Table of Contents
Metabolites, Volume 9, Issue 1 (January 2019)
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Cover Story (view full-size image) Breast cancer patients undergoing combination chemotherapy with palbociclib and fulvestrant have [...] Read more. Breast cancer patients undergoing combination chemotherapy with palbociclib and fulvestrant have increased progression-free survival versus treatment with palbociclib alone, however the exact mechanisms for this increase in survival are not known. In this paper, we applied an innovative multi-omics approach to decipher metabolic pathways affected by single (versus combination) dosing of palbociclib and fulvestrant in estrogen receptor-positive breast cancer cells. Key metabolites and genes were correlated within metabolic pathways and shown to be involved in the drugs’ synergism. Notably, fulvestrant was shown to independently attenuate the pentose phosphate pathway and coenzyme production. This is the first study to merge omic datasets to investigate combined therapy on breast cancer cell metabolism. View this paper.