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Metabolites 2018, 8(4), 71; https://doi.org/10.3390/metabo8040071

Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease

1
Beaumont Health, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USA
2
Oakland University-William Beaumont School of Medicine, Rochester, MI 48309, USA
3
Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA
4
University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Received: 2 October 2018 / Revised: 23 October 2018 / Accepted: 26 October 2018 / Published: 31 October 2018
(This article belongs to the Special Issue Metabolomics in Neurodegenerative Disease)
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Abstract

For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the disease, when treatment is thought to be most effective. Currently, there are no robust biomarkers that aid in the early diagnosis of PD. Following previously reported work by our group, we accurately measured the concentrations of 18 bile acids in the serum of a prodromal mouse model of PD. We identified three bile acids at significantly different concentrations (p < 0.05) when mice representing a prodromal PD model were compared with controls. These include ω-murichoclic acid (MCAo), tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA). All were down-regulated in prodromal PD mice with TUDCA and UDCA at significantly lower levels (17-fold and 14-fold decrease, respectively). Using the concentration of three bile acids combined with logistic regression, we can discriminate between prodromal PD mice from control mice with high accuracy (AUC (95% CI) = 0.906 (0.777–1.000)) following cross validation. Our study highlights the need to investigate bile acids as potential biomarkers that predict PD and possibly reflect the progression of manifest PD. View Full-Text
Keywords: prodromal Parkinson’s disease; bile acids; mass spectrometry; biomarkers; α-synuclein aggregates prodromal Parkinson’s disease; bile acids; mass spectrometry; biomarkers; α-synuclein aggregates
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Graham, S.F.; Rey, N.L.; Ugur, Z.; Yilmaz, A.; Sherman, E.; Maddens, M.; Bahado-Singh, R.O.; Becker, K.; Schulz, E.; Meyerdirk, L.K.; Steiner, J.A.; Ma, J.; Brundin, P. Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease. Metabolites 2018, 8, 71.

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