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Biology, Volume 14, Issue 6

June 2025 - 153 articles

Cover Story: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with limited treatment options and poor survival rates. Patient-derived organoids (PDOs), which replicate tumor complexity in vitro, offer a powerful tool for modeling PDAC and testing therapies. In this study, we investigate the anti-tumor effects of an IL-1 receptor antagonist (IL-1RA) in both murine and human PDAC organoids. IL-1RA treatment reduces tumor-promoting elements like cancer-associated fibroblasts, enhancing immune cell access and response. Our findings highlight IL-1RA’s potential as a promising novel approach for PDAC and other cancers. View this paper
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Articles (153)

  • Article
  • Open Access
1 Citations
1,358 Views
17 Pages

Exploring the Bacterial Microbiome of High-Moisture Plant-Based Meat Substituted Soybean Flour with Mung Bean Protein and Duckweed Powder

  • Jutamat Klinsoda,
  • Theera Thurakit,
  • Kullanart Tongkhao,
  • Khemmapas Treesuwan,
  • Kanokwan Yodin and
  • Hataichanok Kantrong

19 June 2025

(1) Background: This study aimed to investigate the bacterial microbiomes in the ingredients and final PBM products during a storage period of 28 days at 2–4 °C for food safety and quality. (2) Methods: DNA from raw ingredients (i.e., defat...

  • Article
  • Open Access
1,318 Views
20 Pages

Functional and Genomic Evidence of L-Arginine-Dependent Bacterial Nitric Oxide Synthase Activity in Paenibacillus nitricinens sp. nov.

  • Diego Saavedra-Tralma,
  • Alexis Gaete,
  • Carolina Merino-Guzmán,
  • Maribel Parada-Ibáñez,
  • Francisco Nájera-de Ferrari and
  • Ignacio Jofré-Fernández

19 June 2025

Although nitric oxide (NO) production in bacteria has traditionally been associated with denitrification or stress responses in model or symbiotic organisms, functionally validated L-arginine-dependent nitric oxide synthase (bNOS) activity has not be...

  • Article
  • Open Access
5,902 Views
14 Pages

Potential Role of Probiotic Strain Lactiplantibacillus plantarum in Control of Histamine Metabolism

  • Gina Cavaliere,
  • Egidia Costanzi,
  • Beniamino Cenci-Goga,
  • Marco Misuraca and
  • Giovanna Traina

19 June 2025

Histamine intolerance is a condition that occurs when there is an imbalance between the accumulation and degradation of histamine within the body. Excess histamine is metabolized and then degraded by two enzymes, of which the most abundant is the ves...

  • Article
  • Open Access
1,023 Views
23 Pages

19 June 2025

This study investigates the mechanisms of zooplankton community assembly and their relationship to environmental factors in high-latitude arid regions. We conducted seasonal sampling at four reservoirs in the upper Tarim River Basin from 2023 to 2024...

  • Article
  • Open Access
902 Views
23 Pages

19 June 2025

Aletris spicata (Thunb.) Franch. (AS), a traditional edible and medicinal plant for treating asthma, was investigated for its therapeutic mechanisms. Liquid chromatography-high-resolution tandem mass spectrometry (LC-HRMS/MS) analysis identified 33 c...

  • Article
  • Open Access
2 Citations
4,830 Views
58 Pages

DNA Specimen Preservation Using DESS and DNA Extraction in Museum Collections

  • Eri Ogiso-Tanaka,
  • Daisuke Shimada,
  • Akito Ogawa,
  • Genki Ishiyama,
  • Ken-ichi Okumura,
  • Kentaro Hosaka,
  • Chikako Ishii,
  • Kyung-Ok Nam,
  • Masakazu Hoshino and
  • Shuhei Nomura
  • + 8 authors

19 June 2025

Recent advances in DNA research have increased the necessity for museums to preserve not only morphological specimens but also their DNA, leading us to maintain tissue samples linked to specimens at −80 °C. DNA analysis has become an essent...

  • Review
  • Open Access
1 Citations
2,080 Views
19 Pages

19 June 2025

Physical exercise induces epigenetic modifications that significantly influence the expression of a set of small non-coding RNAs known as miRNAs. These changes can enhance exercise performance and impact the neurological system, suggesting that under...

  • Article
  • Open Access
782 Views
15 Pages

Metabolic and Biochemical Responses of Juvenile Babylonia areolata to Hypoxia Stress

  • Baojun Tang,
  • Xiaoyao Ren,
  • Zhiguo Dong,
  • Hanfeng Zheng,
  • Yujia Liu and
  • Tao Wei

19 June 2025

As an important aquaculture species, the marine snail Babylonia areolata is frequently subjected to fluctuation in dissolved oxygen concentration during farming and transportation processes. In the present study, we investigated the metabolic rates,...

  • Article
  • Open Access
1,470 Views
13 Pages

Effect of Maternal Hyperglycemia on Fetal Pancreatic Islet Development

  • Carina Pereira Dias,
  • Michel Raony Teixeira Paiva de Moraes,
  • Fernanda Angela Correia Barrence,
  • Camila Stephanie Balbino da Silva,
  • Basilio Smuckzec,
  • Fernanda Ortis and
  • Telma Maria Tenório Zorn

19 June 2025

Hyperglycemia during fetal development disturbs extracellular matrix (ECM) synthesis and deposition patterns, which disrupts organogenesis and adult organ function. Although the ECM cooperates in pancreas development, little is known about the effect...

  • Article
  • Open Access
1 Citations
1,125 Views
18 Pages

Isolation and Bioactive Characterization of Berberis kaschgarica Rupr-Derived Exosome-Like Nanovesicles: Exploring Therapeutic Potential in Atherosclerosis Pathogenesis

  • Dilihuma Dilimulati,
  • Nuerbiye Nueraihemaiti,
  • Alhar Baishan,
  • Sendaer Hailati,
  • Alifeiye Aikebaier,
  • Yipaerguli Paerhati and
  • Wenting Zhou

19 June 2025

Berberis kaschgarica Rupr.-derived exosome-like nanovesicles (BELNs), a type of plant-derived extracellular vesicle, consist of proteins, lipids, and nucleic acids. In this research, we employed differential centrifugation and ultracentrifugation tec...

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Biology - ISSN 2079-7737