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Biomedicines, Volume 11, Issue 8

August 2023 - 241 articles

Cover Story: The delivery of drugs to the central nervous system after Intranasal administration can often be accompanied by difficulties due to the specific physicochemical properties of biomolecules (e.g., molecular weight, solubility, stability), or by a physiological barrier (mucociliary clearance). Strategies adopted include combining micro- and nanotechnologies and using excipients that extend the nasal residence time. Additionally, nasal delivery requires a device to adequately deliver the formulation to the required area of the nasal cavity. The experimental models allow for extensive preclinical investigation of the administered drug, which will be further used to correlate the brain-targeting potential of intranasal administration in humans. View this paper
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Articles (241)

  • Article
  • Open Access
4 Citations
2,581 Views
18 Pages

The Expression Characteristics and Function of the RECQ Family in Pan-Cancer

  • Yuanyuan Zhou,
  • Xucheng Huang,
  • Liya Wang and
  • Yujia Luo

Background: The genes of the RECQ DNA helicase family play a part in preserving the stability of the genome and controlling different disease mechanisms. However, the expression features of RECQs in relation to pan-cancer, their correlation with the...

  • Article
  • Open Access
2 Citations
3,300 Views
12 Pages

Sensory Modulation Abilities in Healthy Preterm-Born Children: An Observational Study Using the Sensory Processing and Self-Regulation Checklist (SPSRC)

  • Giulia Previtali,
  • Cynthia Y. Y. Lai,
  • Maria Valvassori Bolgè,
  • Anna Cavallini,
  • Renata Nacinovich,
  • Daniele Piscitelli and
  • Giulia Purpura

This study aimed to investigate prematurity as a risk factor for sensory processing disorders, using the Italian Version of Sensory Processing and Self-Regulation Checklist (SPSRC-IT), based on a sample of healthy Italian children born preterm in com...

  • Article
  • Open Access
2 Citations
1,613 Views
12 Pages

Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells

  • Jun Ito,
  • Shigeki Sugawara,
  • Takeo Tatsuta,
  • Masahiro Hosono and
  • Makoto Sato

Metastatic renal cell carcinoma (RCC) is not sufficiently responsive to anticancer drugs, and thus, developing new drugs for advanced RCC remains vital. We previously reported that the treatment of globotriaosylceramide (Gb3)-expressing cells with ca...

  • Article
  • Open Access
1,896 Views
15 Pages

Accurate pharmacokinetic–pharmacodynamic (PK-PD) models of biofilm treatment could be used to guide formulation and administration strategies to better control bacterial lung infections. To this end, we developed a detailed pharmacodynamic mode...

  • Review
  • Open Access
8 Citations
9,076 Views
14 Pages

Non-Surgical Treatments of Trigeminal Neuralgia from the Perspective of a Pain Physician: A Narrative Review

  • Jin Young Lee,
  • Gil Ho Lee,
  • Seung Hyun Yi,
  • Woo Seog Sim,
  • Bae Wook Kim and
  • Hue Jung Park

Trigeminal neuralgia (TN) is a unilateral disorder characterized by electric shock-like pain, abrupt onset and termination, and limited to one or more branches of the trigeminal nerve. Various therapeutic modalities for TN have been introduced. We se...

  • Article
  • Open Access
7 Citations
2,398 Views
15 Pages

Zyxin (ZYX) is an actin-interacting protein with unknown biological functions in patients with osteosarcoma. This research sought to understand how ZYX affects the biological behavior of osteosarcoma cells and to identify the associated mechanism. Fi...

  • Review
  • Open Access
21 Citations
5,511 Views
22 Pages

Recent Advances in Microbiota-Associated Metabolites in Heart Failure

  • Sepiso K. Masenga,
  • Joreen P. Povia,
  • Propheria C. Lwiindi and
  • Annet Kirabo

Heart failure is a risk factor for adverse events such as sudden cardiac arrest, liver and kidney failure and death. The gut microbiota and its metabolites are directly linked to the pathogenesis of heart failure. As emerging studies have increased i...

  • Review
  • Open Access
4 Citations
3,428 Views
16 Pages

The Role of Novel Imaging and Biofluid Biomarkers in Traumatic Axonal Injury: An Updated Review

  • Marios Lampros,
  • Nikolaos Vlachos,
  • Parmenion P. Tsitsopoulos,
  • Anastasia K. Zikou,
  • Maria I. Argyropoulou,
  • Spyridon Voulgaris and
  • George A. Alexiou

Traumatic brain injury (TBI) is a leading cause of disability worldwide. Traumatic axonal injury (TAI) is a subtype of TBI resulting from high-impact forces that cause shearing and/or stretching of the axonal fibers in white matter tracts. It is pres...

  • Article
  • Open Access
3 Citations
3,211 Views
13 Pages

Renal Disorders with Oral Tyrosine Kinase Inhibitors in Metastatic Colorectal Cancer: An Analysis from the FDA Adverse Event Reporting System Database

  • Giulia Russo,
  • Maria Antonietta Barbieri,
  • Emanuela Elisa Sorbara,
  • Giuseppe Cicala,
  • Tindara Franchina,
  • Mariacarmela Santarpia,
  • Nicola Silvestris and
  • Edoardo Spina

Background: this study assessed the nephrotoxicity of regorafenib (REG) and encorafenib (ENC) in metastatic colorectal cancer (mCRC) through an analysis of reports from the US Food and Drug Administration’s Adverse Event Reporting System (FAERS...

  • Article
  • Open Access
12 Citations
4,348 Views
21 Pages

Isolation of Fucoxanthin from Sargassum oligocystum Montagne, 1845 Seaweed in Vietnam and Its Neuroprotective Activity

  • Dang Diem Hong,
  • Le Thi Thom,
  • Nguyen Cam Ha,
  • Ngo Thi Hoai Thu,
  • Hoang Thi Minh Hien,
  • Luu Thi Tam,
  • Nguyen Manh Dat,
  • Tran Mai Duc,
  • Nguyen Van Tru and
  • Nguyen Thi Minh Hang
  • + 1 author

Fucoxanthin extracted and purified from Vietnamese Sargassum oligocystum Montagne, 1845 exhibits various biological activities. In this study, the ability of fucoxanthin to inhibit acetylcholinesterase (AChE), the antioxidant activities, and the expr...

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Biomedicines - ISSN 2227-9059