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Using Cerebral Metabolites to Guide Precision Medicine for Subarachnoid Hemorrhage: Lactate and Pyruvate

1
Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
2
Department of Neurologic Surgery, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
3
Department of Critical Care Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
*
Authors to whom correspondence should be addressed.
Metabolites 2019, 9(11), 245; https://doi.org/10.3390/metabo9110245
Received: 30 August 2019 / Revised: 9 October 2019 / Accepted: 22 October 2019 / Published: 23 October 2019
(This article belongs to the Special Issue Metabolomics in Precision Medicine)
Subarachnoid hemorrhage (SAH) is one of the deadliest types of strokes with high rates of morbidity and permanent injury. Fluctuations in the levels of cerebral metabolites following SAH can be indicators of brain injury severity. Specifically, the changes in the levels of key metabolites involved in cellular metabolism, lactate and pyruvate, can be used as a biomarker for patient prognosis and tailor treatment to an individual’s needs. Here, clinical research is reviewed on the usefulness of cerebral lactate and pyruvate measurements as a predictive tool for SAH outcomes and their potential to guide a precision medicine approach to treatment. View Full-Text
Keywords: subarachnoid hemorrhage; cerebral metabolism; lactate; pyruvate; lactate-pyruvate ratio; delayed cerebral ischemia; vasospasm; precision medicine subarachnoid hemorrhage; cerebral metabolism; lactate; pyruvate; lactate-pyruvate ratio; delayed cerebral ischemia; vasospasm; precision medicine
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MDPI and ACS Style

Zahra, K.; Gopal, N.; Freeman, W.D.; Turnbull, M.T. Using Cerebral Metabolites to Guide Precision Medicine for Subarachnoid Hemorrhage: Lactate and Pyruvate. Metabolites 2019, 9, 245.

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