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The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD)
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Nicotinamide and NAFLD: Is There Nothing New Under the Sun?

1
Hepatology, Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland
2
Gastroenterology, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy
3
University Clinic of Visceral Surgery and Medicine, Inselspital Bern, 3008 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(9), 180; https://doi.org/10.3390/metabo9090180
Received: 8 August 2019 / Revised: 5 September 2019 / Accepted: 6 September 2019 / Published: 10 September 2019
(This article belongs to the Special Issue Metabolism and Metabolomics of Liver in Health and Disease)
Nicotinamide adenine dinucleotide (NAD) has a critical role in cellular metabolism and energy homeostasis. Its importance has been established early with the discovery of NAD’s therapeutic role for pellagra. This review addresses some of the recent findings on NAD physiopathology and their effects on nonalcoholic fatty liver disease (NAFLD) pathogenesis, which need to be considered in the search for a better therapeutic approach. Reduced NAD concentrations contribute to the dysmetabolic imbalance and consequently to the pathogenesis of NAFLD. In this perspective, the dietary supplementation or the pharmacological modulation of NAD levels appear to be an attractive strategy. These reviewed studies open the doors to growing interest in NAD metabolism for NAFLD diagnosis, prevention, and treatment. Future rigorous clinical studies in humans will be necessary to validate these preliminary but promising results. View Full-Text
Keywords: nicotinamide; NAFLD; steatosis nicotinamide; NAFLD; steatosis
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Guarino, M.; Dufour, J.-F. Nicotinamide and NAFLD: Is There Nothing New Under the Sun? Metabolites 2019, 9, 180.

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