2024 December - 77 articles
β-parvalbumin (β-PV) is the primary fish allergen responsible for most allergic reactions in individuals sensitive to fish. To ensure food safety, a sandwich-based magnetic immunoassay was developed using maleimide-functionalized magnetic b...
Peroxynitrite (ONOO−) plays an important role in many physiological and pathological processes. Excessive ONOO− in cells leads to oxidative stress and inflammation. However, precise monitoring of ONOO− levels in specific organelles...
Vibrio parahaemolyticus (V. parahaemolyticus) is a significant concern, as it can cause severe infections and hemolytic trauma. Given its prevalence in seawater and coastal seafood, it poses a substantial risk as a foodborne pathogen. Biosensor-based...
Staphylococcus aureus (S. aureus) represents one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. It is a part of the infamous ESKAPE group, which is highly connected with increased rates of healthcare-asso...
NO2 is a toxic gas that can damage the lungs with prolonged exposure and contribute to health conditions, such as asthma in children. Detecting NO2 is therefore crucial for maintaining a healthy environment. Carbon nanotubes (CNTs) are promising mate...
Vascular endothelial growth factor (VEGF) is a critical angiogenesis biomarker associated with various pathological conditions, including cancer. This study leverages pre-biotinylated FcγRI interactions with IgG1-type monoclonal antibodies to d...
Antibiotics, celebrated as some of the most significant pharmaceutical breakthroughs in medical history, are capable of eliminating or inhibiting bacterial growth, offering a primary defense against a wide array of bacterial infections. However, the...
In recent years, in vitro skin sensitization assays have been recommended as animal-free alternatives for the safety assessment of cosmetics and topical drugs, and these methods have been adopted in OECD test guidelines. However, existing assays rema...
Monitoring respiration rate (RR) is crucial in various healthcare settings, particularly during demanding (physical) activities where respiratory dynamics are critical indicators of health status. This study aimed to evaluate the accuracy of photople...
The evolution of high-performance electrode materials has significantly impacted the development of real-time monitoring biosensors, emphasizing the need for compatibility with biomaterials and robust electrochemical properties. This work focuses on...
To face the increasing requirement for grains as the global population continues to grow, improving both crop yield and quality has become essential. Plant health directly impacts crop quality and yield, making the development of plant health-monitor...
This work discusses the state of the art and challenges in using wearable sensors for the monitoring of neurological patients. The authors share their experience from their participation in numerous projects, ranging from drug trials to rehabilitatio...
Nanopipettes, as a class of solid-state nanopores, have evolved into universal tools in biomedicine for the detection of biomarkers and different biological analytes. Nanopipette-based methods combine high sensitivity, selectivity, single-molecule re...
In this study, 3,4-diaminobenzoic acid (DABA) was introduced into the porphyrin metal–organic framework (PCN-224) for the first time to prepare a ratiometric fluorescent probe (PCN-224-DABA) to quantitatively detect ferric iron (Fe(III)) and se...
Lung cancer is the most common type of cancer diagnosed worldwide and is also among the most fatal. Early detection, before symptoms become evident, is fundamental for patients’ survival. Therefore, several lung cancer biomarkers have been prop...
Metal nanoclusters (NCs) are promising alternatives to organic dyes and quantum dots. These NCs exhibit unique physical and chemical properties, such as fluorescence, chirality, magnetism and catalysis, which contribute to significant advancements in...
Enzyme-based portable amperometric biosensors are precise and low-cost medical devices used for rapid cancer biomarker screening. Sarcosine (Sar) is an ideal biomarker for prostate cancer (PCa). Because human serum and urine contain complex interferi...
Sarcopenia has been a serious concern in the context of an increasingly aging global population. Existing detection methods for sarcopenia are severely constrained by cumbersome devices, the necessity for specialized personnel, and controlled experim...
There is an ongoing search for a reliable and continuous method of noninvasive blood pressure (BP) tracking. In this study, we investigate the feasibility of utilizing seismocardiogram (SCG) signals, i.e., chest motion caused by cardiac activity, for...
Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension but is often illicitly added to energy drinks and chocolates. This study introduces a lateral flow strip test using aptamers specific to sildenafil for detecting its...
Two-dimensional materials with a nanostructure have been introduced as promising candidates for SERS platforms for sensing application. However, the dynamic control and tuning of SERS remains a long-standing problem. Here, we demonstrated active tuni...
The Phi29 DNA polymerase is renowned for its processivity in synthesizing single-stranded DNA amplicons by rolling around a circularized DNA template. However, DNA synthesis rolling circle amplification (RCA) is significantly hindered by the secondar...
The demand for non-invasive, real-time health monitoring has driven advancements in wearable sensors for tracking biomarkers in sweat. Ammonium ions (NH4+) in sweat serve as indicators of metabolic function, muscle fatigue, and kidney health. Althoug...
Detecting and tracking the preclinical stages of Alzheimer’s disease (AD) is now of particular interest due to the aging of the world’s population. AD is the most common cause of dementia, affecting the daily lives of those afflicted. App...
(1) Background: In drug discovery and pharmaceutical quality control, a challenge is to assess protein extracts used for allergy therapy and in vivo diagnosis, such as prick tests. Indeed, there are significant differences between the features of mar...
