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Metabolites 2018, 8(4), 92; https://doi.org/10.3390/metabo8040092

The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology

1,2,* and 1,2,3,4
1
Arthritis Program, University Health Network, Toronto, ON M5T 2S8, Canada
2
Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON M5T 2S8, Canada
3
Department of Surgery, University of Toronto, Toronto, ON M1C 1A4, Canada
4
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M1C 1A4, Canada
*
Author to whom correspondence should be addressed.
Received: 30 October 2018 / Revised: 7 December 2018 / Accepted: 10 December 2018 / Published: 13 December 2018
(This article belongs to the Special Issue Metabolomics of Complex Traits)
Full-Text   |   PDF [755 KB, uploaded 13 December 2018]   |  

Abstract

Osteoarthritis (OA) is a progressive, deteriorative disease of articular joints. Although traditionally viewed as a local pathology, biomarker exploration has shown that systemic changes can be observed. These include changes to cytokines, microRNAs, and more recently, metabolites. The metabolome is the set of metabolites within a biological sample and includes circulating amino acids, lipids, and sugar moieties. Recent studies suggest that metabolites in the synovial fluid and blood could be used as biomarkers for OA incidence, prognosis, and response to therapy. However, based on clinical, demographic, and anthropometric factors, the local synovial joint and circulating metabolomes may be patient specific, with select subsets of metabolites contributing to OA disease. This review explores the contribution of the local and systemic metabolite changes to OA, and their potential impact on OA symptoms and disease pathogenesis. View Full-Text
Keywords: metabolomics; precision medicine; osteoarthritis; local; systemic metabolomics; precision medicine; osteoarthritis; local; systemic
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Rockel, J.S.; Kapoor, M. The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology. Metabolites 2018, 8, 92.

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