Next Article in Journal
Involvement of Spermidine in the Reduced Lifespan of Caenorhabditis elegans During Vitamin B12 Deficiency
Previous Article in Journal / Special Issue
Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort
Open AccessArticle

Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children

1
Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK
2
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK
3
Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, UK
4
UK National Institute for Health Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London SE5 8AF, UK
5
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden
6
University College London, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK
7
Department of Psychiatry, Faculty of Medicine, University of Geneva, CH–1205 Geneva, Switzerland
8
Icahn Mount Sinai School of Medicine, New York, NY 10029, USA
9
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
10
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
11
Bristol National Institute of Health Research Biomedical Research Centre, Bristol BS1 3NU, UK
12
Child and Adolescent Psychiatry Division, Department of Child and Adolescent Health, Geneva University Hospital, CH–1205 Geneva, Switzerland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Metabolites 2019, 9(9), 191; https://doi.org/10.3390/metabo9090191
Received: 15 July 2019 / Revised: 13 September 2019 / Accepted: 16 September 2019 / Published: 19 September 2019
(This article belongs to the Special Issue Metabolomics in Epidemiological Studies)
Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (n = 2929 participants), measuring 158 metabolic traits in non-fasting EDTA-plasma by nuclear magnetic resonance. We associated metabolic markers at 7 years (exposure) with risk for anorexia nervosa and binge-eating disorder (outcomes) at 14, 16, and 18 years using logistic regression adjusted for maternal education, child’s sex, age, body mass index, and calorie intake at 7 years. Elevated very low-density lipoproteins, triglycerides, apolipoprotein-B/A, and monounsaturated fatty acids ratio were associated with lower odds of anorexia nervosa at age 18, while elevated high-density lipoproteins, docosahexaenoic acid and polyunsaturated fatty acids ratio, and fatty acid unsaturation were associated with higher risk for anorexia nervosa at 18 years. Elevated linoleic acid and n-6 fatty acid ratios were associated with lower odds of binge-eating disorder at 16 years, while elevated saturated fatty acid ratio was associated with higher odds of binge-eating disorder. Most associations had large confidence intervals and showed, for anorexia nervosa, different directions across time points. Overall, our results show some evidence for a role of metabolic factors in eating disorders development in adolescence. View Full-Text
Keywords: metabolomics; nuclear magnetic resonance; EDTA-plasma; eating disorders; anorexia nervosa; binge-eating disorder; ALSPAC metabolomics; nuclear magnetic resonance; EDTA-plasma; eating disorders; anorexia nervosa; binge-eating disorder; ALSPAC
Show Figures

Figure 1

MDPI and ACS Style

Santos Ferreira, D.L.; Hübel, C.; Herle, M.; Abdulkadir, M.; Loos, R.J.F.; Bryant-Waugh, R.; Bulik, C.M.; De Stavola, B.L.; Lawlor, D.A.; Micali, N. Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children. Metabolites 2019, 9, 191.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop