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Biosensors
Special Issues
Advances in Plasmonic Biosensing Technology
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Advances in Plasmonic Biosensing Technology

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 5435

Special Issue Editor

Dr. Taerin Chung

E-Mail Website
Guest Editor
Department of Electrical and Computer Engineering, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
Interests: nanoplasmonics; photonics; nanostructures and biophotonic materials; label-free; Surface-Enhanced Raman Scattering (SERS) nanoprobes; optical sensing

Special Issue Information

Dear Colleagues,

This Special Issue aims to present cutting-edge methods and instrumentation related to the novel research area of plasmonic-based biosensing technologies and related nanosystems, as well as their applications in biology and medicine. The demand for attainable and affordable healthcare for infectious and chronic diseases has significantly increased in this century. Traditional approaches are expanding to include point-of-care (POC) diagnostics, bedside testing, and community-based approaches responding to these challenges. Advanced plasmonic-based diagnostics features real-time, non-invasive, and label-free characteristics, which is unique. These innovative solutions have been accelerated by recent advances in mobile technologies, nanofabrication technology, imaging systems, and microfluidic technologies.

Both review articles and research articles related to plasmonic-based biosensing technologies are welcome.

Dr. Taerin Chung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • properties of metallic nanostructures
  • plasmonics-based sensors
  • surface plasmon resonance (SPR) sensing systems
  • surface-enhanced Raman scattering (SERS) and biomedical applications
  • nano-optics
  • nanophotonics
  • fabrications of nanostructured substrates
  • spectroscopies related to plasmonics
  • single-molecule spectroscopy
  • single-cell analysis metallomics detection using plasmonics
  • metal nanoparticle contrast agents for medical diagnostics
  • metal-enhanced fluorescence MEF
  • quantum plasmonic sensing and imaging

