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Open AccessArticle

Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.

1
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
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Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Pharmacognosy, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt
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Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Pharmacognosy, Faculty of Pharmacy, The Islamic University in Najaf, Najaf 54001, Iraq
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Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
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Garden for Medicinal Plants, Graduate School of Biomedical Sciences, Nagasaki University; Bunkyo-machi 1-14, Nagasaki 852-8521, Japan
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(11), 273; https://doi.org/10.3390/metabo9110273
Received: 13 October 2019 / Revised: 8 November 2019 / Accepted: 9 November 2019 / Published: 11 November 2019
A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis L., together with the known compounds indol-3-carboxylic acid (2), 1,5-dideoxy-3-C-methyl arabinitol (3), thymine (4), uracil (5), cyclo (L-pro-L-omet) (6) and macrolactin B (7). The structure of (1) was established to be cyclo (2α, 3-diaminopropoinc acid-L-Asn-3-β-hydroxy-5-methyl-tetradecanoic acid-L-Leu1-L-Asp-L-Val-L-Leu2-L-Leu3) by extensive spectroscopic techniques including 1H NMR, 13C NMR, 1H‒1H COSY, HMBC, HSQC, NOESY, and HRFABMS. The antimicrobial activities of compounds 1–7 were evaluated. Compounds 1–5, and 7 showed moderate antimicrobial activity while compound 6 exhibited a potent antimicrobial and antifungal activities. View Full-Text
Keywords: Corallina officinalis; Staphylococcus sp.; cyclic depsipeptide; antimicrobial assay Corallina officinalis; Staphylococcus sp.; cyclic depsipeptide; antimicrobial assay
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Abdelhameed, R.F.A.; Elhady, S.S.; Noor, A.O.; Almasri, D.M.; Bagalagel, A.A.; Maatooq, G.T.; Khedr, A.I.M.; Yamada, K. Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.. Metabolites 2019, 9, 273.

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