Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children

Santos Ferreira, Diana L.; Hübel, Christopher; Herle, Moritz; Abdulkadir, Mohamed; Loos, Ruth J. F.; Bryant-Waugh, Rachel; Bulik, Cynthia M.; De Stavola, Bianca L.; Lawlor, Deborah A.; Micali, Nadia

doi:10.3390/metabo9090191

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Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children

Diana L. Santos Ferreira

^1,2,†

^3,4,5,†

⁶,

⁷,

⁸,

⁶,

^5,9,10,

⁶,

^1,2,11 and

^6,7,12,*

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK

Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, UK

⁴

UK National Institute for Health Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital, London SE5 8AF, UK

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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77 Stockholm, Sweden

⁶

University College London, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK

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Department of Psychiatry, Faculty of Medicine, University of Geneva, CH–1205 Geneva, Switzerland

⁸

Icahn Mount Sinai School of Medicine, New York, NY 10029, USA

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Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

¹⁰

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

¹¹

Bristol National Institute of Health Research Biomedical Research Centre, Bristol BS1 3NU, UK

¹²

Child and Adolescent Psychiatry Division, Department of Child and Adolescent Health, Geneva University Hospital, CH–1205 Geneva, Switzerland

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^†

These authors contributed equally to this work.

Metabolites 2019, 9(9), 191; https://doi.org/10.3390/metabo9090191

Received: 15 July 2019 / Revised: 13 September 2019 / Accepted: 16 September 2019 / Published: 19 September 2019

(This article belongs to the Special Issue Metabolomics in Epidemiological Studies)

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Abstract

Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (n = 2929 participants), measuring 158 metabolic traits in non-fasting EDTA-plasma by nuclear magnetic resonance. We associated metabolic markers at 7 years (exposure) with risk for anorexia nervosa and binge-eating disorder (outcomes) at 14, 16, and 18 years using logistic regression adjusted for maternal education, child’s sex, age, body mass index, and calorie intake at 7 years. Elevated very low-density lipoproteins, triglycerides, apolipoprotein-B/A, and monounsaturated fatty acids ratio were associated with lower odds of anorexia nervosa at age 18, while elevated high-density lipoproteins, docosahexaenoic acid and polyunsaturated fatty acids ratio, and fatty acid unsaturation were associated with higher risk for anorexia nervosa at 18 years. Elevated linoleic acid and n-6 fatty acid ratios were associated with lower odds of binge-eating disorder at 16 years, while elevated saturated fatty acid ratio was associated with higher odds of binge-eating disorder. Most associations had large confidence intervals and showed, for anorexia nervosa, different directions across time points. Overall, our results show some evidence for a role of metabolic factors in eating disorders development in adolescence. View Full-Text

Keywords: metabolomics; nuclear magnetic resonance; EDTA-plasma; eating disorders; anorexia nervosa; binge-eating disorder; ALSPAC

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Santos Ferreira, D.L.; Hübel, C.; Herle, M.; Abdulkadir, M.; Loos, R.J.F.; Bryant-Waugh, R.; Bulik, C.M.; De Stavola, B.L.; Lawlor, D.A.; Micali, N. Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children. Metabolites 2019, 9, 191. https://doi.org/10.3390/metabo9090191

AMA Style

Santos Ferreira DL, Hübel C, Herle M, Abdulkadir M, Loos RJF, Bryant-Waugh R, Bulik CM, De Stavola BL, Lawlor DA, Micali N. Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children. Metabolites. 2019; 9(9):191. https://doi.org/10.3390/metabo9090191

Chicago/Turabian Style

Santos Ferreira, Diana L., Christopher Hübel, Moritz Herle, Mohamed Abdulkadir, Ruth J.F. Loos, Rachel Bryant-Waugh, Cynthia M. Bulik, Bianca L. De Stavola, Deborah A. Lawlor, and Nadia Micali. 2019. "Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children" Metabolites 9, no. 9: 191. https://doi.org/10.3390/metabo9090191

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Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children

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