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Special Issue "Metabolomics to Probe Metabolism in Ageing and Age-related Neurodegenerative Diseases"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (30 September 2019).
Interests: Metabolite role and activity; metabolic phenotyping of human population; quantitative metabolomic and lipidomic approaches; sexual dimorphism in metabolism; stratified and personalized approach to medicine
Special Issues and Collections in MDPI journals
Today’s ageing society is confronted with an epidemic of metabolic diseases, among which the neurodegenerative diseases present an ever-growing medical and social burden. Neurodegeneration has only recently been identified as an energy metabolism disorder, whose progress is related to ageing and a chronic inflammation process (i.e. Alzheimer’s disease). Although ageing is a major risk factor for neurodegeneration, several external and internal environmental exposures, such as nutrition, oxidative stress and the microbiome, have been proven to influence the onset and progression of metabolic alterations and inflammation in neurodegenerative diseases.
Metabolomics has evolved as an integrated technology that includes biomarker discovery, pathway analysis and phenotypic control, and is thus emerging for the investigation and prospective modulation of metabolism in ageing and age-related metabolic diseases, such as neurodegenerative disorders. Due to their high-throughput and sensitivity to assess the phenotypic alterations at the molecular level, metabolomic approaches can be applied from model systems, from neuronal cell cultures and brain organoids to large-scale human population studies. They allow us to measure and monitor over time the systemic (i.e. circulating blood) and central nervous (i.e. CSF, brain tissue) effects of disease on energy production and storage as well as signaling pathways. These metabolic changes can further be examined as a function of sex, ageing, diet, physical activity, cognitive decline, inflammation process, etc., to gain additional insights into disease pathogenesis.
The topics to be covered in this Special Issue include the metabolomics-led discoveries and metabolomics-assisted mechanistic studies that enhance our understanding of ageing and age-related neurodegenerative diseases, from model systems to human population studies. Manuscripts that uncover the physiological roles of endogenous metabolites and their capacity to modulate the ageing (i.e NAD+ metabolism) and neurodegenerative disease phenotype are strongly encouraged.
Dr. Julijana Ivanišević
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Metabolic Drift in Ageing
- Ageing and Neurodegeneration as Metabolic Disorders
- Neurodegeneration and Inflammation
- Metabolomics-Led Discoveries in Ageing and Age-Related Neurodegenerative Diseases
- Metabolomics-Assisted Mechanistic Studies in Ageing and Age-Related Neurodegenerative Diseases
- Metabolomics Applied from Model Systems to Human Population Studies
- Quantitative Metabolomic Approaches
- Metabolite Activity to Modulate Metabolism