Table of Contents
Metabolites, Volume 8, Issue 4 (December 2018)
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Cover Story (view full-size image) The human plasma metabolome contains vast amounts of information on the health status of the [...] Read more. The human plasma metabolome contains vast amounts of information on the health status of the individual. However, the factors that impact the variation in the human metabolome remain poorly characterized. In this paper, plasma metabolite profiles were associated with a range of clinical parameters in an extensively phenotyped cross-sectional population. The results revealed clear metabolic signatures related to, for example, liver and kidney function, as well as insulin resistance. Moreover, several metabolite factors were associated with the same phenotypic trait, indicating independent mechanisms. Since the results in this paper reflected findings from studies on severe clinical conditions, they may indicate early signs of disease in a largely healthy population. View this paper.