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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22 pages, 4507 KiB  
Article
Exploring the Interaction of Biotinylated FcGamma RI and IgG1 Monoclonal Antibodies on Streptavidin-Coated Plasmonic Sensor Chips for Label-Free VEGF Detection
by Soodeh Salimi Khaligh, Fahd Khalid-Salako, Hasan Kurt and Meral Yüce
Biosensors 2024, 14(12), 634; https://doi.org/10.3390/bios14120634 - 20 Dec 2024
Viewed by 916
Abstract
Vascular endothelial growth factor (VEGF) is a critical angiogenesis biomarker associated with various pathological conditions, including cancer. This study leverages pre-biotinylated FcγRI interactions with IgG1-type monoclonal antibodies to develop a sensitive VEGF detection method. Utilizing surface plasmon resonance (SPR) technology, we characterized the [...] Read more.
Vascular endothelial growth factor (VEGF) is a critical angiogenesis biomarker associated with various pathological conditions, including cancer. This study leverages pre-biotinylated FcγRI interactions with IgG1-type monoclonal antibodies to develop a sensitive VEGF detection method. Utilizing surface plasmon resonance (SPR) technology, we characterized the binding dynamics of immobilized biotinylated FcγRI to an IgG1-type antibody, Bevacizumab (AVT), through kinetic studies and investigated suitable conditions for sensor surface regeneration. Subsequently, we characterized the binding of FcγRI-captured AVT to VEGF, calculating kinetic constants and binding affinity. A calibration curve was established to analyze the VEGF quantification capacity and accuracy of the biosensor, computing the limits of blank, detection, and quantification at a 95% confidence interval. Additionally, the specificity of the biosensor for VEGF over other protein analytes was assessed. This innovative biomimetic approach enabled FcγRI-mediated site-specific AVT capture, establishing a stable and reusable platform for detecting and accurately quantifying VEGF. The results indicate the effectiveness of the plasmonic sensor platform for VEGF detection, making it suitable for research applications and, potentially, clinical diagnostics. Utilizing FcγRI-IgG1 antibody binding, this study highlights the industrial and clinical value of advanced biosensing technologies, offering insights to enhance therapeutic monitoring and improve outcomes in anti-VEGF therapies. Full article
(This article belongs to the Special Issue Advances in Plasmonic Biosensing Technology)
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8 pages, 1877 KiB  
Communication
Single-Nanoparticle Electrochemical Collision for Monitoring Self-Assembly of Thiol Molecules on Au Nanoparticles
by Yiyan Bai
Biosensors 2024, 14(8), 393; https://doi.org/10.3390/bios14080393 - 15 Aug 2024
Cited by 1 | Viewed by 1337
Abstract
A precise understanding of the self-assembly kinetics of small molecules on nanoparticles (NPs) can give greater control over the size and architecture of the functionalized NPs. Herein, a single-nanoparticle electrochemical collision (SNEC)-based method was developed to monitor the self-assembly processes of 6-mercapto-1-hexanol (6-MCH) [...] Read more.
A precise understanding of the self-assembly kinetics of small molecules on nanoparticles (NPs) can give greater control over the size and architecture of the functionalized NPs. Herein, a single-nanoparticle electrochemical collision (SNEC)-based method was developed to monitor the self-assembly processes of 6-mercapto-1-hexanol (6-MCH) and 1-hexanethiol (MCH) on Au NPs at the single-particle level, and to investigate the self-assembly kinetics exactly. Results showed that the self-assembly processes of both consisted of rapid adsorption and slow recombination. However, the adsorption rate of MCH was significantly lower than that of 6-MCH due to the poorer polarity. Also noteworthy is that the rapid adsorption of 6-MCH on Au NPs conformed to the Langmuir model of diffusion control. Hence, the proposed SNEC-based method could serve as a complementary method to research the self-assembly mechanism of functionalized NPs. Full article
(This article belongs to the Special Issue Advances in Plasmonic Biosensing Technology)
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12 pages, 2575 KiB  
Communication
Thiram Determination in Milk Samples by Surface Plasmon Resonance Based on Molecularly Imprinted Polymers and Sulphur-Doped Titanium Dioxide
by Sezen Harmankaya, Hacı Ahmet Deveci, Ahmet Harmankaya, Fatma Hazan Gül, Necip Atar and Mehmet Lütfi Yola
Biosensors 2024, 14(7), 329; https://doi.org/10.3390/bios14070329 - 3 Jul 2024
Cited by 10 | Viewed by 1498
Abstract
In this work, a new surface plasmon resonance (SPR) sensor based on sulphur-doped titanium dioxide (S-TiO2) nanostructures and molecularly imprinted polymer (MIP) was presented for thiram (THI) determination in milk samples. Firstly, the S-TiO2 nanomaterial with a high product yield [...] Read more.
In this work, a new surface plasmon resonance (SPR) sensor based on sulphur-doped titanium dioxide (S-TiO2) nanostructures and molecularly imprinted polymer (MIP) was presented for thiram (THI) determination in milk samples. Firstly, the S-TiO2 nanomaterial with a high product yield was prepared by using a facile sol-gel hydrolysis technique with a high product yield. After that, UV polymerization was carried out for the preparation of the THI-imprinted SPR chip based on S-TiO2 using a mixture including ethylene glycol dimethacrylate (EGDMA) as the cross-linker, N,N′-azobisisobutyronitrile (AIBN) as the initiator, and methacryloylamidoglutamicacid (MAGA) as the monomer. The reliability of the sensor preparation procedure has been successfully proven by characterization studies of the prepared nanomaterials and SPR chip surfaces through spectroscopic, microscopic, and electrochemical methods. As a result, the prepared SPR sensor showed linearity in the range of 1.0 × 10−9–1.0 × 10−7 M with a detection limit (LOD) of 3.3 × 10−10 M in the real samples, and a sensor technique for THI determination with high sensitivity, repeatability, and selectivity can be included in the literature. Full article
(This article belongs to the Special Issue Advances in Plasmonic Biosensing Technology)
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Review

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20 pages, 1292 KiB  
Review
A Review Study on Molecularly Imprinting Surface Plasmon Resonance Sensors for Food Analysis
by Bahar Bankoğlu Yola, Neslihan Özdemir and Mehmet Lütfi Yola
Biosensors 2024, 14(12), 571; https://doi.org/10.3390/bios14120571 - 25 Nov 2024
Cited by 2 | Viewed by 1237
Abstract
Surface plasmon resonance (SPR) sensors have emerged as a powerful tool in biosensing applications due to their ability to provide sensitive and real-time detection of chemical and biological analytes. This review focuses on the development and application of molecularly imprinted polymer (MIP)-based SPR [...] Read more.
Surface plasmon resonance (SPR) sensors have emerged as a powerful tool in biosensing applications due to their ability to provide sensitive and real-time detection of chemical and biological analytes. This review focuses on the development and application of molecularly imprinted polymer (MIP)-based SPR sensors for food analysis. By combining the high selectivity of molecular imprinting techniques with the sensitivity of SPR, these sensors offer significant advantages in detecting food contaminants and other target molecules. The article covers the basic principles of SPR, the role of MIPs in sensor specificity, recent advancements in this sensor development, and food applications. Furthermore, the potential for these sensors to contribute to food safety and quality control was explored, showcasing their adaptability to complex food matrices. The review concluded the future directions and challenges of SPR-MIP sensors in food analysis, emphasizing their promise in achieving high-throughput, cost-effective, and portable sensing solutions. Full article
(This article belongs to the Special Issue Advances in Plasmonic Biosensing Technology)
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