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Metabolites, Volume 14, Issue 4

April 2024 - 69 articles

Cover Story: Little is known about lipid changes that occur with MASLD improvement. This study examined lipidome changes in 40 adolescent boys with hepatic steatosis ≥5%, randomized to a low-free sugar diet (LFSD) or usual diet for 8 weeks. Using LC-MS/MS, we observed decreased levels in triglycerides (TGs), diacylglycerols (DGs), cholesteryl esters (ChE), lysophosphatidylcholine (LPC), and phosphatidylcholine (PC) in the LFSD group. Network analysis showed significantly lower levels of palmitate-enriched TG species post-intervention. Targeted oxylipins analysis indicated changes in eicosanoids, with decreased 8-isoprostane and 14,15-DiHET and increased 8,9-DiHET. These lipids are linked to MASLD progression, suggesting potential improvement in lipid metabolism, DNL, insulin resistance, and lipotoxicity. View this paper
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Articles (69)

  • Article
  • Open Access
4 Citations
2,066 Views
12 Pages

Comparison of the Effect of Two Different Handling Conditions at Slaughter in Saliva Analytes in Pigs

  • María Botía,
  • Damián Escribano,
  • Alba Ortín-Bustillo,
  • María J. López-Martínez,
  • Pablo Fuentes,
  • Francisco J. Jiménez-Caparrós,
  • Juan L. Hernández-Gómez,
  • Antonio Avellaneda,
  • José J. Cerón and
  • Camila P. Rubio
  • + 4 authors

18 April 2024

In this report, different handling conditions at slaughterhouse were studied to assess changes in salivary biomarkers. For this purpose, finishing pigs were divided into two groups, one in which handling was improved to minimize stress (Group A, n =...

  • Article
  • Open Access
2 Citations
2,088 Views
15 Pages

Vitamin D and Ceramide Metabolomic Profile in Acute Myocardial Infarction

  • Melania Gaggini,
  • Federica Marchi,
  • Nataliya Pylypiv,
  • Alessandra Parlanti,
  • Simona Storti,
  • Umberto Paradossi,
  • Sergio Berti and
  • Cristina Vassalle

18 April 2024

Sphingolipids (SLs) influence several cellular pathways, while vitamin D exerts many extraskeletal effects in addition to its traditional biological functions, including the modulation of calcium homeostasis and bone health. Moreover, Vitamin D and S...

  • Review
  • Open Access
4 Citations
2,737 Views
18 Pages

Computational Applications: Beauvericin from a Mycotoxin into a Humanized Drug

  • Charbel Al Khoury,
  • Sima Tokajian,
  • Nabil Nemer,
  • Georges Nemer,
  • Kelven Rahy,
  • Sergio Thoumi,
  • Lynn Al Samra and
  • Aia Sinno

18 April 2024

Drug discovery was initially attributed to coincidence or experimental research. Historically, the traditional approaches were complex, lengthy, and expensive, entailing costly random screening of synthesized compounds or natural products coupled wit...

  • Article
  • Open Access
2,068 Views
14 Pages

18 April 2024

Heavy metal pollution poses significant environmental challenges, and understanding how plants and endophytic bacteria interact to mitigate these challenges is of utmost importance. In this study, we investigated the roles of endophytic bacteria, par...

  • Article
  • Open Access
2 Citations
1,962 Views
15 Pages

Discrimination of Lipogenic or Glucogenic Diet Effects in Early-Lactation Dairy Cows Using Plasma Metabolite Abundances and Ratios in Combination with Machine Learning

  • Xiaodan Wang,
  • Sanjeevan Jahagirdar,
  • Wouter Bakker,
  • Carolien Lute,
  • Bas Kemp,
  • Ariette van Knegsel and
  • Edoardo Saccenti

17 April 2024

During early lactation, dairy cows have a negative energy balance since their energy demands exceed their energy intake: in this study, we aimed to investigate the association between diet and plasma metabolomics profiles and how these relate to ener...

  • Hypothesis
  • Open Access
3 Citations
21,743 Views
24 Pages

Mitochondrial–Stem Cell Connection: Providing Additional Explanations for Understanding Cancer

  • Pierrick Martinez,
  • Ilyes Baghli,
  • Géraud Gourjon and
  • Thomas N. Seyfried

17 April 2024

The cancer paradigm is generally based on the somatic mutation model, asserting that cancer is a disease of genetic origin. The mitochondrial–stem cell connection (MSCC) proposes that tumorigenesis may result from an alteration of the mitochond...

  • Review
  • Open Access
15 Citations
18,381 Views
15 Pages

Iron Absorption: Molecular and Pathophysiological Aspects

  • Margherita Correnti,
  • Elena Gammella,
  • Gaetano Cairo and
  • Stefania Recalcati

17 April 2024

Iron is an essential nutrient for growth among all branches of life, but while iron is among the most common elements, bioavailable iron is a relatively scarce nutrient. Since iron is fundamental for several biological processes, iron deficiency can...

  • Article
  • Open Access
8 Citations
2,299 Views
19 Pages

Combined Metabolomics and Biochemical Analyses of Serum and Milk Revealed Parity-Related Metabolic Differences in Sanhe Dairy Cattle

  • Zixin Liu,
  • Aoyu Jiang,
  • Xiaokang Lv,
  • Dingkun Fan,
  • Qingqing Chen,
  • Yicheng Wu,
  • Chuanshe Zhou and
  • Zhiliang Tan

16 April 2024

The production performance of dairy cattle is closely related to their metabolic state. This study aims to provide a comprehensive understanding of the production performance and metabolic features of Sanhe dairy cattle across different parities, wit...

  • Article
  • Open Access
1 Citations
2,510 Views
16 Pages

A System Biology Approach Reveals New Targets for Human Thyroid Gland Toxicity in Embryos and Adult Individuals

  • Jeane Maria Oliveira,
  • Jamilli Zenzeluk,
  • Caroline Serrano-Nascimento,
  • Marco Aurelio Romano and
  • Renata Marino Romano

16 April 2024

Compounds of natural or synthetic origin present in personal care products, food additives, and packaging may interfere with hormonal regulation and are called endocrine-disrupting chemicals (EDCs). The thyroid gland is an important target of these c...

  • Article
  • Open Access
5 Citations
2,050 Views
22 Pages

15 April 2024

Marigold oleoresin is an oil-soluble natural colorant mainly extracted from marigold flowers. Xinjiang of China, India, and Zambia of Africa are the three main production areas of marigold flowers. Therefore, this study utilized ultra-performance liq...

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Metabolites - ISSN 2218-1989