2025 May - 131 articles
Osteoporosis is characterized by an imbalance between bone formation and resorption, leading to decreased bone mass and an increased fracture risk, mainly associated with aging. Current treatments include anti-resorptive and anabolic drugs. However,...
Cardiocrinum are perennial herbaceous plants of the Liliaceae family with high ornamental, nutritional, and medicinal value. However, critical knowledge gaps remain regarding the following: (1) the fine-scale habitat preferences of Cardiocrinum; (2)...
Sweet corn is highly susceptible to low temperatures, especially during seed germination, which severely affects plant growth and crop yield. This study used 100 sweet corn micro-core germplasms to evaluate two key germination traits under cold stres...
Smooth Brucella are the main pathogenic bacteria that threaten human health and food safety. The early stage of smooth Brucella and macrophage interaction is an important phase, and smooth Brucella species elicit a dramatic transcriptional response i...
Phytoplankton serve as crucial producers in marine ecosystems, and their community composition and populations’ dispersion directly or indirectly influence the productivity of marine waters via the trophic cascade effect within the food chain....
In avian behavioural and spatial ecology, issues related to population density, territoriality, and philopatry are especially important. These are often interrelated. The aim of this study was to analyse these behaviours in shrikes inhabiting an acac...
HLB is a severe and devastating disease affecting citrus plants, for which no cure is currently available. The pathogen CLas is an unculturable, phloem-limited α-proteobacterium associated with HLB. Phages, known for their ability to directly l...
Background: Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that shows significant efficacy in treating obesity. However, its associated side effects, including poor patient compliance and gastrointestinal inflammation, are concerni...
Myogenesis is a complex biological process regulated by multiple factors. This study systematically revealed the dynamic changes of gene expression and its regulatory network in C2C12 myoblasts during proliferation and differentiation stages by integ...
The Mediterranean trout (currently referred to as Salmo ghigii for Corsican and Italian-native populations) is listed as Endangered in the IUCN Red List, due to fragmented distribution and declining populations across its whole range, and is included...
The alterable light/dark cycle in a plant factory with artificial lighting eliminates the traditional concept of day and night in nature. Adjusting the light/dark cycle to closely align with the inherent circadian rhythm of plants can enhance biomass...
Glioblastoma (GBM) presents significant therapeutic challenges due to its invasive nature and resistance to standard chemotherapy, i.e., temozolomide (TMZ). This study aimed to identify gene signatures that predict poor TMZ response and high PD&minus...
Ion channels play ubiquitous roles in the maintenance of tumour cell homeostasis and hence are attractive targets in the molecular pathogenesis and progression of prostate cancer (PCa). This study aimed to investigate the roles of the potassium ion c...
With the rapid process of urbanization at a global scale, university campuses have been viewed as important urban green spaces for biodiversity conservation. However, little is known about the role of university campuses in protecting ecological spec...
Coenzyme Q10 is a natural antioxidant with anti-tumor and mitochondrial protective effects. However, its unstable physicochemical properties and large molecular weight result in low bioavailability. This study aimed to develop an effective technique...
This study systematically analyzed the expression and clinical significance of Hydroxysteroid 17-beta dehydrogenase type 10 (HSD17B10) in 33 cancers by integrating TCGA, GTEx, and other multi-omics databases. HSD17B10 was highly expressed in 14 cance...
Lung adenocarcinoma (LUAD) is one of the leading causes of death worldwide, and thus, more biomarker and therapeutic targets need to be explored. Herein, we aimed to explore new biomarkers of LUAD by integrating bioinformatics analysis with cell expe...
Mycobacterium indicus pranii (MIP), an atypical mycobacterium originally developed as an anti-leprosy vaccine, has emerged as a potent immunomodulator with diverse therapeutic applications. Despite its clinical significance, molecular mechanisms unde...
Human activities exert both beneficial and detrimental impacts on the ecosystem. In recent years, greenhouse gas emissions have significantly increased due to global climate change, causing profound alterations in ecosystem distribution and productiv...
The only vaccine against Haemonchus contortus is limited by short-lived antibody persistence and the need for frequent booster immunizations. This study leveraged the advantages of nano-adjuvants in enhancing antigen presentation and immune regulatio...
Anther is thought to release either bicellular or tricellular pollen when mature. Though a few species had been found to shed both bicellular and tricellular pollen, due to their low frequency, they had been overlooked as special cases of bicellular...
Acute kidney injury (AKI) is associated with increased in-hospital mortality, yet effective therapeutic agents remain limited. Coixol, a polyphenolic compound derived from Coix, possesses anti-inflammatory properties, but its role in AKI remains uncl...
An important area of interest for therapeutic development is the IL-1 superfamily, a critical group of immune regulators with profound implications in a variety of disorders. This study clarifies the evolutionary patterns of IL-1 family members by th...
The viability and host-seeking behavior of Strongyloides larvae are significantly influenced by soil conditions, emphasizing the critical role of environmental control in disease management. This is particularly relevant given the growing concerns ab...
