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Biomolecules, Volume 11, Issue 5

May 2021 - 156 articles

Cover Story: Cardiac glycosides (CGs), well known for their cardiotonic properties, are commonly used in cardiac medicine. The biological activity of CGs is derived from the inhibition of Na+/ K+-ATPase, which is responsible for maintaining the resting potential and the balance of intracellular ions. Recently, novel applications of CGs have emerged. Since the ATPase is involved in a complex signalling cascade linked to apoptosis, CGs could be useful as anticancer agents. In addition, CGs are capable of inducing immunogenic cell death of cancer cells resulting in a strong induction of the anticancer immune response, in some cases leading to tumour eradication. In addition, CGs affect levels of various immune system markers and, thus, could be used to treat inflammation and some autoimmune diseases. Due to their immunogenic activity, CGs represent potentially very useful clinical, multifunctional compounds. View this paper
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Articles (156)

  • Article
  • Open Access
56 Citations
5,050 Views
16 Pages

Transcriptome and Metabolome Reveal Salt-Stress Responses of Leaf Tissues from Dendrobium officinale

  • Mingze Zhang,
  • Zhenming Yu,
  • Danqi Zeng,
  • Can Si,
  • Conghui Zhao,
  • Haobin Wang,
  • Chuanmao Li,
  • Chunmei He and
  • Jun Duan

Dendrobium officinale Kimura et Migo is a precious traditional Chinese medicine. Despite D. officinale displaying a good salt-tolerance level, the yield and growth of D. officinale were impaired drastically by the increasing soil secondary salinizati...

  • Article
  • Open Access
14 Citations
5,691 Views
25 Pages

Metabolomics-Guided Hypothesis Generation for Mechanisms of Intestinal Protection by Live Biotherapeutic Products

  • Jiayu Ye,
  • Lauren A. E. Erland,
  • Sandeep K. Gill,
  • Stephanie L. Bishop,
  • Andrea Verdugo-Meza,
  • Susan J. Murch and
  • Deanna L. Gibson

The use of live biotherapeutic products (LBPs), including single strains of beneficial probiotic bacteria or consortiums, is gaining traction as a viable option to treat inflammatory-mediated diseases like inflammatory bowel disease (IBD). However, L...

  • Review
  • Open Access
13 Citations
5,541 Views
22 Pages

A Bittersweet Computational Journey among Glycosaminoglycans

  • Giulia Paiardi,
  • Maria Milanesi,
  • Rebecca C. Wade,
  • Pasqualina D’Ursi and
  • Marco Rusnati

Glycosaminoglycans (GAGs) are linear polysaccharides. In proteoglycans (PGs), they are attached to a core protein. GAGs and PGs can be found as free molecules, associated with the extracellular matrix or expressed on the cell membrane. They play a ro...

  • Article
  • Open Access
8 Citations
2,582 Views
10 Pages

Objectives: The objective of this study was to determine and estimate the changing levels of matrix metalloproteinases 1 and 8 (MMP-1 and MMP-8) in GCF at consecutive stages of healing after root coverage procedure via modified coronally advanced tun...

  • Article
  • Open Access
10 Citations
5,720 Views
12 Pages

BIG3 and BIG5 Redundantly Mediate Vesicle Trafficking in Arabidopsis

  • Yiping Suo,
  • Fenhong Hu,
  • Haojie Zhu,
  • Di Li,
  • Rui Qi,
  • Jirong Huang and
  • Wenjuan Wu

Vesicle trafficking plays an important role in delivering a diverse range of cargoes between different membranous systems in eukaryotes. It is well documented that the brefeldin A (BFA)-inhibited guanine nucleotide exchange factor (GEF), named BIG, r...

  • Article
  • Open Access
15 Citations
3,028 Views
15 Pages

The Influence of rs1859168 Polymorphism on Serum Expression of HOTTIP and Its Target miR-615-3p in Egyptian Patients with Breast Cancer

  • Omayma O. Abdelaleem,
  • Olfat G. Shaker,
  • Marwa N. AbdelHafez,
  • Noha K. Abdelghaffar,
  • Hanaa M. Eid,
  • Mohamed Zaidan,
  • Abeer A. Khalefa,
  • Naglaa A. Ahmed,
  • Nada F. Hemeda and
  • Othman M. Zaki
  • + 2 authors

Background: Polymorphisms of long noncoding RNAs are lately documented as hazardous factors for the development of numerous tumors. Furthermore, the evaluation of noncoding RNAs has emerged as a novel detector of breast cancer patients. We aimed to g...

  • Article
  • Open Access
8 Citations
3,536 Views
13 Pages

Antigenotoxic Effects and Possible Mechanism of Red Yeast (Sporidiobolus pararoseus) on Aflatoxin B1-Induced Mutagenesis

  • Romteera Kittichaiworakul,
  • Sirinya Taya,
  • Arpamas Chariyakornkul,
  • Thanongsak Chaiyaso and
  • Rawiwan Wongpoomchai

Red yeast (Sporidiobolus pararoseus), obtained from glycerol waste in the biodiesel process, has been used as a mycotoxin sorbent in some agricultural products. This study focused on the antigenotoxic effects of red yeast on aflatoxin B1 (AFB1)-induc...

  • Review
  • Open Access
34 Citations
5,196 Views
34 Pages

Hard tissues (e.g., bone, enamel, dentin) in vertebrates perform various and different functions, from sustaining the body to haematopoiesis. Such complex and hierarchal tissue is actually a material composite whose static and dynamic properties are...

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Biomolecules - ISSN 2218-273X