Immune Microenvironment and Molecular Mechanism of Glioma
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 6505
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gliomas are the most common malignant primary brain tumors in adults. Conventionally, gliomas have been classified based on their histology by immunohistochemistry methods. However, in 2016, the World Health Organization (WHO) introduced molecular markers in its classification, enabling a more accurate description and prognosis for these tumors according to their molecular characteristics. Of note, the latest treatment for gliomas is surgical resection, combined with radiotherapy and chemotherapy. However, relapse is common, especially for glioblastomas (GBM; WHO grade IV), which are refractory to standard treatments because of their infiltration nature. Therefore, current therapies are only a temporary and limited solution. More recently, cancer immunotherapy, which has shown impressive results in the treatment of extracranial tumor types, is now being used for GBM treatment. However, disappointing outcomes of clinical studies involving immunotherapy treatment exposed the need for new approaches against GBM. Furthermore, GBM’s microenvironment is rich in immunosuppressive factors, such as cytokines like transforming growth factor-β and IL-10, which can polarize immune cells into a regulatory profile, thus contributing to tumor growth. This Special Issue will focus on original papers covering topics related to “Immune Microenvironment and Molecular Mechanism of Glioma” that present advances in those fields.
Dr. Carolina Cristina Jancic
Guest Editor
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Keywords
- gliomas
- tumor microenvironment
- immune response
- tumor evasion
- tumor resistance
- immunotherapy
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