The prevention and early warning of foot ulcers are crucial in diabetic care; however, early microvascular lesions are difficult to detect and often diagnosed at later stages, posing serious health risks. Infrared thermal imaging, as a rapid and non-...
Bright biocompatible fluorescent imaging dyes with red to near-infrared (NIR) emissions are ideal candidates for fluorescence microscopy applications. Pyrene–benzothiazolium hemicyanine dyes are a new class of lysosome-specific probes reported...
Microfluidic devices have revolutionized biosensing by enabling precise manipulation of minute fluid volumes across diverse applications. This review investigates the incorporation of machine learning (ML) into the design, fabrication, and applicatio...
Preeclampsia is a pregnancy-specific hypertensive syndrome recognized as the leading cause of maternal and fetal morbidity worldwide. Early diagnosis is crucial for mitigating its adverse effects, and recent investigations have identified endoglin as...
Lateral flow assays are widely used in point-of-care diagnostics but face challenges in sensitivity and accuracy when detecting low analyte concentrations, such as thyroid-stimulating hormone biomarkers. This study aims to enhance assay performance b...
Diagnostics often require specialized equipment and trained personnel in laboratory settings, creating a growing need for point-of-care tests (POCTs). Among the genetic testing methods available, Loop-mediated Isothermal Amplification (LAMP) offers a...
Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor with high prevalence in southern China. Aberrant DNA methylation, as a hallmark of cancer, is extensively present in NPC, the detection of which facilitates early diagnosis and prognosti...
A novel approach to developing lateral flow assays (LFAs) for the detection of CYFRA 21-1 (cytokeratin 19 fragment, a molecular biomarker for epithelial-origin cancers) is proposed. Magnetic bioconjugates (MBCs) were employed in combination with adva...
Simultaneous monitoring of antimicrobial responses to bacterial metabolic activity and biofilm formation is critical for efficient screening of new anti-biofilm drugs. A microbial fuel cell-based biosensor using Pseudomonas aeruginosa as an electrici...
Accurate methods for assessing food freshness through colorimetric pH response play a critical role in determining food spoilage and ensuring food quality standards. This study introduces a novel unlabeled DNA sequence, poly-dA20, designed to exploit...
Accurate and selective monitoring of thiamine levels in multivitamin supplements is essential for preventing deficiencies and ensuring product quality. To achieve this, a Förster resonance energy transfer (FRET) system using carbon dots (CDs) as...
Escherichia coli (E. coli) detection suffers from slow analysis time and high costs, along with the need for specificity. While state-of-the-art electrochemical biosensors are cost-efficient and easy to implement, their sensitivity and analysis time...
Terahertz (THz) spectroscopy, an advanced label-free sensing method, offers significant potential for biomolecular detection and quantitative analysis in biological samples. Although broadband fingerprint enhancement compensates for limitations in de...
Surface plasmon resonance (SPR) biosensors have experienced rapid development in recent years and have been widely applied in various fields. Angular-interrogation SPR biosensors play an important role in the field of biological detection due to thei...
In order to identify carcinoembryonic antigen (CEA) in serum samples, an innovative smartphone-based, label-free electrochemical immunosensor was created without the need for additional labels or markers. This technology presents a viable method for...
In this study, we detected the expression levels of miR-21 in 38 clinical urine samples, obtained from 10 patients with PCa (with each sample obtained at three time points: before surgery, 1 month after surgery, and 3 months after surgery), 3 patient...
Gatifloxacin (GAT), an antibiotic belonging to the fluoroquinolone (FQ) class, is a toxicant that may contaminate food products. In this study, a method of ultrasensitive immunochromatographic detection of GAT was developed for the first time. An ind...
Nanomaterials have attracted significant attention as signal reporters for immunoassays. They can directly generate detectable signals or release a large number of signaling elements for readout. Among various nanolabels, nanomaterials composed of mu...
Receptor-based biosensors often suffer from slow analyte diffusion, leading to extended assay times. Moreover, existing methods to enhance diffusion can be complex and costly. In response to this challenge, we presented a rapid and cost-effective tec...
In the biosensor field, the accurate detection of contagious disease has become one of the most important research topics in the post-pandemic period. However, conventional contagious viral biosensors normally require chemical modifications to introd...
Ankle-foot orthoses (AFOs) have been commonly prescribed for stroke survivors with foot drop, but their impact on the contractions of paretic tibialis anterior (TA) and medial gastrocnemius (MG) has remained inconclusive. This study thus investigated...
Over the past few years, nanoplasmonic biosensors have gained widespread interest for early diagnosis of diseases thanks to their simple design, low detection limit down to the biomolecule level, high sensitivity to even small molecules, cost-effecti...
The COVID-19 pandemic has prompted the need for the development of new biosensors for SARS-CoV-2 detection. Particularly, systems with qualities such as sensitivity, fast detection, appropriate to large-scale analysis, and applicable in situ, avoidin...
Surface-enhanced Raman scattering (SERS) is a powerful optical sensing platform that amplifies the target signals by Raman scattering. Despite SERS enabling a meager detection limit, even at the single-molecule level, SERS also tends to equally enhan...
Smartphones equipped with highly integrated sensors are increasingly being recognized as powerful tools for rapid on-site testing. Here, we propose a low-cost, portable, and highly multiplexed smartphone-based spectrometer capable of collecting three...
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