Special Issue "Natural Products Metabolomics"

A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (31 January 2019)

Special Issue Editor

Guest Editor
Prof. Dr. Gustavo Zuñiga

Facultad de Química y Biologia. Universidad Santiago de Chile, Chile
Website | E-Mail
Interests: development of methodologies for in vitro plant culture to obtain natural products with biological activity

Special Issue Information

Dear Colleagues,

To identify and quantify metabolites in extracts of natural products is a challenging and urgent task. Metabolomics is a high-performance analytical technique globally-used to measure low molecular weight metabolites, allowing the simultaneous metabolic comparison of different biological samples. Although plants are recognized as prolific sources of bioactive substances, the traditional approach to the discovery of new molecules is time consuming and laborious. In this Special Issue of Metabolites, the use of NMR- or MS-based metabolomics is proposed as an efficient approach to find bioactive metabolites in plants and microorganisms. The coverage of this Special Issue includes, but is not limited to, the following topics:

  • Metabolomics analysis of plants under Climate change.
  • Metabolomics characterization of plant extracts.
  • Metabolomics of the interaction plant-endophytic organisms.
  • Metabolomics screening of biological activities. (antioxidant, antibacterial, antidiabetic, bioplaguicides, etc.)
  • Metabolomics of medicinal plants.
Prof. Dr. Gustavo Zuñiga
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • natural products
  • climate change
  • medicinal plants
  • bioactive metabolites

Published Papers (2 papers)

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Research

Open AccessArticle
Flavan-3-ols Content in Red Raspberry Leaves Increases under Blue Led-Light Irradiation
Metabolites 2019, 9(3), 56; https://doi.org/10.3390/metabo9030056
Received: 22 February 2019 / Revised: 18 March 2019 / Accepted: 20 March 2019 / Published: 21 March 2019
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Abstract
Berry fruits are well known to contain large amounts of polyphenol compounds. Among them, flavan-3-ol derivatives are a group of secondary metabolism compounds currently attracting a great deal of attention owing to their health benefits. Not only the fruits, but also the leaves [...] Read more.
Berry fruits are well known to contain large amounts of polyphenol compounds. Among them, flavan-3-ol derivatives are a group of secondary metabolism compounds currently attracting a great deal of attention owing to their health benefits. Not only the fruits, but also the leaves of raspberry plants, are highly esteemed for tea making around the world and are largely used for food. In this report, we discuss the results of our study on the effect of light and temperature on polyphenol accumulation in raspberry leaves. When raspberry was cultivated in a plant factory unit and light intensity, wavelength, and temperature were varied, the amount of total polyphenol increased under blue light. Quantitative determination of (+)-catechin, (–)-epicatechin, procyanidin B4, flavan-3-ol trimer, which are flavan-3-ol derivatives, was carried out using HPLC, whereby we confirmed their increase under blue light. Semi-quantitative RT-PCR showed correlation between chalcone synthase (CHS) gene expression and the amounts of the compounds measured in the leaves. Full article
(This article belongs to the Special Issue Natural Products Metabolomics)
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Open AccessArticle
HPLC-qTOF-MS/MS-Based Profiling of Flavan-3-ols and Dimeric Proanthocyanidins in Berries of Two Muscadine Grape Hybrids FLH 13-11 and FLH 17-66
Metabolites 2018, 8(4), 57; https://doi.org/10.3390/metabo8040057
Received: 22 August 2018 / Revised: 18 September 2018 / Accepted: 22 September 2018 / Published: 26 September 2018
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Abstract
FLH 13-11 FL and FLH 17-66 FL are two interspecific hybrid varieties of muscadine grape resulting from the cross of Vitis munsoniana (Simpson) ex Munson and V. rotundifolia. However, profiles of flavan-3-ols and proanthocyanidins in these two hybrids have not been characterized. [...] Read more.
FLH 13-11 FL and FLH 17-66 FL are two interspecific hybrid varieties of muscadine grape resulting from the cross of Vitis munsoniana (Simpson) ex Munson and V. rotundifolia. However, profiles of flavan-3-ols and proanthocyanidins in these two hybrids have not been characterized. Herein, we report the use of high-performance liquid chromatography-quadrupole, time-of-flight, tandem mass spectrometry (HPLC-qTOF-MS/MS) to characterize these two groups of metabolites in berries. Ripe berries collected from two consecutive cropping years were used to extract metabolites. Metabolites were ionized using the negative mode. Collision-induced dissociation was performed to fragmentize ions to obtain feature fragment profiles. Based on standards, MS features, and fragments resulted from MS/MS, four flavan-3-ol aglycones, 18 gallated or glycosylated conjugates, and eight dimeric procyanidins, were annotated from berry extracts. Of these 30 metabolites, six are new methylated flavan-3-ol gallates. Furthermore, comparative profiling analysis showed obvious effects of each cultivar on the composition these 30 metabolites, indicating that genotypes control biosynthesis. In addition, cropping seasons altered profiles of these metabolites, showing effects of growing years on metabolic composition. These data are informative to enhance the application of the two cultivars in grape and wine industries in the future. Full article
(This article belongs to the Special Issue Natural Products Metabolomics)
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