are excited to invite you to contribute to the second edition of this Special Issue titled “Advances in Pediatric Gastroenterology.”

The field of pediatric gastroenterology is continually evolving. Pediatric patients face a wide range of gastrointestinal and liver diseases, varying from asymptomatic or mild conditions to severe and potentially life-threatening issues. In recent years, significant advancements have been made in basic science research, diagnostics, and treatment related to pediatric gastroenterology. However, many gaps still exist in our understanding of the pathogenesis, diagnostics, and management of these diseases.

This Special Issue of Children aims to gather and publish original research articles and reviews that highlight recent advances in these areas of pediatric gastroenterology. Given your expertise in this field, we are pleased to invite you to contribute to the upcoming Special Issue.

We look forward to receiving your contributions.

Dr. Rajmohan Dharmaraj
Dr. Razan H. Alkhouri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • celiac disease
  • functional gastrointestinal disorders (disorders of gut–brain interaction)
  • gastroesophageal reflux disease
  • eosinophilic gastrointestinal diseases
  • food allergies
  • nutritional disorders
  • liver diseases in children

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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12 pages, 747 KB  
Article
Diagnostic Value of Leukocyte Count, C-Reactive Protein, and Procalcitonin in Pediatric Liver Transplant Patients During the First Week Postoperative: A Longitudinal Study from a Tertiary Center and a New Diagnostic Method for Predicting Systemic Infection
by Zerrin Onal, Elif Turkmen, Demet Demirkol, Ugur Can Leblebici, Ibrahim Kandemir, Tugce Goksu Yilmaz, Selda Hancerli Torun, Feza Ekiz, Ilgin Ozden and Ozlem Durmaz
Children 2025, 12(9), 1201; https://doi.org/10.3390/children12091201 - 9 Sep 2025
Viewed by 294
Abstract
Background/Objectives: Infection is a major complication during the early postoperative period following pediatric liver transplantation (LT). Prompt diagnosis and treatment are essential to prevent death. We aimed to assess the diagnostic value of procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein [...] Read more.
Background/Objectives: Infection is a major complication during the early postoperative period following pediatric liver transplantation (LT). Prompt diagnosis and treatment are essential to prevent death. We aimed to assess the diagnostic value of procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein (CRP) levels for detecting bacterial infection and SIRS within the first week after LT. Methods: Demographic data, vital signs, laboratory results (PCT, CRP, WBC), and culture findings on the 1st, 4th, and 7th days between January 2010 and 2024 were collected retrospectively. Results: The study included 88 patients. Seventy-two percent had cirrhotic liver disease. SIRS was present in 17% (n = 15), and bacterial growth was detected in 20% (n = 18). Bacterial growth was found in 80% of patients with SIRS (n = 12/15) and in 8% of SIRS-negative patients (n = 6/73). PCT levels were significantly elevated on days 1, 4, and 7, and CRP levels on days 4 and 7 in patients with SIRS. PCT elevation was significant on days 1, 4, and 7, while WBC increase was noted on day 7 in patients with bacterial growth. Body temperature ≥ 37.1 °C and PCT ≥ 5.1 ng/dL on the first day together showed a sensitivity of 72.2% and specificity of 84.3% for bacterial growth. Similarly, body temperature ≥ 37.1 °C and PCT ≥ 9.2 ng/dL on the first day yielded 73% sensitivity and 95% specificity for diagnosing SIRS. Cirrhotic patients exhibited limited or no WBC response to bacterial growth. Conclusions: PCT, CRP, and WBC alone are insufficient for diagnosing infection. Combined assessment of body temperature changes and PCT elevation may serve as more accurate indicators. Nonetheless, close monitoring of culture results and clinical signs, with serial physical exams, can aid timely infection management or prevent unnecessary antibiotic adjustments. Full article
(This article belongs to the Special Issue Advances in Pediatric Gastroenterology (2nd Edition))
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9 pages, 2008 KB  
Case Report
Efficacy of Modified Upadacitinib Dosing in Pediatric Refractory IBD: A Case-Based Analysis
by Frank Risto Rommel, Christa Bergheim, Inga Jerrentrup, Stefanie Weber and Andreas Jenke
Children 2025, 12(9), 1268; https://doi.org/10.3390/children12091268 - 21 Sep 2025
Viewed by 210
Abstract
This case report describes four pediatric patients with severe, therapy-refractory ulcerative colitis (UC) and one pediatric patient with severe, therapy-refractory Crohn’s disease (CD), all of whom failed widely used biologic therapies, including the approved treatments infliximab and adalimumab, as well as off-label use [...] Read more.
This case report describes four pediatric patients with severe, therapy-refractory ulcerative colitis (UC) and one pediatric patient with severe, therapy-refractory Crohn’s disease (CD), all of whom failed widely used biologic therapies, including the approved treatments infliximab and adalimumab, as well as off-label use of vedolizumab and ustekinumab. Despite these first- and second-line interventions, patients’ diseases remained active. Following the initiation of upadacitinib, an off-label Janus kinase (JAK) inhibitor with positive results in adult UC and CD patients, four children experienced rapid symptom improvement and achieved clinical remission. The rising incidence of pediatric inflammatory bowel disease (IBD) and the limited number of approved therapies underscore the need for additional treatment options in pediatric gastroenterology. Infliximab remains one of the only biologic therapies approved for pediatric UC and CD, forcing clinicians to rely on off-label medications, such as vedolizumab, ustekinumab, and upadacitinib, when standard treatments fail. To address this gap, it is crucial to include pediatric patients in clinical trials of new therapies, expanding the range of approved medications and improving outcomes for children with IBD. Full article
(This article belongs to the Special Issue Advances in Pediatric Gastroenterology (2nd Edition))
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