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Biomedicines, Volume 11, Issue 8

August 2023 - 241 articles

Cover Story: The delivery of drugs to the central nervous system after Intranasal administration can often be accompanied by difficulties due to the specific physicochemical properties of biomolecules (e.g., molecular weight, solubility, stability), or by a physiological barrier (mucociliary clearance). Strategies adopted include combining micro- and nanotechnologies and using excipients that extend the nasal residence time. Additionally, nasal delivery requires a device to adequately deliver the formulation to the required area of the nasal cavity. The experimental models allow for extensive preclinical investigation of the administered drug, which will be further used to correlate the brain-targeting potential of intranasal administration in humans. View this paper
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Articles (241)

  • Review
  • Open Access
3 Citations
6,778 Views
25 Pages

Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. The dystrophin gene is the largest gene and has a key role in skeletal muscle construction and function. Mutations in the dystrophin gen...

  • Article
  • Open Access
9 Citations
3,600 Views
19 Pages

Pre-eclampsia (PE) is a gestational hypertensive disorder that is characterized by hypertension and proteinuria, typically occurring after 20 weeks of gestation. Despite its global impact on pregnant women, the precise pathogenic mechanisms of PE rem...

  • Article
  • Open Access
5 Citations
3,623 Views
14 Pages

The Role of Mesenchymal Stem Cell Secretome in the Inflammatory Mediators and the Survival Rate of Rat Model of Sepsis

  • Mutiara Indah Sari,
  • Nelva Karmila Jusuf,
  • Delfitri Munir,
  • Agung Putra,
  • Tatang Bisri,
  • Syafruddin Ilyas,
  • Farhat Farhat,
  • Adi Muradi Muhar,
  • Muhammad Rusda and
  • Mustafa Mahmud Amin

In sepsis, simultaneously elevated levels of pro-inflammatory cytokines and interleukin (IL)-10 indicate immune response dysregulation, increasing the mortality of the host. As mesenchymal stem cell (MSC) secretome is known to have immunomodulatory e...

  • Article
  • Open Access
7 Citations
2,621 Views
10 Pages

MALDI-TOF MS Analysis of Serum Peptidome Patterns in Cervical Cancer

  • Phetploy Rungkamoltip,
  • Sittiruk Roytrakul and
  • Raphatphorn Navakanitworakul

Background: Cervical cancer is the fourth most common cancer among females worldwide. Identifying peptide patterns discriminating healthy individuals from those with diseases has gained interest in the early detection of cancers. Our study aimed to d...

  • Case Report
  • Open Access
1 Citations
2,474 Views
10 Pages

Ampullary adenocarcinoma is a rare malignancy that lacks standard systemic treatment. We describe a case of recurrent metastatic ampullary adenocarcinoma of the pancreaticobiliary subtype treated with nanoparticle albumin-bound (nab)-paclitaxel and g...

  • Review
  • Open Access
3 Citations
2,859 Views
15 Pages

Refining Liver Biopsy in Hepatocellular Carcinoma: An In-Depth Exploration of Shifting Diagnostic and Therapeutic Applications

  • Zeno Spârchez,
  • Rareș Crăciun,
  • Iuliana Nenu,
  • Lavinia Patricia Mocan,
  • Mihaela Spârchez and
  • Tudor Mocan

The field of hepatocellular carcinoma (HCC) has faced significant change on multiple levels in the past few years. The increasing emphasis on the various HCC phenotypes and the emergence of novel, specific therapies have slowly paved the way for a pe...

  • Review
  • Open Access
37 Citations
10,092 Views
25 Pages

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

  • Catalina Christensen,
  • Martin Rose,
  • Claus Cornett and
  • Morten Allesø

The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid. As a hypothetical afterthought, this was proposed to hold ge...

  • Article
  • Open Access
2 Citations
2,254 Views
16 Pages

Apocynin, an NADPH Oxidase Enzyme Inhibitor, Prevents Amebic Liver Abscess in Hamster

  • Germán Higuera-Martínez,
  • Ivonne Maciel Arciniega-Martínez,
  • Rosa Adriana Jarillo-Luna,
  • Luz María Cárdenas-Jaramillo,
  • David Levaro-Loquio,
  • Maritza Velásquez-Torres,
  • Edgar Abarca-Rojano,
  • Aldo Arturo Reséndiz-Albor and
  • Judith Pacheco-Yépez

Amebiasis is an intestinal infection caused by Entamoeba histolytica. Amebic liver abscess (ALA) is the most common extraintestinal complication of amebiasis. In animal models of ALA, neutrophils have been shown to be the first cells to come into con...

  • Article
  • Open Access
20 Citations
6,996 Views
15 Pages

High-frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (L-DLPFC) shows promise as a treatment for treatment-resistant depression in adolescents. Conventional rTMS coil placement strategies includ...

  • Article
  • Open Access
11 Citations
6,069 Views
11 Pages

Induction of Skin Cancer by Long-Term Blue Light Irradiation

  • Keiichi Hiramoto,
  • Sayaka Kubo,
  • Keiko Tsuji,
  • Daijiro Sugiyama and
  • Hideo Hamano

Presently, people are not only exposed to sunlight but also to a large amount of blue light from personal computers and smartphones. This blue light has various effects on the living body. However, its effect on the induction of skin cancer is unknow...

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Biomedicines - ISSN 2227-9059