The gastrointestinal (GI) tract is responsible for food digestion and host protection from harmful stimuli; however, its function as an endocrine organ is also well documented. Somatostatin (SST) was first discovered in the hypothalamus, but the GI t...
Although obesity and metabolic syndrome (comprising at least three of the following traits—abdominal obesity, elevated blood pressure, triglycerides and glucose/insulin resistance, and reduced high-density lipoprotein cholesterol in serum) are...
Since its inception in 1987, in vitro fertilization (IVF) has constituted a significant medical achievement in the field of fertility treatment, offering a viable solution to the challenge of infertility. The continuous evolution of assisted reproduc...
Microplastics (MPs) are emerging pollutants that are ubiquitous in aquatic ecosystems and can affect the stability of aquatic food webs. They are intentionally produced in a size of less than 5 mm for specific purposes or are the result of the fragme...
Background: The tissues of origin and molecular mechanisms underlying human complex diseases remain incompletely understood. Previous studies have leveraged transcriptomic data to interpret genome-wide association studies (GWASs) for identifying dise...
The aim of this study was to achieve the high secretion and expression of thymosin β4 derived from Pinctada fucata in Pichia pastoris, as well as to investigate its antibacterial properties and biological effects in promoting wound healing. The...
IAS imposes significant impacts on native ecosystems and economies. Current assessment methods for economic losses predominantly rely on habitat suitability estimation and database extrapolation, often lacking integration of causal inference and dyna...
Massive blooms of Ulva species, commonly known as green tides, pose serious ecological threats by disrupting coastal ecosystems and requiring costly removal efforts. This study presents a nature-based solution by seasonally valorizing Ulva ohnoi, a b...
As arsenopyrite is a typical arsenic-bearing sulfide ore, the biooxidation process of arsenopyrite is of great significance for the extraction of gold from arsenic-bearing gold ores and the generation of arsenic-bearing acid mine drainage. During the...
Advances in artificial intelligence (AI) and intelligent computing have significantly accelerated drug discovery by enabling accurate modeling of complex biomedical relationships. Among these efforts, drug repositioning—identifying novel therap...
Alzheimer’s disease (AD) remains a significant global health challenge with limited FDA-approved treatments, necessitating the search for novel preventive strategies. Antioxidants that are present in fruits and vegetables have garnered attentio...
Nanobodies, derived from naturally occurring heavy-chain antibodies in camelids (VHHs) and sharks (VNARs), are unique single-domain antibodies that have garnered significant attention in therapeutic, diagnostic, and biotechnological applications due...
Nitrogen fertilizers play a critical role in enhancing crop yields; however, excessive application has resulted in significant environmental challenges, including water contamination and increased greenhouse gas emissions. Therefore, improving nitrog...
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and a leading cause of cancer-related morbidity and mortality worldwide. Despite advancements in therapeutic strategies, the prognosis for NSCLC patients remains unfavorable...
Prostate cancer is among the most frequently diagnosed and deadly cancers among men in the Western world. It is typically classified as an immune “cold” tumor due to its sparse immune cell presence and limited immunogenic response. Recent...
Inflammation is a widespread physiological response that occurs when the body is stimulated by pathogens or endogenous signals [...]
This paper aims to investigate the dielectric properties of blood for tumor detection and staging. The application of complex thermodynamic models and the study of the trend over time of some thermodynamic functions have allowed us to highlight the g...
In mammals, the core molecular clock genes and the overall circadian system are established during early development; during this critical period of development, maternal metabolic condition plays a major role in programming temporal metabolic regula...
Trace mineral supplementation is critical for shrimp aquaculture sustainability, yet the bioavailability of conventional inorganic forms remains suboptimal. The study investigated the effects of inorganic (IM) and organic (OM) trace mineral premixes...
Breast cancer (BC) is among the most prevalent malignancies and remains the leading cause of cancer-related mortality in women worldwide. While prior studies have highlighted the associations between insulin resistance (IR) and both tumorigenesis and...
To address the growing consumer demands for improved fish meat quality, desirable morphological traits, and sustainable production practices, researchers have intensified efforts in the selective breeding and genetic improvement of carp (Cyprinus car...
(1) Background: Previous theoretical studies have provided arguments for the existence of a circular or hairpin RNA that could have served as a primitive informational and functional molecule at the origin of life. The present article consists of sea...
This study investigates ferroptosis in the context of peripheral artery disease (PAD), a vascular disease characterized by atherosclerosis of the lower extremities. Muscle atrophy and increased oxidative stress are hallmarks of PAD and correlate with...
Appropriate fertilization depth promotes the absorption and transport of nutrients, crop growth and yield. However, little is known about whether deep fertilization improves crude protein synthesis and how to regulate it. A two-year field experiment...
Pampus argenteus, a commercially significant marine species, faces genetic diversity challenges in selective breeding programs. This study implemented a comprehensive molecular strategy to evaluate genetic parameters in wild populations along China&r...
Bisphosphonates (BPs) are drugs used to cure metabolic diseases like osteoporosis and oncological conditions, such as multiple myeloma and bone metastases. The pharmacological activity of these compounds is mediated by their capacity to induce a syst...
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