Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children
Abstract
:1. Introduction
2. Results
2.1. Descriptives
2.2. Metabolic Markers Associated with Anorexia Nervosa
2.3. Metabolic Markers Associated with Binge-Eating Disorder
2.4. Sensitivity Analyses
3. Discussion
4. Materials and Methods
4.1. Study Population
4.2. Eating Disorders Diagnoses and Covariates
4.3. EDTA-Plasma Metabolome Profiling
4.4. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
Lipoprotein Subclasses and Fatty Acids Details
References
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Eating Disorders Status by Assessment Age | n (%) | Female [n (%)] | Age (years) [mean (SD)] | Body Mass Index (kg/m2) [mean (SD)] | Average Total Calorie Intake (kcal) [mean (SD)] | Mother >12 Years in Education [n (%)] |
---|---|---|---|---|---|---|
Anorexia Nervosa (N = 2907) | ||||||
Diagnosis at 14 Years Old | ||||||
No Eating Disorder | 2224 (96) | 1057 (48)* | 7.5 (0.1) | 15.9 (1.8)* | 1726.3 (304.7)* | 1113 (50) |
Anorexia Nervosa | 87 (4) | 61 (70)* | 7.5 (0.1) | 14.6 (1.3)* | 1639.4 (255.8)* | 40 (46) |
Diagnosis at 16 Years Old | ||||||
No Eating Disorder | 1615 (97) | 729 (45)* | 7.5 (0.1) | 15.7 (1.6)* | 1729.4 (305.0)* | 853 (53) |
Anorexia Nervosa | 48 (3) | 37 (77)* | 7.4 (0.1) | 14.5 (0.9)* | 1565.8 (261.0)* | 25 (52) |
Diagosis at 18 Years Old | ||||||
No Eating Disorder | 1498 (98) | 697 (47)* | 7.4 (0.1) | 15.8 (1.7)* | 1728.9 (304.1) | 814 (54) |
Anorexia Nervosa | 26 (2) | 21 (81)* | 7.5 (0.1) | 14.6 (1.4)* | 1673.7 (248.9) | 15 (58) |
Cumulatively Across All Available Time Points (i.e., Eating Disorder Diagnosis at Age 14, 16, or 18 Years Old) | ||||||
No Eating Disorder | 1146 (90) | 655 (57) | 7.4 (0.1) | 16.1 (1.8)* | 1725.9 (301.6)* | 650 (57) |
Anorexia Nervosa | 127 (10) | 88 (69) | 7.5 (0.1) | 14.6 (1.2)* | 1636.8 (267.5)* | 63 (50) |
Binge-Eating Disorder (N = 2879) | ||||||
Diagnosis at 14 Years Old | ||||||
No Eating Disorder | 2240 (99) | 1070 (48) | 7.5 (0.1) | 15.9 (1.8) | 1723.3 (304.6) | 1122 (50) |
Binge-Eating Disorder | 14 (1) | 8 (57) | 7.4 (0.1) | 16.4 (1.1) | 1714.6 (422.2) | 4 (29) |
Diagnosis at 16 Years Old | ||||||
No Eating Disorder | 1620 (99) | 732 (45)* | 7.5 (0.1) | 15.7 (1.6)* | 1729.7 (304.5) | 857 (53) |
Binge-Eating Disorder | 21 (1) | 17 (81)* | 7.4 (0.2) | 16.7 (1.4)* | 1854.9 (263.8) | 10 (48) |
Diagnosis at 18 Years Old | ||||||
No Eating Disorder | 1498 (98) | 697 (47)* | 7.4 (0.1) | 15.8 (1.7) | 1728.9 (304.1) | 814 (54) |
Binge-Eating Disorder | 25 (2) | 20 (80)* | 7.4 (0.1) | 16.8 (1.9) | 1744.1 (329.6) | 15 (60) |
Cumulatively Across All Available Time Points (i.e., Eating Disorder Diagnosis at Age 14, 16, or 18 Years Old) | ||||||
No Eating Disorder | 1146 (97) | 655 (57) | 7.4 (0.1) | 16.1 (1.8) | 1725.9 (301.6) | 650 (57) |
Binge-Eating Disorder | 36 (3) | 27 (75) | 7.4 (0.1) | 16.6 (1.7) | 1808.7 (267.8) | 21 (58) |
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Santos Ferreira, D.L.; Hübel, C.; Herle, M.; Abdulkadir, M.; Loos, R.J.F.; Bryant-Waugh, R.; Bulik, C.M.; De Stavola, B.L.; Lawlor, D.A.; Micali, N. Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children. Metabolites 2019, 9, 191. https://doi.org/10.3390/metabo9090191
Santos Ferreira DL, Hübel C, Herle M, Abdulkadir M, Loos RJF, Bryant-Waugh R, Bulik CM, De Stavola BL, Lawlor DA, Micali N. Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children. Metabolites. 2019; 9(9):191. https://doi.org/10.3390/metabo9090191
Chicago/Turabian StyleSantos Ferreira, Diana L., Christopher Hübel, Moritz Herle, Mohamed Abdulkadir, Ruth J. F. Loos, Rachel Bryant-Waugh, Cynthia M. Bulik, Bianca L. De Stavola, Deborah A. Lawlor, and Nadia Micali. 2019. "Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children" Metabolites 9, no. 9: 191. https://doi.org/10.3390/metabo9090191